Details of the Target

General Information of Target

Target ID LDTP03425
Target Name Tropomodulin-1 (TMOD1)
Gene Name TMOD1
Gene ID 7111
Synonyms
D9S57E; TMOD; Tropomodulin-1; Erythrocyte tropomodulin; E-Tmod
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTG
PFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKPLDPVLESVTLEPELEEAL
ANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKEGLNSVIKPTQYKPVPDEEPNS
TDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPV
AYALAEMLKENKVLKTLNVESNFISGAGILRLVEALPYNTSLVEMKIDNQSQPLGNKVEM
EIVSMLEKNATLLKFGYHFTQQGPRLRASNAMMNNNDLVRKRRLADLTGPIIPKCRSGV
Target Bioclass
Other
Family
Tropomodulin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
Uniprot ID
P28289
Ensemble ID
ENST00000259365.9
HGNC ID
HGNC:11871

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.N309TfsTer24 .
HUH7 SNV: p.L187Q .
WM2664 Insertion: . .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C134
 Probe Info  		21.86  LDD1816  [1]
FFF probe13
 Probe Info  		13.96  LDD0476  [2]
FFF probe3
 Probe Info  		20.00  LDD0465  [2]

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
2 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.