Details of the Target

General Information of Target

Target ID LDTP01595
Target Name Membrane protein BRI3 (BRI3)
Gene Name BRI3
Gene ID 25798
Synonyms
Membrane protein BRI3; Brain protein I3; pRGR2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPAAPPPPPYPYLVTGIPTHHPRVYNIH
SRTVTRYPANSIVVVGGCPVCRVGVLEDCFTFLGIFLAIILFPFGFICCFALRKRRCPNC
GATFA
Target Bioclass
Other
Family
BRI3 family
Subcellular location
Cytoplasm; Lysosome membrane; Cytoplasm, perinuclear region
Function Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver.
Uniprot ID
O95415
Ensemble ID
ENST00000297290.4
HGNC ID
HGNC:1109

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.F110V .
NCIH1703 SNV: p.P38L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y57(6.13)  LDD0260  [1]
DBIA
 Probe Info  		C78(2.52); C81(2.52)  LDD0080  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C78(1.10)  LDD1507  [3]
 LDCM0215  AC10 PaTu 8988t C78(1.25); C81(1.25)  LDD1094  [2]
 LDCM0226  AC11 PaTu 8988t C78(1.01); C81(1.01)  LDD1105  [2]
 LDCM0230  AC113 PaTu 8988t C78(0.99); C81(0.99)  LDD1109  [2]
 LDCM0231  AC114 PaTu 8988t C78(1.15); C81(1.15)  LDD1110  [2]
 LDCM0232  AC115 PaTu 8988t C78(0.85); C81(0.85)  LDD1111  [2]
 LDCM0233  AC116 PaTu 8988t C78(1.14); C81(1.14)  LDD1112  [2]
 LDCM0234  AC117 PaTu 8988t C78(0.89); C81(0.89)  LDD1113  [2]
 LDCM0235  AC118 PaTu 8988t C78(1.03); C81(1.03)  LDD1114  [2]
 LDCM0236  AC119 PaTu 8988t C78(1.23); C81(1.23)  LDD1115  [2]
 LDCM0237  AC12 PaTu 8988t C78(1.08); C81(1.08)  LDD1116  [2]
 LDCM0238  AC120 PaTu 8988t C78(1.03); C81(1.03)  LDD1117  [2]
 LDCM0239  AC121 PaTu 8988t C78(1.24); C81(1.24)  LDD1118  [2]
 LDCM0240  AC122 PaTu 8988t C78(0.77); C81(0.77)  LDD1119  [2]
 LDCM0241  AC123 PaTu 8988t C78(1.13); C81(1.13)  LDD1120  [2]
 LDCM0242  AC124 PaTu 8988t C78(1.07); C81(1.07)  LDD1121  [2]
 LDCM0243  AC125 PaTu 8988t C78(1.04); C81(1.04)  LDD1122  [2]
 LDCM0244  AC126 PaTu 8988t C78(1.02); C81(1.02)  LDD1123  [2]
 LDCM0245  AC127 PaTu 8988t C78(1.00); C81(1.00)  LDD1124  [2]
 LDCM0259  AC14 PaTu 8988t C78(0.95); C81(0.95)  LDD1138  [2]
 LDCM0270  AC15 PaTu 8988t C78(1.13); C81(1.13)  LDD1149  [2]
 LDCM0276  AC17 PaTu 8988t C78(1.09); C81(1.09)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C78(0.91); C81(0.91)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C78(1.65); C81(1.65)  LDD1157  [2]
 LDCM0280  AC20 PaTu 8988t C78(1.04); C81(1.04)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C78(1.24); C81(1.24)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C78(0.78); C81(0.78)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C78(1.21); C81(1.21)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C78(2.01); C81(2.01)  LDD1163  [2]
 LDCM0285  AC25 PaTu 8988t C78(0.79); C81(0.79)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C78(0.93); C81(0.93)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C78(1.23); C81(1.23)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C78(1.60); C81(1.60)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C78(1.17); C81(1.17)  LDD1168  [2]
 LDCM0291  AC30 PaTu 8988t C78(1.11); C81(1.11)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C78(1.24); C81(1.24)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C78(1.50); C81(1.50)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C78(1.19); C81(1.19)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C78(1.23); C81(1.23)  LDD1174  [2]
 LDCM0296  AC35 PaTu 8988t C78(1.31); C81(1.31)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C78(1.30); C81(1.30)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C78(0.99); C81(0.99)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C78(1.14); C81(1.14)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C78(1.16); C81(1.16)  LDD1179  [2]
 LDCM0302  AC40 PaTu 8988t C78(1.13); C81(1.13)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C78(1.24); C81(1.24)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C78(1.12); C81(1.12)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C78(1.07); C81(1.07)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C78(1.43); C81(1.43)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C78(1.34); C81(1.34)  LDD1186  [2]
 LDCM0308  AC46 HEK-293T C81(1.10)  LDD1547  [3]
 LDCM0311  AC49 HEK-293T C78(1.09)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C81(0.99)  LDD1551  [3]
 LDCM0316  AC53 HEK-293T C81(0.94)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C81(0.99)  LDD1556  [3]
 LDCM0320  AC57 HEK-293T C78(0.76)  LDD1559  [3]
 LDCM0323  AC6 PaTu 8988t C78(1.16); C81(1.16)  LDD1202  [2]
 LDCM0325  AC61 HEK-293T C81(0.90)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C81(0.94)  LDD1565  [3]
 LDCM0334  AC7 PaTu 8988t C78(0.91); C81(0.91)  LDD1213  [2]
 LDCM0345  AC8 PaTu 8988t C78(0.91); C81(0.91)  LDD1224  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C78(0.95); C81(0.95)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C78(1.08); C81(1.08)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C78(1.12); C81(1.12)  LDD1154  [2]
 LDCM0368  CL10 HEK-293T C81(1.39)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C78(0.66)  LDD1573  [3]
 LDCM0370  CL101 PaTu 8988t C78(1.00); C81(1.00)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C78(1.22); C81(1.22)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C78(1.04); C81(1.04)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C78(0.96); C81(0.96)  LDD1252  [2]
 LDCM0374  CL105 PaTu 8988t C78(1.19); C81(1.19)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C78(0.86); C81(0.86)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C78(1.09); C81(1.09)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C78(1.75); C81(1.75)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C78(1.07); C81(1.07)  LDD1257  [2]
 LDCM0380  CL110 PaTu 8988t C78(1.53); C81(1.53)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C78(1.12); C81(1.12)  LDD1260  [2]
 LDCM0382  CL112 PaTu 8988t C78(1.24); C81(1.24)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C78(1.23); C81(1.23)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C78(1.20); C81(1.20)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C78(1.19); C81(1.19)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C78(1.42); C81(1.42)  LDD1265  [2]
 LDCM0387  CL117 PaTu 8988t C78(1.18); C81(1.18)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C78(1.11); C81(1.11)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C78(1.17); C81(1.17)  LDD1268  [2]
 LDCM0391  CL120 PaTu 8988t C78(1.06); C81(1.06)  LDD1270  [2]
 LDCM0395  CL124 HEK-293T C78(0.77)  LDD1599  [3]
 LDCM0399  CL128 HEK-293T C78(0.75)  LDD1603  [3]
 LDCM0403  CL16 HEK-293T C78(0.76)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C78(0.96)  LDD1608  [3]
 LDCM0409  CL21 HEK-293T C81(1.23)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C81(1.04)  LDD1614  [3]
 LDCM0416  CL28 HEK-293T C78(0.82)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C78(0.92)  LDD1621  [3]
 LDCM0422  CL33 HEK-293T C81(1.21)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C81(1.24)  LDD1627  [3]
 LDCM0429  CL4 HEK-293T C78(0.76)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C78(0.86)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C78(1.23)  LDD1635  [3]
 LDCM0435  CL45 HEK-293T C81(1.08)  LDD1639  [3]
 LDCM0436  CL46 PaTu 8988t C78(0.87); C81(0.87)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C78(0.83); C81(0.83)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C78(1.04); C81(1.04)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C78(1.06); C81(1.06)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C78(0.96)  LDD1644  [3]
 LDCM0441  CL50 PaTu 8988t C78(1.38); C81(1.38)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C78(1.23); C81(1.23)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C78(1.09); C81(1.09)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C78(1.27); C81(1.27)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C78(1.01); C81(1.01)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C78(0.86); C81(0.86)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C78(1.02); C81(1.02)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C78(1.08); C81(1.08)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C78(0.97); C81(0.97)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C78(0.88); C81(0.88)  LDD1329  [2]
 LDCM0452  CL60 PaTu 8988t C78(1.11); C81(1.11)  LDD1331  [2]
 LDCM0456  CL64 HEK-293T C78(0.88)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C78(1.01)  LDD1660  [3]
 LDCM0461  CL69 HEK-293T C81(1.08)  LDD1664  [3]
 LDCM0463  CL70 HEK-293T C81(1.23)  LDD1666  [3]
 LDCM0469  CL76 HEK-293T C78(0.73)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C78(1.14)  LDD1673  [3]
 LDCM0475  CL81 HEK-293T C81(1.19)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C81(1.01)  LDD1679  [3]
 LDCM0482  CL88 HEK-293T C78(0.78)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C78(1.42)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C81(1.01)  LDD1687  [3]
 LDCM0488  CL93 HEK-293T C81(1.20)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C81(1.27)  LDD1692  [3]
 LDCM0022  KB02 HCT 116 C78(2.52); C81(2.52)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C78(3.28); C81(3.28)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C78(2.96); C81(2.96)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT1) Glycosyltransferase 13 family P26572
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon-induced transmembrane protein 3 (IFITM3) CD225/Dispanin family Q01628
BRI3-binding protein (BRI3BP) . Q8WY22
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MAL-like protein (MALL) MAL family Q13021

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402