Details of the Target
General Information of Target
Target ID | LDTP04536 | |||||
---|---|---|---|---|---|---|
Target Name | Ephrin-A5 (EFNA5) | |||||
Gene Name | EFNA5 | |||||
Gene ID | 1946 | |||||
Synonyms |
EPLG7; LERK7; Ephrin-A5; AL-1; EPH-related receptor tyrosine kinase ligand 7; LERK-7 |
|||||
3D Structure | ||||||
Sequence |
MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV
FCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQL FTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDK VENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL |
|||||
Target Bioclass |
Other
|
|||||
Family |
Ephrin family
|
|||||
Subcellular location |
Cell membrane
|
|||||
Function |
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
|
|||||
Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
---|---|---|---|---|---|
OPA-S-S-alkyne Probe Info |
![]() |
K166(0.58); K180(6.21) | LDD3494 | [1] | |
DBIA Probe Info |
![]() |
C164(1.97) | LDD3360 | [2] | |
IA-alkyne Probe Info |
![]() |
N.A. | LDD0165 | [3] | |
NAIA_5 Probe Info |
![]() |
N.A. | LDD2223 | [4] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0214 | AC1 | HEK-293T | C164(1.08) | LDD1507 | [5] |
LDCM0215 | AC10 | HEK-293T | C164(1.11); C53(0.89) | LDD1508 | [5] |
LDCM0226 | AC11 | HEK-293T | C53(1.46) | LDD1509 | [5] |
LDCM0237 | AC12 | HEK-293T | C53(0.95) | LDD1510 | [5] |
LDCM0259 | AC14 | HEK-293T | C164(1.25) | LDD1512 | [5] |
LDCM0270 | AC15 | HEK-293T | C164(1.00) | LDD1513 | [5] |
LDCM0276 | AC17 | HEK-293T | C164(1.15) | LDD1515 | [5] |
LDCM0277 | AC18 | HEK-293T | C164(1.13); C53(1.16) | LDD1516 | [5] |
LDCM0278 | AC19 | HEK-293T | C53(1.15) | LDD1517 | [5] |
LDCM0279 | AC2 | HEK-293T | C164(1.03); C53(1.03) | LDD1518 | [5] |
LDCM0280 | AC20 | HEK-293T | C53(1.28) | LDD1519 | [5] |
LDCM0282 | AC22 | HEK-293T | C164(1.03) | LDD1521 | [5] |
LDCM0283 | AC23 | HEK-293T | C164(1.01) | LDD1522 | [5] |
LDCM0285 | AC25 | HEK-293T | C164(1.07) | LDD1524 | [5] |
LDCM0286 | AC26 | HEK-293T | C164(1.11); C53(0.90) | LDD1525 | [5] |
LDCM0287 | AC27 | HEK-293T | C53(1.14) | LDD1526 | [5] |
LDCM0288 | AC28 | HEK-293T | C53(1.05) | LDD1527 | [5] |
LDCM0290 | AC3 | HEK-293T | C53(1.08) | LDD1529 | [5] |
LDCM0291 | AC30 | HEK-293T | C164(1.13) | LDD1530 | [5] |
LDCM0292 | AC31 | HEK-293T | C164(0.99) | LDD1531 | [5] |
LDCM0294 | AC33 | HEK-293T | C164(1.07) | LDD1533 | [5] |
LDCM0295 | AC34 | HEK-293T | C164(1.05); C53(1.15) | LDD1534 | [5] |
LDCM0296 | AC35 | HEK-293T | C53(1.15) | LDD1535 | [5] |
LDCM0297 | AC36 | HEK-293T | C53(1.28) | LDD1536 | [5] |
LDCM0299 | AC38 | HEK-293T | C164(1.29) | LDD1538 | [5] |
LDCM0300 | AC39 | HEK-293T | C164(1.02) | LDD1539 | [5] |
LDCM0301 | AC4 | HEK-293T | C53(0.99) | LDD1540 | [5] |
LDCM0303 | AC41 | HEK-293T | C164(1.10) | LDD1542 | [5] |
LDCM0304 | AC42 | HEK-293T | C164(1.08); C53(1.08) | LDD1543 | [5] |
LDCM0305 | AC43 | HEK-293T | C53(1.16) | LDD1544 | [5] |
LDCM0306 | AC44 | HEK-293T | C53(1.24) | LDD1545 | [5] |
LDCM0308 | AC46 | HEK-293T | C164(1.23) | LDD1547 | [5] |
LDCM0309 | AC47 | HEK-293T | C164(1.06) | LDD1548 | [5] |
LDCM0311 | AC49 | HEK-293T | C164(1.08) | LDD1550 | [5] |
LDCM0313 | AC50 | HEK-293T | C164(0.97); C53(0.87) | LDD1552 | [5] |
LDCM0314 | AC51 | HEK-293T | C53(0.93) | LDD1553 | [5] |
LDCM0315 | AC52 | HEK-293T | C53(1.24) | LDD1554 | [5] |
LDCM0317 | AC54 | HEK-293T | C164(1.13) | LDD1556 | [5] |
LDCM0318 | AC55 | HEK-293T | C164(1.07) | LDD1557 | [5] |
LDCM0320 | AC57 | HEK-293T | C164(1.13) | LDD1559 | [5] |
LDCM0321 | AC58 | HEK-293T | C164(1.01); C53(1.27) | LDD1560 | [5] |
LDCM0322 | AC59 | HEK-293T | C53(1.26) | LDD1561 | [5] |
LDCM0323 | AC6 | HEK-293T | C164(1.26) | LDD1562 | [5] |
LDCM0324 | AC60 | HEK-293T | C53(1.08) | LDD1563 | [5] |
LDCM0326 | AC62 | HEK-293T | C164(1.12) | LDD1565 | [5] |
LDCM0327 | AC63 | HEK-293T | C164(1.03) | LDD1566 | [5] |
LDCM0334 | AC7 | HEK-293T | C164(1.03) | LDD1568 | [5] |
LDCM0356 | AKOS034007680 | HEK-293T | C164(1.15) | LDD1570 | [5] |
LDCM0368 | CL10 | HEK-293T | C164(1.40) | LDD1572 | [5] |
LDCM0369 | CL100 | HEK-293T | C164(1.11); C53(0.87) | LDD1573 | [5] |
LDCM0371 | CL102 | HEK-293T | C164(1.18); C53(0.96) | LDD1575 | [5] |
LDCM0372 | CL103 | HEK-293T | C164(1.11); C53(0.94) | LDD1576 | [5] |
LDCM0373 | CL104 | HEK-293T | C164(0.99); C53(0.84) | LDD1577 | [5] |
LDCM0375 | CL106 | HEK-293T | C164(1.06); C53(0.96) | LDD1579 | [5] |
LDCM0376 | CL107 | HEK-293T | C164(0.96); C53(1.21) | LDD1580 | [5] |
LDCM0377 | CL108 | HEK-293T | C164(1.03); C53(0.94) | LDD1581 | [5] |
LDCM0379 | CL11 | HEK-293T | C164(1.09) | LDD1583 | [5] |
LDCM0380 | CL110 | HEK-293T | C164(1.09); C53(0.98) | LDD1584 | [5] |
LDCM0381 | CL111 | HEK-293T | C164(1.09); C53(0.75) | LDD1585 | [5] |
LDCM0382 | CL112 | HEK-293T | C164(1.14); C53(0.76) | LDD1586 | [5] |
LDCM0384 | CL114 | HEK-293T | C164(1.22); C53(1.35) | LDD1588 | [5] |
LDCM0385 | CL115 | HEK-293T | C164(1.10); C53(1.03) | LDD1589 | [5] |
LDCM0386 | CL116 | HEK-293T | C164(1.05); C53(1.32) | LDD1590 | [5] |
LDCM0388 | CL118 | HEK-293T | C164(1.00); C53(1.03) | LDD1592 | [5] |
LDCM0389 | CL119 | HEK-293T | C164(1.13); C53(0.98) | LDD1593 | [5] |
LDCM0391 | CL120 | HEK-293T | C164(0.99); C53(0.84) | LDD1595 | [5] |
LDCM0393 | CL122 | HEK-293T | C164(0.99); C53(1.04) | LDD1597 | [5] |
LDCM0394 | CL123 | HEK-293T | C164(1.05); C53(0.84) | LDD1598 | [5] |
LDCM0395 | CL124 | HEK-293T | C164(1.06); C53(1.07) | LDD1599 | [5] |
LDCM0397 | CL126 | HEK-293T | C164(1.27); C53(1.13) | LDD1601 | [5] |
LDCM0398 | CL127 | HEK-293T | C164(1.12); C53(0.94) | LDD1602 | [5] |
LDCM0399 | CL128 | HEK-293T | C164(1.10); C53(1.08) | LDD1603 | [5] |
LDCM0401 | CL14 | HEK-293T | C164(1.14); C53(1.44) | LDD1605 | [5] |
LDCM0402 | CL15 | HEK-293T | C164(1.05); C53(0.75) | LDD1606 | [5] |
LDCM0403 | CL16 | HEK-293T | C164(1.06); C53(1.08) | LDD1607 | [5] |
LDCM0404 | CL17 | HEK-293T | C164(1.01) | LDD1608 | [5] |
LDCM0405 | CL18 | HEK-293T | C164(1.04); C53(1.10) | LDD1609 | [5] |
LDCM0406 | CL19 | HEK-293T | C53(1.12) | LDD1610 | [5] |
LDCM0407 | CL2 | HEK-293T | C164(1.10); C53(1.17) | LDD1611 | [5] |
LDCM0408 | CL20 | HEK-293T | C53(1.17) | LDD1612 | [5] |
LDCM0410 | CL22 | HEK-293T | C164(1.09) | LDD1614 | [5] |
LDCM0411 | CL23 | HEK-293T | C164(1.07) | LDD1615 | [5] |
LDCM0414 | CL26 | HEK-293T | C164(0.94); C53(1.15) | LDD1618 | [5] |
LDCM0415 | CL27 | HEK-293T | C164(0.98); C53(0.80) | LDD1619 | [5] |
LDCM0416 | CL28 | HEK-293T | C164(0.96); C53(1.13) | LDD1620 | [5] |
LDCM0417 | CL29 | HEK-293T | C164(1.01) | LDD1621 | [5] |
LDCM0418 | CL3 | HEK-293T | C164(0.94); C53(1.01) | LDD1622 | [5] |
LDCM0419 | CL30 | HEK-293T | C164(1.05); C53(1.36) | LDD1623 | [5] |
LDCM0420 | CL31 | HEK-293T | C53(1.20) | LDD1624 | [5] |
LDCM0421 | CL32 | HEK-293T | C53(1.04) | LDD1625 | [5] |
LDCM0423 | CL34 | HEK-293T | C164(1.13) | LDD1627 | [5] |
LDCM0424 | CL35 | HEK-293T | C164(1.09) | LDD1628 | [5] |
LDCM0428 | CL39 | HEK-293T | C164(1.06); C53(0.93) | LDD1632 | [5] |
LDCM0429 | CL4 | HEK-293T | C164(1.01); C53(0.92) | LDD1633 | [5] |
LDCM0430 | CL40 | HEK-293T | C164(1.01); C53(0.91) | LDD1634 | [5] |
LDCM0431 | CL41 | HEK-293T | C164(0.99) | LDD1635 | [5] |
LDCM0432 | CL42 | HEK-293T | C164(1.00); C53(1.40) | LDD1636 | [5] |
LDCM0433 | CL43 | HEK-293T | C53(1.11) | LDD1637 | [5] |
LDCM0434 | CL44 | HEK-293T | C53(1.06) | LDD1638 | [5] |
LDCM0436 | CL46 | HEK-293T | C164(1.17) | LDD1640 | [5] |
LDCM0437 | CL47 | HEK-293T | C164(1.08) | LDD1641 | [5] |
LDCM0440 | CL5 | HEK-293T | C164(0.95) | LDD1644 | [5] |
LDCM0441 | CL50 | HEK-293T | C164(0.97); C53(1.14) | LDD1645 | [5] |
LDCM0443 | CL52 | HEK-293T | C164(0.95); C53(0.94) | LDD1646 | [5] |
LDCM0444 | CL53 | HEK-293T | C164(1.08) | LDD1647 | [5] |
LDCM0445 | CL54 | HEK-293T | C164(0.97); C53(1.12) | LDD1648 | [5] |
LDCM0446 | CL55 | HEK-293T | C53(1.33) | LDD1649 | [5] |
LDCM0447 | CL56 | HEK-293T | C53(1.03) | LDD1650 | [5] |
LDCM0449 | CL58 | HEK-293T | C164(1.29) | LDD1652 | [5] |
LDCM0450 | CL59 | HEK-293T | C164(1.03) | LDD1653 | [5] |
LDCM0451 | CL6 | HEK-293T | C164(1.06); C53(1.35) | LDD1654 | [5] |
LDCM0454 | CL62 | HEK-293T | C164(1.04); C53(0.98) | LDD1657 | [5] |
LDCM0455 | CL63 | HEK-293T | C164(1.04); C53(0.92) | LDD1658 | [5] |
LDCM0456 | CL64 | HEK-293T | C164(0.89); C53(0.84) | LDD1659 | [5] |
LDCM0457 | CL65 | HEK-293T | C164(1.01) | LDD1660 | [5] |
LDCM0458 | CL66 | HEK-293T | C164(1.05); C53(1.21) | LDD1661 | [5] |
LDCM0459 | CL67 | HEK-293T | C53(1.17) | LDD1662 | [5] |
LDCM0460 | CL68 | HEK-293T | C53(1.16) | LDD1663 | [5] |
LDCM0462 | CL7 | HEK-293T | C53(1.41) | LDD1665 | [5] |
LDCM0463 | CL70 | HEK-293T | C164(1.08) | LDD1666 | [5] |
LDCM0464 | CL71 | HEK-293T | C164(1.03) | LDD1667 | [5] |
LDCM0467 | CL74 | HEK-293T | C164(1.10); C53(1.16) | LDD1670 | [5] |
LDCM0469 | CL76 | HEK-293T | C164(1.00); C53(0.95) | LDD1672 | [5] |
LDCM0470 | CL77 | HEK-293T | C164(1.10) | LDD1673 | [5] |
LDCM0471 | CL78 | HEK-293T | C164(1.00); C53(0.94) | LDD1674 | [5] |
LDCM0472 | CL79 | HEK-293T | C53(1.20) | LDD1675 | [5] |
LDCM0473 | CL8 | HEK-293T | C53(1.23) | LDD1676 | [5] |
LDCM0474 | CL80 | HEK-293T | C53(1.27) | LDD1677 | [5] |
LDCM0476 | CL82 | HEK-293T | C164(1.25) | LDD1679 | [5] |
LDCM0477 | CL83 | HEK-293T | C164(1.13) | LDD1680 | [5] |
LDCM0480 | CL86 | HEK-293T | C164(1.04); C53(1.23) | LDD1683 | [5] |
LDCM0481 | CL87 | HEK-293T | C164(1.06); C53(0.91) | LDD1684 | [5] |
LDCM0482 | CL88 | HEK-293T | C164(0.98); C53(1.02) | LDD1685 | [5] |
LDCM0483 | CL89 | HEK-293T | C164(1.14) | LDD1686 | [5] |
LDCM0485 | CL90 | HEK-293T | C164(1.15); C53(0.87) | LDD1688 | [5] |
LDCM0486 | CL91 | HEK-293T | C53(1.32) | LDD1689 | [5] |
LDCM0487 | CL92 | HEK-293T | C53(1.27) | LDD1690 | [5] |
LDCM0489 | CL94 | HEK-293T | C164(1.27) | LDD1692 | [5] |
LDCM0490 | CL95 | HEK-293T | C164(1.21) | LDD1693 | [5] |
LDCM0493 | CL98 | HEK-293T | C164(1.07); C53(1.03) | LDD1696 | [5] |
LDCM0494 | CL99 | HEK-293T | C164(1.13); C53(0.87) | LDD1697 | [5] |
LDCM0495 | E2913 | HEK-293T | C164(1.10); C53(1.11) | LDD1698 | [5] |
LDCM0468 | Fragment33 | HEK-293T | C164(1.07); C53(0.88) | LDD1671 | [5] |
LDCM0427 | Fragment51 | HEK-293T | C164(1.08); C53(1.08) | LDD1631 | [5] |
LDCM0022 | KB02 | ICC106 | C164(1.44) | LDD2380 | [2] |
LDCM0023 | KB03 | ICC10 | C164(1.72) | LDD2796 | [2] |
LDCM0024 | KB05 | NCI-H3122 | C164(1.97) | LDD3360 | [2] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
Transporter and channel
GPCR
Cytokine and receptor
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
Atypical chemokine receptor 2 (ACKR2) | G-protein coupled receptor 1 family | O00590 |
Other
References