Details of the Target

General Information of Target

Target ID LDTP04069
Target Name ATP-binding cassette sub-family G member 1 (ABCG1)
Gene Name ABCG1
Gene ID 9619
Synonyms
ABC8; WHT1; ATP-binding cassette sub-family G member 1; EC 7.6.2.-; ATP-binding cassette transporter 8; White protein homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNL
TEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPS
GAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV
SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFF
DEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGK
VCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD
AEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDS
VLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLE
MGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAAL
GTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYIS
YVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFI
SLRLIAYFVLRYKIRAER
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
ABC transporter superfamily, ABCG family, Eye pigment precursor importer (TC 3.A.1.204) subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol.
TTD ID
T47098
Uniprot ID
P45844
DrugMap ID
TTMWDGU
Ensemble ID
ENST00000343687.7
HGNC ID
HGNC:73

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C409(3.47)  LDD3313  [1]
CY4
 Probe Info  		N.A.  LDD0247  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C349(0.00); C209(0.00)  LDD0037  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C302(1.10)  LDD1513  [5]
 LDCM0283  AC23 HEK-293T C302(0.94)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C302(0.72)  LDD1523  [5]
 LDCM0292  AC31 HEK-293T C302(0.93)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C302(1.18)  LDD1532  [5]
 LDCM0300  AC39 HEK-293T C302(0.93)  LDD1539  [5]
 LDCM0302  AC40 HEK-293T C302(0.79)  LDD1541  [5]
 LDCM0309  AC47 HEK-293T C302(1.08)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C302(0.87)  LDD1549  [5]
 LDCM0318  AC55 HEK-293T C302(1.09)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C302(0.91)  LDD1558  [5]
 LDCM0327  AC63 HEK-293T C302(1.17)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C302(0.96)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C302(1.05)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C302(0.66)  LDD1569  [5]
 LDCM0275  AKOS034007705 HEK-293T C302(0.75)  LDD1514  [5]
 LDCM0379  CL11 HEK-293T C302(1.04)  LDD1583  [5]
 LDCM0390  CL12 HEK-293T C302(1.35)  LDD1594  [5]
 LDCM0411  CL23 HEK-293T C302(1.36)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C302(0.73)  LDD1616  [5]
 LDCM0424  CL35 HEK-293T C302(0.86)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C302(1.07)  LDD1629  [5]
 LDCM0437  CL47 HEK-293T C302(0.65)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C302(0.62)  LDD1642  [5]
 LDCM0450  CL59 HEK-293T C302(1.25)  LDD1653  [5]
 LDCM0452  CL60 HEK-293T C302(1.25)  LDD1655  [5]
 LDCM0464  CL71 HEK-293T C302(1.32)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C302(0.75)  LDD1668  [5]
 LDCM0477  CL83 HEK-293T C302(0.79)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C302(0.76)  LDD1681  [5]
 LDCM0490  CL95 HEK-293T C302(1.66)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C302(0.57)  LDD1694  [5]
 LDCM0022  KB02 769-P C409(1.85)  LDD2246  [1]
 LDCM0023  KB03 769-P C409(2.57)  LDD2663  [1]
 LDCM0024  KB05 Hs 936.T C409(3.47)  LDD3313  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-binding cassette sub-family G member 4 (ABCG4) ABCG family Q9H172
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vitamin E Small molecular drug DB00163
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atp Small molecular drug DB00171

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402