Details of the Target

General Information of Target

Target ID LDTP04478
Target Name Adenylate cyclase type 7 (ADCY7)
Gene Name ADCY7
Gene ID 113
Synonyms
KIAA0037; Adenylate cyclase type 7; EC 4.6.1.1; ATP pyrophosphate-lyase 7; Adenylate cyclase type VII; Adenylyl cyclase 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN
Target Bioclass
Enzyme
Family
Adenylyl cyclase class-4/guanylyl cyclase family
Subcellular location
Membrane
Function
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex. Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells.
Uniprot ID
P51828
Ensemble ID
ENST00000254235.7
HGNC ID
HGNC:238
ChEMBL ID
CHEMBL2097167

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C320(1.56)  LDD2117  [1]
DBIA
 Probe Info  		C1068(0.88)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C320(1.56)  LDD2117  [1]
 LDCM0215  AC10 PaTu 8988t C821(1.63)  LDD1094  [2]
 LDCM0226  AC11 PaTu 8988t C821(1.40)  LDD1105  [2]
 LDCM0237  AC12 PaTu 8988t C821(1.09)  LDD1116  [2]
 LDCM0259  AC14 PaTu 8988t C821(1.39)  LDD1138  [2]
 LDCM0270  AC15 PaTu 8988t C821(1.45)  LDD1149  [2]
 LDCM0285  AC25 PaTu 8988t C821(1.00)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C821(1.44)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C821(1.37)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C821(1.50)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C821(1.16)  LDD1168  [2]
 LDCM0291  AC30 PaTu 8988t C821(1.18)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C821(1.38)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C821(1.15)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C821(1.46)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C821(1.05)  LDD1174  [2]
 LDCM0320  AC57 PaTu 8988t C821(0.98)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C821(1.16)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C821(0.94)  LDD1201  [2]
 LDCM0323  AC6 PaTu 8988t C821(1.11)  LDD1202  [2]
 LDCM0324  AC60 PaTu 8988t C821(1.02)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C821(1.00)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C821(1.07)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C821(1.00)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C821(1.09)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C821(1.09)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C821(1.10)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C821(1.03)  LDD1210  [2]
 LDCM0334  AC7 PaTu 8988t C821(0.91)  LDD1213  [2]
 LDCM0345  AC8 PaTu 8988t C821(1.02)  LDD1224  [2]
 LDCM0349  AC83 PaTu 8988t C821(1.22)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C821(1.24)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C821(0.91)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C821(1.27)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C821(0.93)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C821(1.00)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C821(1.08)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C821(0.80)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C821(0.89)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C821(1.51)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C821(0.86)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C821(0.92)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C821(0.90)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C821(0.81)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C821(0.72)  LDD1243  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C821(1.51)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C821(1.14)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C821(1.08)  LDD1154  [2]
 LDCM0020  ARS-1620 HCC44 C1068(0.88)  LDD0078  [2]
 LDCM0367  CL1 PaTu 8988t C821(1.30)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C821(2.23)  LDD1247  [2]
 LDCM0370  CL101 PaTu 8988t C821(0.99)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C821(1.09)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C821(1.35)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C821(1.11)  LDD1252  [2]
 LDCM0379  CL11 PaTu 8988t C821(1.20)  LDD1258  [2]
 LDCM0382  CL112 PaTu 8988t C821(1.12)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C821(1.07)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C821(1.24)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C821(1.47)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C821(1.32)  LDD1265  [2]
 LDCM0390  CL12 PaTu 8988t C821(1.47)  LDD1269  [2]
 LDCM0396  CL125 PaTu 8988t C821(0.92)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C821(1.01)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C821(0.98)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C821(0.88)  LDD1278  [2]
 LDCM0400  CL13 PaTu 8988t C821(1.72)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C821(1.95)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C821(1.49)  LDD1281  [2]
 LDCM0407  CL2 PaTu 8988t C821(1.41)  LDD1286  [2]
 LDCM0418  CL3 PaTu 8988t C821(1.08)  LDD1297  [2]
 LDCM0429  CL4 PaTu 8988t C821(1.43)  LDD1308  [2]
 LDCM0436  CL46 PaTu 8988t C821(1.08)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C821(1.12)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C821(1.20)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C821(1.08)  LDD1318  [2]
 LDCM0440  CL5 PaTu 8988t C821(1.67)  LDD1319  [2]
 LDCM0441  CL50 PaTu 8988t C821(1.39)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C821(1.13)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C821(1.10)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C821(1.42)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C821(1.94)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C821(1.16)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C821(1.34)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C821(1.21)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C821(1.13)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C821(1.12)  LDD1329  [2]
 LDCM0451  CL6 PaTu 8988t C821(1.63)  LDD1330  [2]
 LDCM0452  CL60 PaTu 8988t C821(1.37)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C821(1.01)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C821(1.35)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C821(1.31)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C821(1.30)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C821(1.37)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C821(1.67)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C821(1.20)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C821(1.16)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C821(1.83)  LDD1340  [2]
 LDCM0462  CL7 PaTu 8988t C821(1.54)  LDD1341  [2]
 LDCM0463  CL70 PaTu 8988t C821(1.16)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C821(1.18)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C821(1.45)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C821(1.39)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C821(1.21)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C821(1.06)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C821(1.35)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C821(1.48)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C821(1.72)  LDD1351  [2]
 LDCM0473  CL8 PaTu 8988t C821(2.20)  LDD1352  [2]
 LDCM0474  CL80 PaTu 8988t C821(1.18)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C821(1.59)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C821(1.63)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C821(1.65)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C821(1.33)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C821(1.49)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C821(1.55)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C821(1.35)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C821(1.46)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C821(1.52)  LDD1362  [2]
 LDCM0484  CL9 PaTu 8988t C821(1.44)  LDD1363  [2]
 LDCM0485  CL90 PaTu 8988t C821(1.74)  LDD1364  [2]
 LDCM0468  Fragment33 PaTu 8988t C821(1.66)  LDD1347  [2]
 LDCM0022  KB02 T cell C895(13.52); C904(0.00)  LDD1703  [4]
 LDCM0023  KB03 Jurkat C895(38.75)  LDD0209  [5]
 LDCM0024  KB05 HMCB C1068(2.06)  LDD3312  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C320(1.59)  LDD2127  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Colforsin Small molecular drug DB02587

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840