Details of the Target

General Information of Target

Target ID LDTP03351
Target Name Paired box protein Pax-6 (PAX6)
Gene Name PAX6
Gene ID 5080
Synonyms
AN2; Paired box protein Pax-6; Aniridia type II protein; Oculorhombin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRY
YETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSV
SSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQ
EGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFAR
ERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIP
QPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPT
SPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPR
LQ
Target Bioclass
Transcription factor
Family
Paired homeobox family
Subcellular location
Nucleus
Function
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression.
Uniprot ID
P26367
Ensemble ID
ENST00000241001.13
HGNC ID
HGNC:8620

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C94(0.82); C40(1.23)  LDD3423  [1]
CY-1
 Probe Info  		W156(0.00); Q152(0.00)  LDD0246  [2]
IA-alkyne
 Probe Info  		C52(0.00); C94(0.00); C40(0.00)  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
W1
 Probe Info  		N150(0.00); Q152(0.00)  LDD0236  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C94(1.06)  LDD1507  [6]
 LDCM0237  AC12 HEK-293T C52(1.05)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C52(0.96); C94(0.81)  LDD1512  [6]
 LDCM0276  AC17 HEK-293T C94(1.13)  LDD1515  [6]
 LDCM0280  AC20 HEK-293T C52(0.98)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C94(0.93)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C52(0.88); C94(0.85)  LDD1521  [6]
 LDCM0284  AC24 HEK-293T C52(0.99); C94(0.98)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C94(0.94)  LDD1524  [6]
 LDCM0288  AC28 HEK-293T C52(1.07)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C94(1.06)  LDD1528  [6]
 LDCM0291  AC30 HEK-293T C52(0.98); C94(0.93)  LDD1530  [6]
 LDCM0293  AC32 HEK-293T C52(1.00); C94(1.05)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C94(1.14)  LDD1533  [6]
 LDCM0297  AC36 HEK-293T C52(1.13)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C94(1.15)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C52(1.05); C94(1.13)  LDD1538  [6]
 LDCM0301  AC4 HEK-293T C52(1.12)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C52(1.03); C94(1.01)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C94(1.13)  LDD1542  [6]
 LDCM0306  AC44 HEK-293T C52(1.13)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C94(0.99)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C52(0.97); C94(0.98)  LDD1547  [6]
 LDCM0310  AC48 HEK-293T C52(1.03); C94(0.94)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C94(1.15)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C94(1.24)  LDD1551  [6]
 LDCM0315  AC52 HEK-293T C52(1.02)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C94(1.16)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C52(0.99); C94(0.81)  LDD1556  [6]
 LDCM0319  AC56 HEK-293T C52(0.92); C94(0.99)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C94(1.07)  LDD1559  [6]
 LDCM0323  AC6 HEK-293T C52(0.97); C94(0.87)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C52(1.10)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C94(1.10)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C52(0.88); C94(0.91)  LDD1565  [6]
 LDCM0328  AC64 HEK-293T C52(1.11); C94(0.90)  LDD1567  [6]
 LDCM0345  AC8 HEK-293T C52(1.01); C94(0.86)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C94(1.05)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C94(1.11)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C52(1.06); C94(0.99)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C52(0.99)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C52(0.79); C94(0.67)  LDD1572  [6]
 LDCM0370  CL101 HEK-293T C52(0.87)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C52(0.85)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C52(0.95)  LDD1576  [6]
 LDCM0374  CL105 HEK-293T C52(1.03)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C52(1.10)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C52(0.96)  LDD1580  [6]
 LDCM0378  CL109 HEK-293T C52(1.05)  LDD1582  [6]
 LDCM0380  CL110 HEK-293T C52(0.94)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C52(0.98)  LDD1585  [6]
 LDCM0383  CL113 HEK-293T C52(1.27)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C52(1.29)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C52(1.02)  LDD1589  [6]
 LDCM0387  CL117 HEK-293T C52(0.91)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C52(1.00)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C52(0.96)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C52(1.01); C94(0.83)  LDD1594  [6]
 LDCM0392  CL121 HEK-293T C52(0.89)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C52(0.91)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C52(0.92)  LDD1598  [6]
 LDCM0396  CL125 HEK-293T C52(1.27)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C52(0.88)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C52(0.89)  LDD1602  [6]
 LDCM0400  CL13 HEK-293T C52(0.78)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C52(1.11)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C52(0.83)  LDD1606  [6]
 LDCM0404  CL17 HEK-293T C94(1.04)  LDD1608  [6]
 LDCM0407  CL2 HEK-293T C52(0.95)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C52(1.00)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C94(0.96)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C52(1.00); C94(0.95)  LDD1614  [6]
 LDCM0412  CL24 HEK-293T C52(0.88); C94(1.11)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C52(1.06)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C52(1.24)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C52(1.03)  LDD1619  [6]
 LDCM0417  CL29 HEK-293T C94(1.02)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C52(1.25)  LDD1622  [6]
 LDCM0421  CL32 HEK-293T C52(1.07)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C94(0.85)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C52(0.93); C94(1.02)  LDD1627  [6]
 LDCM0425  CL36 HEK-293T C52(0.93); C94(0.93)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C52(1.07)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C52(1.01)  LDD1632  [6]
 LDCM0431  CL41 HEK-293T C94(1.15)  LDD1635  [6]
 LDCM0434  CL44 HEK-293T C52(1.19)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C94(0.88)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C52(0.92); C94(0.88)  LDD1640  [6]
 LDCM0438  CL48 HEK-293T C52(1.03); C94(1.01)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C52(1.12)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C94(1.16)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C52(0.96)  LDD1645  [6]
 LDCM0444  CL53 HEK-293T C94(1.07)  LDD1647  [6]
 LDCM0447  CL56 HEK-293T C52(1.16)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C94(1.27)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C52(0.89); C94(0.88)  LDD1652  [6]
 LDCM0452  CL60 HEK-293T C52(1.03); C94(1.04)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C52(0.91)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C52(1.04)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C52(1.09)  LDD1658  [6]
 LDCM0457  CL65 HEK-293T C94(1.09)  LDD1660  [6]
 LDCM0460  CL68 HEK-293T C52(0.90)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C94(1.11)  LDD1664  [6]
 LDCM0463  CL70 HEK-293T C52(0.92); C94(0.96)  LDD1666  [6]
 LDCM0465  CL72 HEK-293T C52(1.18); C94(0.97)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C52(0.95)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C52(1.13)  LDD1670  [6]
 LDCM0470  CL77 HEK-293T C94(0.99)  LDD1673  [6]
 LDCM0473  CL8 HEK-293T C52(1.00)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C52(1.01)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C94(1.02)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C52(0.96); C94(1.01)  LDD1679  [6]
 LDCM0478  CL84 HEK-293T C52(0.88); C94(0.88)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C52(1.15)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C52(1.20)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C52(1.00)  LDD1684  [6]
 LDCM0483  CL89 HEK-293T C94(0.99)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C94(1.12)  LDD1687  [6]
 LDCM0487  CL92 HEK-293T C52(1.07)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C94(0.88)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C52(0.86); C94(0.99)  LDD1692  [6]
 LDCM0491  CL96 HEK-293T C52(1.08); C94(0.94)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C52(1.01)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C52(0.76)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C52(0.96)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C52(1.08)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C52(1.14)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C52(0.91)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C94(1.00)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C94(1.16)  LDD1497  [6]
 LDCM0024  KB05 SK-ES1 C94(0.82); C40(1.23)  LDD3423  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) 5'-AMP-activated protein kinase gamma subunit family P54619
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Peptidyl-prolyl cis-trans isomerase-like 4 (PPIL4) Cyclophilin-type PPIase family Q8WUA2
Deoxyhypusine synthase (DHPS) Deoxyhypusine synthase family P49366
DNA-directed RNA polymerase III subunit RPC3 (POLR3C) Eukaryotic RPC3/POLR3C RNA polymerase subunit family Q9BUI4
DNA-directed RNA polymerase III subunit RPC7-like (POLR3GL) Eukaryotic RPC7 RNA polymerase subunit family Q9BT43
Cyclin-dependent kinase 3 (CDK3) CMGC Ser/Thr protein kinase family Q00526
Serine/threonine-protein kinase tousled-like 1 (TLK1) Ser/Thr protein kinase family Q9UKI8
Serine/threonine-protein kinase tousled-like 2 (TLK2) Ser/Thr protein kinase family Q86UE8
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
E3 ubiquitin-protein ligase ARIH2 (ARIH2) RBR family O95376
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1) PNGase family Q96IV0
SUMO-activating enzyme subunit 1 (SAE1) Ubiquitin-activating E1 family Q9UBE0
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
NEDD8-conjugating enzyme UBE2F (UBE2F) Ubiquitin-conjugating enzyme family Q969M7
V-type proton ATPase subunit d 2 (ATP6V0D2) V-ATPase V0D/AC39 subunit family Q8N8Y2
Acetyl-coenzyme A thioesterase (ACOT12) . Q8WYK0
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Solute carrier family 12 member 8 (SLC12A8) SLC12A transporter family A0AV02
SEC14-like protein 4 (SEC14L4) . Q9UDX3
SH3 and cysteine-rich domain-containing protein (STAC) . Q99469
THO complex subunit 1 (THOC1) . Q96FV9
Uncharacterized protein CXorf38 (CXorf38) . Q8TB03
Transcription factor
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C9 (HOXC9) Abd-B homeobox family P31274
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Grainyhead-like protein 2 homolog (GRHL2) Grh/CP2 family Q6ISB3
High mobility group protein B3 (HMGB3) HMGB family O15347
Zinc finger protein 124 (ZNF124) Krueppel C2H2-type zinc-finger protein family Q15973
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Chorion-specific transcription factor GCMb (GCM2) . O75603
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-C motif chemokine 26 (CCL26) Intercrine beta (chemokine CC) family Q9Y258
Other
Click To Hide/Show 39 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 103 (CCDC103) CCDC103/PR46b family Q8IW40
Chromatin assembly factor 1 subunit A (CHAF1A) CHAF1A family Q13111
Cyclin-dependent kinase 2-interacting protein (CINP) CINP family Q9BW66
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) CKS family P61024
ELL-associated factor 1 (EAF1) EAF family Q96JC9
Probable RNA-binding protein EIF1AD (EIF1AD) EIF1AD family Q8N9N8
Protein FAM50B (FAM50B) FAM50 family Q9Y247
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Gem-associated protein 2 (GEMIN2) Gemin-2 family O14893
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Keratin-associated protein 9-8 (KRTAP9-8) KRTAP type 9 family Q9BYQ0
Microtubule-associated protein RP/EB family member 1 (MAPRE1) MAPRE family Q15691
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
Large ribosomal subunit protein mL53 (MRPL53) Mitochondrion-specific ribosomal protein mL53 family Q96EL3
Neurochondrin (NCDN) Neurochondrin family Q9UBB6
UBX domain-containing protein 2B (UBXN2B) NSFL1C family Q14CS0
Latexin (LXN) Protease inhibitor I47 (latexin) family Q9BS40
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
Speedy protein C (SPDYC) Speedy/Ringo family Q5MJ68
T-complex protein 11-like protein 1 (TCP11L1) TCP11 family Q9NUJ3
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Bcl-2-like protein 15 (BCL2L15) . Q5TBC7
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
CGG triplet repeat-binding protein 1 (CGGBP1) . Q9UFW8
Coiled-coil domain-containing protein 6 (CCDC6) . Q16204
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
LysM and putative peptidoglycan-binding domain-containing protein 1 (LYSMD1) . Q96S90
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
MORN repeat-containing protein 3 (MORN3) . Q6PF18
PRKCA-binding protein (PICK1) . Q9NRD5
Psoriasis susceptibility 1 candidate gene 2 protein (PSORS1C2) . Q9UIG4
UBX domain-containing protein 7 (UBXN7) . O94888

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402