Details of the Target

General Information of Target

Target ID LDTP02324
Target Name Homeobox protein Hox-C4 (HOXC4)
Gene Name HOXC4
Gene ID 3221
Synonyms
HOX3E; Homeobox protein Hox-C4; Homeobox protein CP19; Homeobox protein Hox-3E
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRP
SYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQP
APDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRY
LTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATP
GTSEDHSQSATPPEQQRAEDITRL
Target Bioclass
Transcription factor
Family
Antp homeobox family, Deformed subfamily
Subcellular location
Nucleus
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Uniprot ID
P09017
Ensemble ID
ENST00000303406.4
HGNC ID
HGNC:5126

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C194(2.38)  LDD3433  [1]
N1
 Probe Info  		S192(0.00); S196(0.00)  LDD0245  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C69(1.04)  LDD1508  [5]
 LDCM0237  AC12 HEK-293T C69(1.13)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C69(1.01)  LDD1512  [5]
 LDCM0277  AC18 HEK-293T C69(1.00)  LDD1516  [5]
 LDCM0279  AC2 HEK-293T C69(1.23)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C69(1.04)  LDD1519  [5]
 LDCM0282  AC22 HEK-293T C69(1.05)  LDD1521  [5]
 LDCM0284  AC24 HEK-293T C69(0.90)  LDD1523  [5]
 LDCM0286  AC26 HEK-293T C69(1.30)  LDD1525  [5]
 LDCM0288  AC28 HEK-293T C69(1.04)  LDD1527  [5]
 LDCM0291  AC30 HEK-293T C69(1.25)  LDD1530  [5]
 LDCM0293  AC32 HEK-293T C69(0.91)  LDD1532  [5]
 LDCM0295  AC34 HEK-293T C69(1.02)  LDD1534  [5]
 LDCM0297  AC36 HEK-293T C69(0.83)  LDD1536  [5]
 LDCM0299  AC38 HEK-293T C69(1.17)  LDD1538  [5]
 LDCM0301  AC4 HEK-293T C69(0.75)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C69(0.66)  LDD1541  [5]
 LDCM0304  AC42 HEK-293T C69(1.20)  LDD1543  [5]
 LDCM0306  AC44 HEK-293T C69(0.83)  LDD1545  [5]
 LDCM0308  AC46 HEK-293T C69(1.12)  LDD1547  [5]
 LDCM0310  AC48 HEK-293T C69(1.09)  LDD1549  [5]
 LDCM0313  AC50 HEK-293T C69(1.73)  LDD1552  [5]
 LDCM0315  AC52 HEK-293T C69(1.12)  LDD1554  [5]
 LDCM0317  AC54 HEK-293T C69(1.31)  LDD1556  [5]
 LDCM0319  AC56 HEK-293T C69(0.71)  LDD1558  [5]
 LDCM0321  AC58 HEK-293T C69(0.98)  LDD1560  [5]
 LDCM0323  AC6 HEK-293T C69(1.58)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C69(0.90)  LDD1563  [5]
 LDCM0326  AC62 HEK-293T C69(1.35)  LDD1565  [5]
 LDCM0328  AC64 HEK-293T C69(0.71)  LDD1567  [5]
 LDCM0345  AC8 HEK-293T C69(1.03)  LDD1569  [5]
 LDCM0275  AKOS034007705 HEK-293T C69(0.72)  LDD1514  [5]
 LDCM0368  CL10 HEK-293T C69(1.29)  LDD1572  [5]
 LDCM0390  CL12 HEK-293T C69(0.71)  LDD1594  [5]
 LDCM0405  CL18 HEK-293T C69(1.66)  LDD1609  [5]
 LDCM0408  CL20 HEK-293T C69(0.97)  LDD1612  [5]
 LDCM0410  CL22 HEK-293T C69(1.27)  LDD1614  [5]
 LDCM0412  CL24 HEK-293T C69(0.61)  LDD1616  [5]
 LDCM0419  CL30 HEK-293T C69(1.40)  LDD1623  [5]
 LDCM0421  CL32 HEK-293T C69(0.84)  LDD1625  [5]
 LDCM0423  CL34 HEK-293T C69(1.02)  LDD1627  [5]
 LDCM0425  CL36 HEK-293T C69(0.61)  LDD1629  [5]
 LDCM0432  CL42 HEK-293T C69(1.13)  LDD1636  [5]
 LDCM0434  CL44 HEK-293T C69(0.83)  LDD1638  [5]
 LDCM0436  CL46 HEK-293T C69(1.21)  LDD1640  [5]
 LDCM0438  CL48 HEK-293T C69(0.54)  LDD1642  [5]
 LDCM0445  CL54 HEK-293T C69(1.11)  LDD1648  [5]
 LDCM0447  CL56 HEK-293T C69(1.02)  LDD1650  [5]
 LDCM0449  CL58 HEK-293T C69(1.14)  LDD1652  [5]
 LDCM0451  CL6 HEK-293T C69(1.06)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C69(0.65)  LDD1655  [5]
 LDCM0458  CL66 HEK-293T C69(0.91)  LDD1661  [5]
 LDCM0460  CL68 HEK-293T C69(0.99)  LDD1663  [5]
 LDCM0463  CL70 HEK-293T C69(1.13)  LDD1666  [5]
 LDCM0465  CL72 HEK-293T C69(0.97)  LDD1668  [5]
 LDCM0471  CL78 HEK-293T C69(0.87)  LDD1674  [5]
 LDCM0473  CL8 HEK-293T C69(1.07)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C69(0.87)  LDD1677  [5]
 LDCM0476  CL82 HEK-293T C69(1.02)  LDD1679  [5]
 LDCM0478  CL84 HEK-293T C69(0.60)  LDD1681  [5]
 LDCM0485  CL90 HEK-293T C69(0.99)  LDD1688  [5]
 LDCM0487  CL92 HEK-293T C69(1.06)  LDD1690  [5]
 LDCM0489  CL94 HEK-293T C69(1.31)  LDD1692  [5]
 LDCM0491  CL96 HEK-293T C69(0.58)  LDD1694  [5]
 LDCM0022  KB02 Kelly C194(1.23)  LDD2417  [1]
 LDCM0023  KB03 Kelly C194(1.59)  LDD2834  [1]
 LDCM0024  KB05 SK-N-AS C194(2.38)  LDD3433  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase NSD3 (NSD3) Histone-lysine methyltransferase family Q9BZ95
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Peptidyl-prolyl cis-trans isomerase B (PPIB) Cyclophilin-type PPIase family P23284
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
Dual specificity protein kinase CLK3 (CLK3) CMGC Ser/Thr protein kinase family P49761
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Huntingtin (HTT) Huntingtin family P42858
Alpha-synuclein (SNCA) Synuclein family P37840
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Progranulin (GRN) Granulin family P28799
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Alpha-2-macroglobulin (A2M) Protease inhibitor I39 (alpha-2-macroglobulin) family P01023
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) UPF0400 (RTT103) family Q9NQG5
Cytoplasmic protein NCK2 (NCK2) . O43639
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402