Details of the Target

General Information of Target

Target ID LDTP02808
Target Name Paired box protein Pax-1 (PAX1)
Gene Name PAX1
Gene ID 5075
Synonyms
HUP48; Paired box protein Pax-1; HuP48
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKFTLGLGSRAWRVSWEGAAAAAAGPGAGGSALRCRAQRVSSPRLGRRGSRLSGALPLCL
SRGGGGAQALPDCAGPSPGHPGHPGARQLAGPLAMEQTYGEVNQLGGVFVNGRPLPNAIR
LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPNVVKH
IRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGSLAQPGPYEASKQP
PSQPTLPYNHIYQYPYPSPVSPTGAKMGSHPGVPGTAGHVSIPRSWPSAHSVSNILGIRT
FMEQTGALAGSEGTAYSPKMEDWAGVNRTAFPATPAVNGLEKPALEADIKYTQSASTLSA
VGGFLPACAYPASNQHGVYSAPGGGYLAPGPPWPPAQGPPLAPPGAGVAVHGGELAAAMT
FKHPSREGSLPAPAARPRTPSVAYTDCPSRPRPPRGSSPRTRARRERQADPGAQVCAAAP
AIGTGRIGGLAEEEASAGPRGARPASPQAQPCLWPDPPHFLYWSGFLGFSELGF
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column.
Uniprot ID
P15863
Ensemble ID
ENST00000398485.6
HGNC ID
HGNC:8615

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C59(0.34)  LDD2227  [1]
DBIA
 Probe Info  		C134(0.99)  LDD1492  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C146(0.96)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C146(1.07)  LDD1510  [2]
 LDCM0278  AC19 HEK-293T C146(1.20)  LDD1517  [2]
 LDCM0280  AC20 HEK-293T C146(1.06)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C146(1.00)  LDD1520  [2]
 LDCM0284  AC24 HEK-293T C146(1.02)  LDD1523  [2]
 LDCM0287  AC27 HEK-293T C146(1.00)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C146(1.01)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C146(1.01)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C146(0.97)  LDD1529  [2]
 LDCM0293  AC32 HEK-293T C146(1.03)  LDD1532  [2]
 LDCM0296  AC35 HEK-293T C146(1.00)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C146(1.11)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C146(1.04)  LDD1537  [2]
 LDCM0301  AC4 HEK-293T C146(1.06)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C146(1.13)  LDD1541  [2]
 LDCM0305  AC43 HEK-293T C146(0.99)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C146(1.10)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C146(1.02)  LDD1546  [2]
 LDCM0310  AC48 HEK-293T C146(1.05)  LDD1549  [2]
 LDCM0312  AC5 HEK-293T C146(1.13)  LDD1551  [2]
 LDCM0314  AC51 HEK-293T C146(0.97)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C146(1.06)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C146(1.01)  LDD1555  [2]
 LDCM0319  AC56 HEK-293T C146(1.06)  LDD1558  [2]
 LDCM0322  AC59 HEK-293T C146(1.01)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C146(1.06)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C146(1.08)  LDD1564  [2]
 LDCM0328  AC64 HEK-293T C146(1.00)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C146(1.04)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C146(1.11)  LDD1511  [2]
 LDCM0275  AKOS034007705 HEK-293T C146(1.02)  LDD1514  [2]
 LDCM0632  CL-Sc Hep-G2 C59(0.34)  LDD2227  [1]
 LDCM0369  CL100 HEK-293T C146(0.82)  LDD1573  [2]
 LDCM0373  CL104 HEK-293T C146(0.71)  LDD1577  [2]
 LDCM0377  CL108 HEK-293T C146(0.74)  LDD1581  [2]
 LDCM0382  CL112 HEK-293T C146(0.69)  LDD1586  [2]
 LDCM0386  CL116 HEK-293T C146(0.90)  LDD1590  [2]
 LDCM0390  CL12 HEK-293T C146(1.13)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C146(1.05)  LDD1595  [2]
 LDCM0395  CL124 HEK-293T C146(0.78)  LDD1599  [2]
 LDCM0399  CL128 HEK-293T C146(0.77)  LDD1603  [2]
 LDCM0403  CL16 HEK-293T C146(0.69)  LDD1607  [2]
 LDCM0406  CL19 HEK-293T C146(1.03)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C146(1.23)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C146(1.20)  LDD1613  [2]
 LDCM0412  CL24 HEK-293T C146(1.01)  LDD1616  [2]
 LDCM0416  CL28 HEK-293T C146(0.61)  LDD1620  [2]
 LDCM0420  CL31 HEK-293T C146(1.05)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C146(1.09)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C146(1.09)  LDD1626  [2]
 LDCM0425  CL36 HEK-293T C146(1.10)  LDD1629  [2]
 LDCM0429  CL4 HEK-293T C146(0.78)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C146(1.07)  LDD1634  [2]
 LDCM0433  CL43 HEK-293T C146(1.06)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C146(1.06)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C146(1.15)  LDD1639  [2]
 LDCM0438  CL48 HEK-293T C146(1.04)  LDD1642  [2]
 LDCM0443  CL52 HEK-293T C146(0.93)  LDD1646  [2]
 LDCM0446  CL55 HEK-293T C146(0.97)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C146(1.20)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C146(1.31)  LDD1651  [2]
 LDCM0452  CL60 HEK-293T C146(1.11)  LDD1655  [2]
 LDCM0456  CL64 HEK-293T C146(0.83)  LDD1659  [2]
 LDCM0459  CL67 HEK-293T C146(1.01)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C146(1.09)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C146(1.13)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C146(1.02)  LDD1665  [2]
 LDCM0465  CL72 HEK-293T C146(1.21)  LDD1668  [2]
 LDCM0469  CL76 HEK-293T C146(0.85)  LDD1672  [2]
 LDCM0472  CL79 HEK-293T C146(1.05)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C146(2.12)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C146(1.06)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C146(1.07)  LDD1678  [2]
 LDCM0478  CL84 HEK-293T C146(1.14)  LDD1681  [2]
 LDCM0482  CL88 HEK-293T C146(0.69)  LDD1685  [2]
 LDCM0484  CL9 HEK-293T C146(1.16)  LDD1687  [2]
 LDCM0486  CL91 HEK-293T C146(1.03)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C146(1.11)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C146(1.05)  LDD1691  [2]
 LDCM0491  CL96 HEK-293T C146(1.10)  LDD1694  [2]
 LDCM0022  KB02 HEK-293T C134(0.99)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C134(1.05)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C134(0.95)  LDD1502  [2]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402