Details of the Target

General Information of Target

Target ID LDTP02714
Target Name Folate receptor beta (FOLR2)
Gene Name FOLR2
Gene ID 2350
Synonyms
Folate receptor beta; FR-beta; Folate receptor 2; Folate receptor, fetal/placental; Placental folate-binding protein; FBP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACC
TASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRK
ERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPA
ALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGG
LLLSLALMLQLWLLG
Target Type
Literature-reported
Target Bioclass
Other
Family
Folate receptor family
Subcellular location
Cell membrane
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
TTD ID
T82297
Uniprot ID
P14207
DrugMap ID
TTT54CI
Ensemble ID
ENST00000298223.11
HGNC ID
HGNC:3793
ChEMBL ID
CHEMBL5064

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C129(1.48)  LDD3332  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C129(1.06)  LDD1508  [2]
 LDCM0237  AC12 HEK-293T C129(0.96)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C129(1.06)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C129(1.10)  LDD1513  [2]
 LDCM0277  AC18 HEK-293T C129(1.09)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C129(1.00)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C129(0.90)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C129(1.11)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C129(1.34)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C129(1.20)  LDD1522  [2]
 LDCM0286  AC26 HEK-293T C129(1.11)  LDD1525  [2]
 LDCM0288  AC28 HEK-293T C129(0.98)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C129(1.37)  LDD1528  [2]
 LDCM0291  AC30 HEK-293T C129(0.94)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C129(0.94)  LDD1531  [2]
 LDCM0295  AC34 HEK-293T C129(0.93)  LDD1534  [2]
 LDCM0297  AC36 HEK-293T C129(0.96)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C129(0.94)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C129(0.97)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C129(1.28)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C129(0.84)  LDD1540  [2]
 LDCM0304  AC42 HEK-293T C129(1.32)  LDD1543  [2]
 LDCM0306  AC44 HEK-293T C129(1.02)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C129(1.02)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C129(1.21)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C129(1.01)  LDD1548  [2]
 LDCM0312  AC5 HEK-293T C129(1.39)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C129(1.15)  LDD1552  [2]
 LDCM0315  AC52 HEK-293T C129(1.03)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C129(1.00)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C129(0.98)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C129(0.84)  LDD1557  [2]
 LDCM0321  AC58 HEK-293T C129(1.36)  LDD1560  [2]
 LDCM0323  AC6 HEK-293T C129(1.01)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C129(1.12)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C129(1.26)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C129(1.08)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C129(1.20)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C129(0.84)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C129(1.07)  LDD1511  [2]
 LDCM0368  CL10 HEK-293T C129(0.72)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C129(1.21)  LDD1573  [2]
 LDCM0371  CL102 HEK-293T C129(1.04)  LDD1575  [2]
 LDCM0373  CL104 HEK-293T C129(1.26)  LDD1577  [2]
 LDCM0375  CL106 HEK-293T C129(1.14)  LDD1579  [2]
 LDCM0377  CL108 HEK-293T C129(0.90)  LDD1581  [2]
 LDCM0379  CL11 HEK-293T C129(0.88)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C129(0.96)  LDD1584  [2]
 LDCM0382  CL112 HEK-293T C129(1.11)  LDD1586  [2]
 LDCM0384  CL114 HEK-293T C129(1.38)  LDD1588  [2]
 LDCM0386  CL116 HEK-293T C129(1.01)  LDD1590  [2]
 LDCM0388  CL118 HEK-293T C129(1.16)  LDD1592  [2]
 LDCM0391  CL120 HEK-293T C129(1.45)  LDD1595  [2]
 LDCM0393  CL122 HEK-293T C129(0.78)  LDD1597  [2]
 LDCM0395  CL124 HEK-293T C129(0.85)  LDD1599  [2]
 LDCM0397  CL126 HEK-293T C129(0.89)  LDD1601  [2]
 LDCM0399  CL128 HEK-293T C129(1.07)  LDD1603  [2]
 LDCM0401  CL14 HEK-293T C129(0.77)  LDD1605  [2]
 LDCM0403  CL16 HEK-293T C129(1.03)  LDD1607  [2]
 LDCM0405  CL18 HEK-293T C129(1.27)  LDD1609  [2]
 LDCM0407  CL2 HEK-293T C129(1.14)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C129(1.00)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C129(1.06)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C129(0.91)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C129(1.18)  LDD1615  [2]
 LDCM0414  CL26 HEK-293T C129(1.10)  LDD1618  [2]
 LDCM0416  CL28 HEK-293T C129(3.19)  LDD1620  [2]
 LDCM0419  CL30 HEK-293T C129(0.96)  LDD1623  [2]
 LDCM0421  CL32 HEK-293T C129(0.77)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C129(0.89)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C129(1.09)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C129(1.13)  LDD1628  [2]
 LDCM0429  CL4 HEK-293T C129(0.17)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C129(1.11)  LDD1634  [2]
 LDCM0432  CL42 HEK-293T C129(1.16)  LDD1636  [2]
 LDCM0434  CL44 HEK-293T C129(0.99)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C129(0.94)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C129(1.14)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C129(1.21)  LDD1641  [2]
 LDCM0441  CL50 HEK-293T C129(0.58)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C129(1.14)  LDD1646  [2]
 LDCM0445  CL54 HEK-293T C129(0.84)  LDD1648  [2]
 LDCM0447  CL56 HEK-293T C129(0.98)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C129(1.31)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C129(1.01)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C129(1.06)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C129(1.29)  LDD1654  [2]
 LDCM0454  CL62 HEK-293T C129(0.93)  LDD1657  [2]
 LDCM0456  CL64 HEK-293T C129(1.16)  LDD1659  [2]
 LDCM0458  CL66 HEK-293T C129(1.29)  LDD1661  [2]
 LDCM0460  CL68 HEK-293T C129(0.83)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C129(1.03)  LDD1664  [2]
 LDCM0463  CL70 HEK-293T C129(0.95)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C129(1.01)  LDD1667  [2]
 LDCM0467  CL74 HEK-293T C129(0.97)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C129(1.18)  LDD1672  [2]
 LDCM0471  CL78 HEK-293T C129(1.46)  LDD1674  [2]
 LDCM0473  CL8 HEK-293T C129(0.76)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C129(1.13)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C129(0.90)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C129(1.13)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C129(1.21)  LDD1680  [2]
 LDCM0480  CL86 HEK-293T C129(1.19)  LDD1683  [2]
 LDCM0482  CL88 HEK-293T C129(1.33)  LDD1685  [2]
 LDCM0484  CL9 HEK-293T C129(1.17)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C129(0.82)  LDD1688  [2]
 LDCM0487  CL92 HEK-293T C129(0.96)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C129(1.28)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C129(0.96)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C129(0.81)  LDD1693  [2]
 LDCM0493  CL98 HEK-293T C129(0.88)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C129(1.01)  LDD1631  [2]
 LDCM0022  KB02 769-P C129(1.23)  LDD2246  [1]
 LDCM0023  KB03 769-P C129(1.70)  LDD2663  [1]
 LDCM0024  KB05 MKN45 C129(1.48)  LDD3332  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Folic Acid Small molecular drug DB00158
Methotrexate Small molecular drug DB00563
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vintafolide . DB05168

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402