Details of the Target

General Information of Target

Target ID LDTP01593
Target Name Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B)
Gene Name TNFRSF6B
Gene ID 8771
Synonyms
DCR3; TR6; Tumor necrosis factor receptor superfamily member 6B; Decoy receptor 3; DcR3; Decoy receptor for Fas ligand; M68
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETGERLVCAQCPPGTFVQR
PCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFF
AHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLA
LNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPE
GWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH
Target Bioclass
Cytokine and receptor
Subcellular location
Secreted
Function Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
Uniprot ID
O95407
Ensemble ID
ENST00000369996.3
HGNC ID
HGNC:11921

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C49(1.18); C52(1.18); C62(1.18)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C211(0.92); C70(1.08); C73(1.08)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C211(0.74); C70(1.11); C73(1.11)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C211(0.68); C70(1.10); C73(1.10)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C211(1.08); C70(1.29); C73(1.29)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C211(0.84); C70(0.85); C73(0.85)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C211(1.16)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C211(1.14)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C211(1.50)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C211(1.25)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C211(1.05)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C211(1.12)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C211(1.05)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C211(1.15)  LDD0601  [1]
 LDCM0308  AC46 HCT 116 C211(1.00)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C211(1.01)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C211(1.06)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C211(1.00)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C211(1.07)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C211(0.68)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C211(0.50)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C211(0.59)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C211(0.45)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C211(0.47)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C211(0.64)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C211(1.07)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C211(0.74)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C211(0.74)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C211(1.00); C70(1.07); C73(1.07)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C211(0.89)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C211(0.82)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C211(0.80)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C211(1.08)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C211(0.81)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C211(0.65)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C211(0.58)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C211(0.65)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C70(1.66); C73(1.66)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C70(1.31); C73(1.31)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C211(0.89); C70(1.00); C73(1.00)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C70(1.85); C73(1.85)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C70(1.68); C73(1.68)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C70(1.25); C73(1.25)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C70(1.57); C73(1.57)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C70(1.53); C73(1.53)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C70(1.95); C73(1.95)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C70(2.18); C73(2.18)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C70(1.36); C73(1.36)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C70(1.53); C73(1.53)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C70(1.12); C73(1.12)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C70(1.06); C73(1.06); C211(1.12)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C70(1.85); C73(1.85)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C70(1.36); C73(1.36)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C70(2.12); C73(2.12)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C211(0.80); C70(0.95); C73(0.95)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C70(0.91); C73(0.91); C211(1.19)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C211(0.98); C70(1.27); C73(1.27)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C211(0.83); C70(1.01); C73(1.01)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C211(0.81); C70(1.09); C73(1.09)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C211(0.60); C70(1.04); C73(1.04)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C211(0.59); C70(1.06); C73(1.06)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C211(1.09); C70(1.17); C73(1.17)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C211(0.82); C70(1.19); C73(1.19)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C211(0.80); C70(1.09); C73(1.09)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C211(0.74); C70(1.19); C73(1.19)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C211(0.96); C70(1.43); C73(1.43)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C211(0.84); C70(1.21); C73(1.21)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C211(1.10); C70(1.37); C73(1.37)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C211(1.24); C70(1.51); C73(1.51)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C211(0.88); C70(1.28); C73(1.28)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C211(0.82); C70(1.13); C73(1.13)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C211(0.91); C70(1.13); C73(1.13)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C49(1.18); C52(1.18); C62(1.18)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C211(0.87); C70(0.96); C73(0.96)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C70(0.93); C73(0.93); C211(1.20)  LDD0685  [1]
 LDCM0370  CL101 HCT 116 C211(1.05); C70(1.34); C73(1.34)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C211(0.96); C70(1.24); C73(1.24)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C211(0.90); C70(1.66); C73(1.66)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C211(0.68); C70(1.33); C73(1.33)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C211(1.04)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C211(1.13)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C211(1.10)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C211(1.10)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C211(1.13)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C70(0.89); C73(0.89); C211(1.17)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C211(1.43)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C211(1.07)  LDD0698  [1]
 LDCM0390  CL12 HCT 116 C211(0.88); C70(1.07); C73(1.07)  LDD0707  [1]
 LDCM0392  CL121 HCT 116 C211(0.82)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C211(0.83)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C211(1.04)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C211(1.26)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C211(2.51)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C211(1.24)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C211(1.16)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C211(1.41)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C70(0.92); C73(0.92); C211(1.74)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C70(0.93); C73(0.93); C211(1.13)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C211(0.88); C70(0.91); C73(0.91)  LDD0719  [1]
 LDCM0407  CL2 HCT 116 C211(0.90); C70(0.97); C73(0.97)  LDD0724  [1]
 LDCM0418  CL3 HCT 116 C211(1.02); C70(0.97); C73(0.97)  LDD0735  [1]
 LDCM0429  CL4 HCT 116 C211(0.93); C70(0.87); C73(0.87)  LDD0746  [1]
 LDCM0440  CL5 HCT 116 C211(0.73); C70(0.92); C73(0.92)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C211(1.51); C70(1.07); C73(1.07)  LDD0768  [1]
 LDCM0462  CL7 HCT 116 C211(0.97); C70(1.06); C73(1.06)  LDD0779  [1]
 LDCM0469  CL76 HCT 116 C211(1.15)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C211(1.16)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C211(1.14)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C211(0.80)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C211(1.33); C70(0.77); C73(0.77)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C211(0.77)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C211(1.00)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C211(0.72)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C211(0.56)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C211(1.04)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C211(0.78)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C211(0.59)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C211(0.48)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C211(0.62)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C211(0.56)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C211(0.96); C70(0.96); C73(0.96)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C211(0.48)  LDD0802  [1]
 LDCM0022  KB02 BxPC-3 C211(2.84)  LDD2280  [2]
 LDCM0023  KB03 BxPC-3 C211(6.12)  LDD2697  [2]
 LDCM0024  KB05 NUGC-3 C211(1.73)  LDD3367  [2]
 LDCM0021  THZ1 HCT 116 C91(1.08); C95(1.08)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 14 (TNFSF14) Tumor necrosis factor family O43557
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840