Details of the Target

General Information of Target

Target ID LDTP02871
Target Name Zinc finger X-chromosomal protein (ZFX)
Gene Name ZFX
Gene ID 7543
Synonyms
Zinc finger X-chromosomal protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDEDGLELQQEPNSFFDATGADGTHMDGDQIVVEVQETVFVSDVVDSDITVHNFVPDDPD
SVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLAS
DITSASMSMPEHVLTGDSIHVSDVGHVGHVGHVEHVVHDSVVEAEIVTDPLTTDVVSEEV
LVADCASEAVIDANGIPVDQQDDDKGNCEDYLMISLDDAGKIEHDGSSGMTMDTESEIDP
CKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVY
MTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAW
AAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGH
PLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYRCTDCDYTTNKKISLHNHLESHKL
TSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLA
VHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHS
KEMPFKCDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDY
PHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFR
CKRCRKGFRQQSELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEY
CKKGFRRPSEKNQHIMRHHKEVGLP
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family, ZFX/ZFY subfamily
Subcellular location
Nucleus
Function Probable transcriptional activator.
Uniprot ID
P17010
Ensemble ID
ENST00000304543.10
HGNC ID
HGNC:12869

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R558H .
42MGBA SNV: p.T90M .
C4II SNV: p.M129V .
COLO792 SNV: p.S760L .
HEC1 Deletion: p.M689CfsTer17
SNV: p.D192G		 .
HEC1B Deletion: p.M689CfsTer17 .
MOLM13 Deletion: p.Y774SfsTer4 .
NALM6 SNV: p.R786Q .
TOV21G Deletion: p.M689CfsTer17 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K441(9.09)  LDD0277  [1]
DBIA
 Probe Info  		C247(2.05)  LDD0080  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C247(1.05)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C247(0.96)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C247(1.04); C208(0.93)  LDD1509  [3]
 LDCM0259  AC14 HEK-293T C247(0.91)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C247(1.05)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C247(1.04)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C247(1.02); C208(0.94)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C247(1.04)  LDD1518  [3]
 LDCM0281  AC21 HEK-293T C247(0.96)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C247(0.96)  LDD1521  [3]
 LDCM0284  AC24 HEK-293T C247(1.04); C208(0.94)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C247(1.04)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C247(1.12)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C247(0.99); C208(0.83)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C247(0.99)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C247(0.99); C208(0.92)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C247(0.97)  LDD1530  [3]
 LDCM0293  AC32 HEK-293T C247(1.03); C208(0.94)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C247(1.03)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C247(1.05)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C247(1.10); C208(0.89)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C247(0.94)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C247(0.96)  LDD1538  [3]
 LDCM0302  AC40 HEK-293T C247(1.14); C208(0.90)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C247(1.05)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C247(1.05)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C247(0.95); C208(1.11)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C247(0.92)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C247(1.15)  LDD1547  [3]
 LDCM0310  AC48 HEK-293T C247(1.04); C208(0.87)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C247(0.99)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C247(0.92)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C247(0.93)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C247(0.93); C208(0.97)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C247(0.90)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C247(1.06)  LDD1556  [3]
 LDCM0319  AC56 HEK-293T C247(1.10); C208(1.00)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C247(1.09)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C247(0.98)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C247(1.09); C208(1.06)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C247(1.05)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C247(0.91)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C247(0.96)  LDD1565  [3]
 LDCM0328  AC64 HEK-293T C247(1.03); C208(1.02)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C247(1.08); C208(0.96)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C247(0.87)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C247(0.99)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C247(1.05); C208(0.97)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C247(1.05)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C247(1.24)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C247(1.35)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C247(1.26)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C247(1.05)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C247(1.03)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C247(1.16)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C247(1.43)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C247(0.96)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C247(1.18)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C247(0.97)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C247(1.07)  LDD1582  [3]
 LDCM0380  CL110 HEK-293T C247(1.00)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C247(1.00)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C247(1.34)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C247(1.28)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C247(1.01)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C247(1.17)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C247(0.97)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C247(0.97)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C247(1.13)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C247(1.14)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C247(1.17); C208(1.07)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C247(1.19)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C247(1.06)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C247(1.03)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C247(1.00)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C247(1.02)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C247(1.23)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C247(1.07)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C247(1.09)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C247(1.14)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C247(1.13)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C247(1.06)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C247(0.98)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C247(1.03)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C247(1.05)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C247(0.99)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C247(0.98); C208(1.07)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C247(1.04)  LDD1611  [3]
 LDCM0409  CL21 HEK-293T C247(1.05)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C247(1.17)  LDD1614  [3]
 LDCM0412  CL24 HEK-293T C247(1.20); C208(1.22)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C247(1.06)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C247(1.03)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C247(1.08)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C247(1.01)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C247(1.08)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C247(0.97)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C247(0.96)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C247(0.99); C208(0.92)  LDD1624  [3]
 LDCM0422  CL33 HEK-293T C247(0.96)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C247(1.12)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C247(1.34); C208(1.72)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C247(1.17)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C247(1.03)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C247(1.03)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C247(0.90)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C247(1.01)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C247(1.12)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C247(1.08); C208(0.89)  LDD1637  [3]
 LDCM0435  CL45 HEK-293T C247(1.06)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C247(1.12)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C247(1.31); C208(1.62)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C247(1.20)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C247(1.05)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C247(1.05)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C247(1.31)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C247(0.96)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C247(1.08)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C247(1.16); C208(1.09)  LDD1649  [3]
 LDCM0448  CL57 HEK-293T C247(1.20)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C247(1.11)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C247(1.03)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C247(1.43); C208(1.41)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C247(1.22)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C247(1.06)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C247(1.11)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C247(1.01)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C247(1.03)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C247(1.06)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C247(1.03); C208(0.97)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C247(0.95)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C247(1.05); C208(0.91)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C247(1.08)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C247(1.18); C208(1.32)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C247(1.35)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C247(0.99)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C247(0.95)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C247(1.07)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C247(1.02)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C247(1.01); C208(0.97)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C247(0.96)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C247(1.13)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C247(1.22); C208(1.09)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C247(1.01)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C247(0.96)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C247(1.04)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C247(0.96)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C247(1.02)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C247(1.07)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C247(0.95)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C247(1.01); C208(0.99)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C247(1.02)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C247(1.06)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C247(1.10); C208(0.88)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C247(1.28)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C247(1.05)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C247(1.11)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C247(1.15)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C247(1.02)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C247(1.09)  LDD1631  [3]
 LDCM0022  KB02 HCT 116 C247(2.05)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C247(1.37)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C247(1.38)  LDD0082  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402