Details of the Target

General Information of Target

Target ID LDTP04178
Target Name Transcription factor SOX-2 (SOX2)
Gene Name SOX2
Gene ID 6657
Synonyms
Transcription factor SOX-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMA
QENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLM
KKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGY
PQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSM
GSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQS
GPVPGTAINGTLPLSHM
Target Type
Literature-reported
Target Bioclass
Transcription factor
Subcellular location
Nucleus speckle
Function
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.
TTD ID
T00724
Uniprot ID
P48431
DrugMap ID
TTCNOT6
Ensemble ID
ENST00000325404.3
HGNC ID
HGNC:11195

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C265(1.45)  LDD3333  [1]
IA-alkyne
 Probe Info  		C265(20.00)  LDD0372  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
VSF
 Probe Info  		N.A.  LDD0007  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C265(20.00)  LDD0372  [2]
 LDCM0237  AC12 HEK-293T C265(0.98)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C265(1.18)  LDD1512  [5]
 LDCM0280  AC20 HEK-293T C265(0.93)  LDD1519  [5]
 LDCM0282  AC22 HEK-293T C265(1.09)  LDD1521  [5]
 LDCM0288  AC28 HEK-293T C265(0.94)  LDD1527  [5]
 LDCM0291  AC30 HEK-293T C265(1.03)  LDD1530  [5]
 LDCM0297  AC36 HEK-293T C265(0.97)  LDD1536  [5]
 LDCM0299  AC38 HEK-293T C265(0.98)  LDD1538  [5]
 LDCM0301  AC4 HEK-293T C265(1.01)  LDD1540  [5]
 LDCM0306  AC44 HEK-293T C265(0.95)  LDD1545  [5]
 LDCM0308  AC46 HEK-293T C265(1.11)  LDD1547  [5]
 LDCM0315  AC52 HEK-293T C265(0.98)  LDD1554  [5]
 LDCM0317  AC54 HEK-293T C265(1.20)  LDD1556  [5]
 LDCM0323  AC6 HEK-293T C265(1.10)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C265(1.09)  LDD1563  [5]
 LDCM0326  AC62 HEK-293T C265(1.13)  LDD1565  [5]
 LDCM0368  CL10 HEK-293T C265(1.37)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C265(0.98)  LDD1573  [5]
 LDCM0373  CL104 HEK-293T C265(1.06)  LDD1577  [5]
 LDCM0377  CL108 HEK-293T C265(1.04)  LDD1581  [5]
 LDCM0382  CL112 HEK-293T C265(1.04)  LDD1586  [5]
 LDCM0386  CL116 HEK-293T C265(1.17)  LDD1590  [5]
 LDCM0391  CL120 HEK-293T C265(1.15)  LDD1595  [5]
 LDCM0395  CL124 HEK-293T C265(1.04)  LDD1599  [5]
 LDCM0399  CL128 HEK-293T C265(1.09)  LDD1603  [5]
 LDCM0403  CL16 HEK-293T C265(1.19)  LDD1607  [5]
 LDCM0408  CL20 HEK-293T C265(1.17)  LDD1612  [5]
 LDCM0410  CL22 HEK-293T C265(1.31)  LDD1614  [5]
 LDCM0416  CL28 HEK-293T C265(1.14)  LDD1620  [5]
 LDCM0421  CL32 HEK-293T C265(1.13)  LDD1625  [5]
 LDCM0423  CL34 HEK-293T C265(1.16)  LDD1627  [5]
 LDCM0429  CL4 HEK-293T C265(1.18)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C265(1.14)  LDD1634  [5]
 LDCM0434  CL44 HEK-293T C265(0.97)  LDD1638  [5]
 LDCM0436  CL46 HEK-293T C265(1.32)  LDD1640  [5]
 LDCM0443  CL52 HEK-293T C265(1.20)  LDD1646  [5]
 LDCM0447  CL56 HEK-293T C265(1.17)  LDD1650  [5]
 LDCM0449  CL58 HEK-293T C265(1.31)  LDD1652  [5]
 LDCM0456  CL64 HEK-293T C265(1.15)  LDD1659  [5]
 LDCM0460  CL68 HEK-293T C265(1.05)  LDD1663  [5]
 LDCM0463  CL70 HEK-293T C265(1.08)  LDD1666  [5]
 LDCM0469  CL76 HEK-293T C265(1.13)  LDD1672  [5]
 LDCM0473  CL8 HEK-293T C265(1.13)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C265(0.95)  LDD1677  [5]
 LDCM0476  CL82 HEK-293T C265(1.15)  LDD1679  [5]
 LDCM0482  CL88 HEK-293T C265(1.00)  LDD1685  [5]
 LDCM0487  CL92 HEK-293T C265(1.04)  LDD1690  [5]
 LDCM0489  CL94 HEK-293T C265(1.23)  LDD1692  [5]
 LDCM0022  KB02 HEK-293T C265(0.95)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C265(1.01)  LDD1497  [5]
 LDCM0024  KB05 MOLM-13 C265(1.45)  LDD3333  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Protein kinase C iota type (PRKCI) AGC Ser/Thr protein kinase family P41743
Serine/threonine-protein kinase VRK1 (VRK1) CK1 Ser/Thr protein kinase family Q99986
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 5, transcription factor 1 (POU5F1) POU transcription factor family Q01860
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Methyl-CpG-binding domain protein 3 (MBD3) . O95983

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402