Details of the Target

General Information of Target

Target ID LDTP02513
Target Name Tissue factor pathway inhibitor (TFPI)
Gene Name TFPI
Gene ID 7035
Synonyms
LACI; TFPI1; Tissue factor pathway inhibitor; TFPI; Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor; LACI
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADD
GPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQE
KPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPN
GFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIG
KCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIF
VKNM
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Secreted; Microsome membrane
Function
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
TTD ID
T78890
Uniprot ID
P10646
DrugMap ID
TT068JH
Ensemble ID
ENST00000233156.9
HGNC ID
HGNC:11760
ChEMBL ID
CHEMBL3713062

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 Insertion: p.M103NfsTer6 DBIA    Probe Info 
NUGC3 Deletion: p.L127WfsTer36 .
SNU1 Insertion: p.M103NfsTer6 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C54(0.00); C100(0.00); C63(0.00)  LDD0241  [1]
OPA-S-S-alkyne
 Probe Info  		K68(1.41); K64(1.41); K102(7.90); K101(7.90)  LDD3494  [2]
DBIA
 Probe Info  		C63(1.28)  LDD3316  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C79(1.16); C87(1.16)  LDD1093  [5]
 LDCM0246  AC128 PaTu 8988t C79(0.87); C87(0.87)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C79(0.65); C87(0.65)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C79(0.93); C87(0.93)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C79(0.88); C87(0.88)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C79(0.79); C87(0.79)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C79(0.88); C87(0.88)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C79(0.99); C87(0.99)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C79(0.92); C87(0.92)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C79(1.09); C87(1.09)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C79(0.70); C87(0.70)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C79(0.83); C87(0.83)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C79(0.97); C87(0.97)  LDD1137  [5]
 LDCM0260  AC140 PaTu 8988t C79(0.86); C87(0.86)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C79(0.82); C87(0.82)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C79(0.92); C87(0.92)  LDD1141  [5]
 LDCM0263  AC143 PaTu 8988t C79(1.26); C87(1.26)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C79(2.19); C87(2.19)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C79(1.72); C87(1.72)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C79(1.78); C87(1.78)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C79(2.00); C87(2.00)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C79(1.64); C87(1.64)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C79(1.55); C87(1.55)  LDD1148  [5]
 LDCM0271  AC150 PaTu 8988t C79(1.41); C87(1.41)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C79(1.39); C87(1.39)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C79(1.45); C87(1.45)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C79(1.42); C87(1.42)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C79(1.54); C87(1.54)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C79(1.64); C87(1.64)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C79(1.70); C87(1.70)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C79(1.54); C87(1.54)  LDD2169  [5]
 LDCM0279  AC2 PaTu 8988t C79(1.42); C87(1.42)  LDD1158  [5]
 LDCM0285  AC25 PaTu 8988t C79(1.00); C87(1.00)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C79(0.99); C87(0.99)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C79(0.86); C87(0.86)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C79(0.90); C87(0.90)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C79(1.06); C87(1.06)  LDD1168  [5]
 LDCM0290  AC3 PaTu 8988t C79(1.21); C87(1.21)  LDD1169  [5]
 LDCM0291  AC30 PaTu 8988t C79(1.21); C87(1.21)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C79(0.73); C87(0.73)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C79(0.87); C87(0.87)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C79(1.17); C87(1.17)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C79(0.91); C87(0.91)  LDD1174  [5]
 LDCM0296  AC35 PaTu 8988t C79(0.97); C87(0.97)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C79(1.15); C87(1.15)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C79(0.96); C87(0.96)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C79(1.51); C87(1.51)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C79(0.99); C87(0.99)  LDD1179  [5]
 LDCM0301  AC4 PaTu 8988t C79(1.33); C87(1.33)  LDD1180  [5]
 LDCM0302  AC40 PaTu 8988t C79(1.10); C87(1.10)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C79(1.26); C87(1.26)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C79(1.26); C87(1.26)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C79(1.30); C87(1.30)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C79(1.36); C87(1.36)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C79(1.65); C87(1.65)  LDD1186  [5]
 LDCM0308  AC46 PaTu 8988t C79(1.51); C87(1.51)  LDD1187  [5]
 LDCM0309  AC47 PaTu 8988t C79(1.12); C87(1.12)  LDD1188  [5]
 LDCM0310  AC48 PaTu 8988t C79(1.56); C87(1.56)  LDD1189  [5]
 LDCM0311  AC49 PaTu 8988t C79(0.85); C87(0.85)  LDD1190  [5]
 LDCM0312  AC5 PaTu 8988t C79(1.14); C87(1.14)  LDD1191  [5]
 LDCM0313  AC50 PaTu 8988t C79(1.15); C87(1.15)  LDD1192  [5]
 LDCM0314  AC51 PaTu 8988t C79(0.20); C87(0.20)  LDD1193  [5]
 LDCM0315  AC52 PaTu 8988t C79(0.77); C87(0.77)  LDD1194  [5]
 LDCM0316  AC53 PaTu 8988t C79(0.90); C87(0.90)  LDD1195  [5]
 LDCM0317  AC54 PaTu 8988t C79(0.92); C87(0.92)  LDD1196  [5]
 LDCM0318  AC55 PaTu 8988t C79(1.13); C87(1.13)  LDD1197  [5]
 LDCM0319  AC56 PaTu 8988t C79(1.03); C87(1.03)  LDD1198  [5]
 LDCM0320  AC57 PaTu 8988t C79(0.85); C87(0.85)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C79(1.01); C87(1.01)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C79(0.70); C87(0.70)  LDD1201  [5]
 LDCM0324  AC60 PaTu 8988t C79(0.96); C87(0.96)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C79(0.72); C87(0.72)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C79(0.79); C87(0.79)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C79(1.38); C87(1.38)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C79(1.34); C87(1.34)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C79(0.95); C87(0.95)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C79(0.81); C87(0.81)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C79(1.05); C87(1.05)  LDD1210  [5]
 LDCM0108  Chloroacetamide HeLa C250(0.00); C54(0.00)  LDD0222  [4]
 LDCM0367  CL1 PaTu 8988t C79(0.74); C87(0.74)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C79(0.62); C87(0.62)  LDD1247  [5]
 LDCM0369  CL100 PaTu 8988t C79(1.35); C87(1.35)  LDD1248  [5]
 LDCM0379  CL11 PaTu 8988t C79(0.96); C87(0.96)  LDD1258  [5]
 LDCM0382  CL112 PaTu 8988t C79(1.13); C87(1.13)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C79(1.04); C87(1.04)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C79(1.09); C87(1.09)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C79(0.85); C87(0.85)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C79(0.92); C87(0.92)  LDD1265  [5]
 LDCM0387  CL117 PaTu 8988t C79(1.20); C87(1.20)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C79(2.34); C87(2.34)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C79(0.93); C87(0.93)  LDD1268  [5]
 LDCM0390  CL12 PaTu 8988t C79(1.24); C87(1.24)  LDD1269  [5]
 LDCM0391  CL120 PaTu 8988t C79(1.21); C87(1.21)  LDD1270  [5]
 LDCM0392  CL121 PaTu 8988t C79(1.02); C87(1.02)  LDD1271  [5]
 LDCM0393  CL122 PaTu 8988t C79(0.75); C87(0.75)  LDD1272  [5]
 LDCM0394  CL123 PaTu 8988t C79(0.55); C87(0.55)  LDD1273  [5]
 LDCM0395  CL124 PaTu 8988t C79(0.91); C87(0.91)  LDD1274  [5]
 LDCM0396  CL125 PaTu 8988t C79(0.86); C87(0.86)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C79(0.65); C87(0.65)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C79(0.79); C87(0.79)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C79(0.95); C87(0.95)  LDD1278  [5]
 LDCM0400  CL13 PaTu 8988t C79(0.81); C87(0.81)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C79(1.12); C87(1.12)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C79(0.86); C87(0.86)  LDD1281  [5]
 LDCM0407  CL2 PaTu 8988t C79(0.84); C87(0.84)  LDD1286  [5]
 LDCM0418  CL3 PaTu 8988t C79(1.11); C87(1.11)  LDD1297  [5]
 LDCM0429  CL4 PaTu 8988t C79(1.23); C87(1.23)  LDD1308  [5]
 LDCM0440  CL5 PaTu 8988t C79(0.90); C87(0.90)  LDD1319  [5]
 LDCM0451  CL6 PaTu 8988t C79(0.96); C87(0.96)  LDD1330  [5]
 LDCM0462  CL7 PaTu 8988t C79(0.94); C87(0.94)  LDD1341  [5]
 LDCM0469  CL76 PaTu 8988t C79(1.64); C87(1.64)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C79(1.62); C87(1.62)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C79(1.77); C87(1.77)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C79(1.87); C87(1.87)  LDD1351  [5]
 LDCM0473  CL8 PaTu 8988t C79(0.76); C87(0.76)  LDD1352  [5]
 LDCM0474  CL80 PaTu 8988t C79(2.40); C87(2.40)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C79(1.78); C87(1.78)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C79(2.13); C87(2.13)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C79(2.10); C87(2.10)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C79(1.53); C87(1.53)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C79(2.68); C87(2.68)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C79(1.63); C87(1.63)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C79(2.22); C87(2.22)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C79(1.82); C87(1.82)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C79(1.34); C87(1.34)  LDD1362  [5]
 LDCM0484  CL9 PaTu 8988t C79(0.96); C87(0.96)  LDD1363  [5]
 LDCM0485  CL90 PaTu 8988t C79(2.12); C87(2.12)  LDD1364  [5]
 LDCM0486  CL91 PaTu 8988t C79(1.01); C87(1.01)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C79(1.11); C87(1.11)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C79(1.03); C87(1.03)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C79(0.99); C87(0.99)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C79(1.76); C87(1.76)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C79(1.37); C87(1.37)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C79(1.37); C87(1.37)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C79(1.49); C87(1.49)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C79(1.17); C87(1.17)  LDD1373  [5]
 LDCM0022  KB02 A2780 C54(1.95)  LDD2254  [3]
 LDCM0023  KB03 A2780 C54(2.51)  LDD2671  [3]
 LDCM0024  KB05 MEL167 C63(1.28)  LDD3316  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Coagulation Factor Viia Recombinant Human BiotechDrug DB00036
Dalteparin Small molecular drug DB06779
Andexanet Alfa . DB14562
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pf-06741086 Antibody D19OMU
Tifacogin Small molecular drug D0B7VK
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bax-499 . D0X4ZV
Nn-7415 . D0U0XL

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.