Details of the Target

General Information of Target

Target ID LDTP02806
Target Name Zinc finger protein 40 (HIVEP1)
Gene Name HIVEP1
Gene ID 3096
Synonyms
ZNF40; Zinc finger protein 40; Cirhin interaction protein; CIRIP; Gate keeper of apoptosis-activating protein; GAAP; Human immunodeficiency virus type I enhancer-binding protein 1; HIV-EP1; Major histocompatibility complex-binding protein 1; MBP-1; Positive regulatory domain II-binding factor 1; PRDII-BF1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRTKQIHPRNLRDKIEEAQKELNGAEVSKKEILQAGVKGTSESLKGVKRKKIVAENHLK
KIPKSPLRNPLQAKHKQNTEESSFAVLHSASESHKKQNYIPVKNGKQFTKQNGETPGIIA
EASKSEESVSPKKPLFLQQPSELRRWRSEGADPAKFSDLDEQCDSSSLSSKTRTDNSECI
SSHCGTTSPSYTNTAFDVLLKAMEPELSTLSQKGSPCAIKTEKLRPNKTARSPPKLKNSS
MDAPNQTSQELVAESQSSCTSYTVHMSAAQKNEQGAMQSASHLYHQHEHFVPKSNQHNQQ
LPGCSGFTGSLTNLQNQENAKLEQVYNIAVTSSVGLTSPSSRSQVTPQNQQMDSASPLSI
SPANSTQSPPMPIYNSTHVASVVNQSVEQMCNLLLKDQKPKKQGKYICEYCNRACAKPSV
LLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKLGLVLQPDAGGLFLSHESP
KALSIHSDVEDSGESEEEGATDERQHDLGAMELQPVHIIKRMSNAETLLKSSFTPSSPEN
VIGDFLLQDRSAESQAVTELPKVVVHHVTVSPLRTDSPKAMDPKPELSSAQKQKDLQVTN
VQPLSANMSQGGVSRLETNENSHQKGDMNPLEGKQDSHVGTVHAQLQRQQATDYSQEQQG
KLLSPRSLGSTDSGYFSRSESADQTVSPPTPFARRLPSTEQDSGRSNGPSAALVTTSTPS
ALPTGEKALLLPGQMRPPLATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSI
DSPKSYIFKDSFQFDLKPVGRRTSSSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSN
SMPTTGYSAVPANIIPPPHPLRGSQSFDDKIGAFYDDVFVSGPNAPVPQSGHPRTLVRQA
AIEDSSANESHVLGTGQSLDESHQGCHAAGEAMSVRSKALAQGPHIEKKKSHQGRGTMFE
CETCRNRYRKLENFENHKKFYCSELHGPKTKVAMREPEHSPVPGGLQPQILHYRVAGSSG
IWEQTPQIRKRRKMKSVGDDEELQQNESGTSPKSSEGLQFQNALGCNPSLPKHNVTIRSD
QQHKNIQLQNSHIHLVARGPEQTMDPKLSTIMEQQISSAAQDKIELQRHGTGISVIQHTN
SLSRPNSFDKPEPFERASPVSFQELNRTGKSGSLKVIGISQEESHPSRDGSHPHQLALSD
ALRGELQESSRKSPSERHVLGQPSRLVRQHNIQVPEILVTEEPDRDLEAQCHDQEKSEKF
SWPQRSETLSKLPTEKLPPKKKRLRLAEIEHSSTESSFDSTLSRSLSRESSLSHTSSFSA
SLDIEDVSKTEASPKIDFLNKAEFLMIPAGLNTLNVPGCHREMRRTASEQINCTQTSMEV
SDLRSKSFDCGSITPPQTTPLTELQPPSSPSRVGVTGHVPLLERRRGPLVRQISLNIAPD
SHLSPVHPTSFQNTALPSVNAVPYQGPQLTSTSLAEFSANTLHSQTQVKDLQAETSNSSS
TNVFPVQQLCDINLLNQIHAPPSHQSTQLSLQVSTQGSKPDKNSVLSGSSKSEDCFAPKY
QLHCQVFTSGPSCSSNPVHSLPNQVISDPVGTDHCVTSATLPTKLIDSMSNSHPLLPPEL
RPLGSQVQKVPSSFMLPIRLQSSVPAYCFATLTSLPQILVTQDLPNQPICQTNHSVVPIS
EEQNSVPTLQKGHQNALPNPEKEFLCENVFSEMSQNSSLSESLPITQKISVGRLSPQQES
SASSKRMLSPANSLDIAMEKHQKRAKDENGAVCATDVRPLEALSSRVNEASKQKKPILVR
QVCTTEPLDGVMLEKDVFSQPEISNEAVNLTNVLPADNSSTGCSKFVVIEPISELQEFEN
IKSSTSLTLTVRSSPAPSENTHISPLKCTDNNQERKSPGVKNQGDKVNIQEQSQQPVTSL
SLFNIKDTQQLAFPSLKTTTNFTWCYLLRQKSLHLPQKDQKTSAYTDWTVSASNPNPLGL
PTKVALALLNSKQNTGKSLYCQAITTHSKSDLLVYSSKWKSSLSKRALGNQKSTVVEFSN
KDASEINSEQDKENSLIKSEPRRIKIFDGGYKSNEEYVYVRGRGRGKYICEECGIRCKKP
SMLKKHIRTHTDVRPYHCTYCNFSFKTKGNLTKHMKSKAHSKKCVDLGVSVGLIDEQDTE
ESDEKQRFSYERSGYDLEESDGPDEDDNENEDDDEDSQAESVLSATPSVTASPQHLPSRS
SLQDPVSTDEDVRITDCFSGVHTDPMDVLPRALLTRMTVLSTAQSDYNRKTLSPGKARQR
AARDENDTIPSVDTSRSPCHQMSVDYPESEEILRSSMAGKAVAITQSPSSVRLPPAAAEH
SPQTAAGMPSVASPHPDPQEQKQQITLQPTPGLPSPHTHLFSHLPLHSQQQSRTPYNMVP
VGGIHVVPAGLTYSTFVPLQAGPVQLTIPAVSVVHRTLGTHRNTVTEVSGTTNPAGVAEL
SSVVPCIPIGQIRVPGLQNLSTPGLQSLPSLSMETVNIVGLANTNMAPQVHPPGLALNAV
GLQVLTANPSSQSSPAPQAHIPGLQILNIALPTLIPSVSQVAVDAQGAPEMPASQSKACE
TQPKQTSVASANQVSRTESPQGLPTVQRENAKKVLNPPAPAGDHARLDGLSKMDTEKAAS
ANHVKPKPELTSIQGQPASTSQPLLKAHSEVFTKPSGQQTLSPDRQVPRPTALPRRQPTV
HFSDVSSDDDEDRLVIAT
Target Bioclass
Transcription factor
Subcellular location
Cytoplasm; Nucleus
Function
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
Uniprot ID
P15822
Ensemble ID
ENST00000379388.7
HGNC ID
HGNC:4920
ChEMBL ID
CHEMBL2909

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.I1021M .
COLO678 SNV: p.E2092Q .
COLO792 SNV: p.Q1207Ter DBIA    Probe Info 
DANG SNV: p.D1299E .
DU145 SNV: p.D1189G .
IM95 Insertion: p.Q403TfsTer7 .
KU1919 SNV: p.Q1061Ter .
LNCaP clone FGC SNV: p.D1080G .
MEWO SNV: p.P70S; p.R862K .
MFE319 Deletion: p.E32KfsTer17
Insertion: p.V2614SfsTer10		 .
OVISE SNV: p.D2709Y .
OVK18 Deletion: p.I2404SfsTer57 .
RL952 SNV: p.Q246H; p.S2392L DBIA    Probe Info 
SHP77 SNV: p.A1650D .
SNGM Deletion: p.V2614FfsTer2
SNV: p.C2118Y		 .
SNU308 SNV: p.S354C .
TF1 SNV: p.K970Ter .
TFK1 SNV: p.V880L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C1251(0.81)  LDD2227  [1]
DBIA
 Probe Info  		C1888(1.53)  LDD0080  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]
IPM
 Probe Info  		C2001(0.00); C304(0.00); C1888(0.00); C2579(0.00)  LDD0147  [3]
YN-1
 Probe Info  		N.A.  LDD0447  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C2237(1.33)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C2237(1.02); C926(1.09)  LDD1509  [5]
 LDCM0270  AC15 HEK-293T C2237(1.09); C1888(1.20)  LDD1513  [5]
 LDCM0277  AC18 HEK-293T C2237(1.20)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C2237(1.25); C926(1.17)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C2237(1.04)  LDD1518  [5]
 LDCM0281  AC21 HEK-293T C2237(0.85); C1888(0.95)  LDD1520  [5]
 LDCM0283  AC23 HEK-293T C2237(1.07); C1888(1.28)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C2237(0.88); C1359(1.01)  LDD1523  [5]
 LDCM0286  AC26 HEK-293T C2237(1.07)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C2237(1.08); C926(1.16)  LDD1526  [5]
 LDCM0289  AC29 HEK-293T C2237(0.92); C1888(1.08)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C2237(1.10); C926(0.95)  LDD1529  [5]
 LDCM0292  AC31 HEK-293T C2237(1.14); C1888(1.00)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C2237(0.97); C1359(0.91)  LDD1532  [5]
 LDCM0295  AC34 HEK-293T C2237(1.27)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C2237(1.08); C926(1.36)  LDD1535  [5]
 LDCM0298  AC37 HEK-293T C2237(0.96); C1888(1.01)  LDD1537  [5]
 LDCM0300  AC39 HEK-293T C2237(1.11); C1888(1.03)  LDD1539  [5]
 LDCM0302  AC40 HEK-293T C2237(0.89); C1359(0.98)  LDD1541  [5]
 LDCM0304  AC42 HEK-293T C2237(1.12)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C2237(1.10); C926(0.75)  LDD1544  [5]
 LDCM0307  AC45 HEK-293T C2237(0.97); C1888(1.26)  LDD1546  [5]
 LDCM0309  AC47 HEK-293T C2237(1.25); C1888(1.05)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C2237(0.97); C1359(1.09)  LDD1549  [5]
 LDCM0312  AC5 HEK-293T C2237(1.15); C1888(1.15)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C2237(1.18)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C2237(0.94); C926(1.01)  LDD1553  [5]
 LDCM0316  AC53 HEK-293T C2237(1.01); C1888(0.98)  LDD1555  [5]
 LDCM0318  AC55 HEK-293T C2237(1.15); C1888(0.98)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C2237(1.21); C1359(0.93)  LDD1558  [5]
 LDCM0321  AC58 HEK-293T C2237(1.33)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C2237(1.19); C926(0.94)  LDD1561  [5]
 LDCM0325  AC61 HEK-293T C2237(0.85); C1888(1.10)  LDD1564  [5]
 LDCM0327  AC63 HEK-293T C2237(1.42); C1888(1.03)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C2237(1.26); C1359(1.06)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C2237(1.06); C1888(0.96)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C2237(0.99); C1359(0.97)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C2237(0.96); C1888(1.23)  LDD1511  [5]
 LDCM0275  AKOS034007705 HEK-293T C2237(0.99); C1359(1.11)  LDD1514  [5]
 LDCM0632  CL-Sc Hep-G2 C1251(0.81)  LDD2227  [1]
 LDCM0369  CL100 HEK-293T C2237(0.95); C1888(0.79); C1359(0.82)  LDD1573  [5]
 LDCM0371  CL102 HEK-293T C2237(1.17)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C1888(0.96)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C2237(1.01); C1888(0.99); C1359(1.03)  LDD1577  [5]
 LDCM0375  CL106 HEK-293T C2237(1.11)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C1888(1.01)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C2237(0.95); C1888(1.08); C1359(0.99)  LDD1581  [5]
 LDCM0379  CL11 HEK-293T C2237(1.34); C1888(1.41)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C2237(1.05)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C1888(1.06)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C2237(1.05); C1888(1.01); C1359(0.99)  LDD1586  [5]
 LDCM0384  CL114 HEK-293T C2237(0.95)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C1888(0.82)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C2237(1.03); C1888(0.78); C1359(0.91)  LDD1590  [5]
 LDCM0388  CL118 HEK-293T C2237(1.14)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C1888(0.82)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C2237(0.90); C1359(1.00)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C2237(1.03); C1888(0.93); C1359(0.97)  LDD1595  [5]
 LDCM0393  CL122 HEK-293T C2237(1.12)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C1888(1.01)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C2237(1.27); C1888(0.98); C1359(1.07)  LDD1599  [5]
 LDCM0397  CL126 HEK-293T C2237(1.19)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C1888(1.16)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C2237(1.08); C1888(1.00); C1359(1.17)  LDD1603  [5]
 LDCM0401  CL14 HEK-293T C2237(1.12)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C1888(0.88)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C2237(1.41); C1888(0.80); C1359(1.11)  LDD1607  [5]
 LDCM0405  CL18 HEK-293T C2237(1.17)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C2237(1.16); C926(0.97)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C2237(1.16)  LDD1611  [5]
 LDCM0409  CL21 HEK-293T C2237(1.01); C1888(1.17)  LDD1613  [5]
 LDCM0411  CL23 HEK-293T C2237(1.15); C1888(1.02)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C2237(0.96); C1359(0.97)  LDD1616  [5]
 LDCM0414  CL26 HEK-293T C2237(1.11)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C1888(0.91)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C2237(1.10); C1888(0.92); C1359(0.97)  LDD1620  [5]
 LDCM0418  CL3 HEK-293T C1888(0.96)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C2237(1.20)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C2237(0.79); C926(1.03)  LDD1624  [5]
 LDCM0422  CL33 HEK-293T C2237(1.03); C1888(0.98)  LDD1626  [5]
 LDCM0424  CL35 HEK-293T C2237(1.17); C1888(1.04)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C2237(1.12); C1359(1.13)  LDD1629  [5]
 LDCM0428  CL39 HEK-293T C1888(1.03)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C2237(1.32); C1888(0.88); C1359(1.06)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C2237(1.55); C1888(1.07); C1359(0.87)  LDD1634  [5]
 LDCM0432  CL42 HEK-293T C2237(1.05)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C2237(1.07); C926(0.96)  LDD1637  [5]
 LDCM0435  CL45 HEK-293T C2237(1.05); C1888(0.92)  LDD1639  [5]
 LDCM0437  CL47 HEK-293T C2237(1.26); C1888(1.15)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C2237(1.00); C1359(1.07)  LDD1642  [5]
 LDCM0441  CL50 HEK-293T C2237(1.10)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C2237(1.20); C1888(1.14); C1359(0.95)  LDD1646  [5]
 LDCM0445  CL54 HEK-293T C2237(1.14)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C2237(1.01); C926(1.17)  LDD1649  [5]
 LDCM0448  CL57 HEK-293T C2237(1.14); C1888(1.14)  LDD1651  [5]
 LDCM0450  CL59 HEK-293T C2237(0.98); C1888(1.19)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C2237(1.12)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C2237(0.98); C1359(1.05)  LDD1655  [5]
 LDCM0454  CL62 HEK-293T C2237(1.17)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C1888(0.81)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C2237(1.16); C1888(1.15); C1359(1.09)  LDD1659  [5]
 LDCM0458  CL66 HEK-293T C2237(1.09)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C2237(1.12); C926(0.98)  LDD1662  [5]
 LDCM0461  CL69 HEK-293T C2237(1.00); C1888(1.43)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C2237(1.00); C926(1.04)  LDD1665  [5]
 LDCM0464  CL71 HEK-293T C2237(1.45); C1888(0.95)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C2237(0.87); C1359(1.06)  LDD1668  [5]
 LDCM0467  CL74 HEK-293T C2237(1.01)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C2237(1.14); C1888(1.14); C1359(1.01)  LDD1672  [5]
 LDCM0471  CL78 HEK-293T C2237(0.97)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C2237(1.19); C926(1.34)  LDD1675  [5]
 LDCM0475  CL81 HEK-293T C2237(1.03); C1888(1.41)  LDD1678  [5]
 LDCM0477  CL83 HEK-293T C2237(1.12); C1888(1.02)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C2237(0.85); C1359(1.05)  LDD1681  [5]
 LDCM0480  CL86 HEK-293T C2237(1.04)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C1888(0.91)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C2237(1.26); C1888(0.92); C1359(1.01)  LDD1685  [5]
 LDCM0484  CL9 HEK-293T C2237(1.00); C1888(1.03)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C2237(1.08)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C2237(0.97); C926(1.13)  LDD1689  [5]
 LDCM0488  CL93 HEK-293T C2237(0.82); C1888(0.93)  LDD1691  [5]
 LDCM0490  CL95 HEK-293T C2237(1.14); C1888(0.86)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C2237(0.80); C1359(1.12)  LDD1694  [5]
 LDCM0493  CL98 HEK-293T C2237(1.19)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C1888(1.85)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C1888(0.77)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C1888(0.86)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C2237(1.25)  LDD1631  [5]
 LDCM0022  KB02 HCT 116 C1888(1.53)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C1888(1.52)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C1888(1.38)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) Calcium channel alpha-1 subunit (TC 1.A.1.11) family O00555
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
U3 small nucleolar RNA-associated protein 4 homolog (UTP4) . Q969X6

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402