Details of the Target

General Information of Target

Target ID LDTP01521
Target Name Chondroitin sulfate proteoglycan 5 (CSPG5)
Gene Name CSPG5
Gene ID 10675
Synonyms
CALEB; NGC; Chondroitin sulfate proteoglycan 5; Acidic leucine-rich EGF-like domain-containing brain protein; Neuroglycan C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRAGGGGPGRGPPPLLLFLGAALVLASGAVPAREAGSAVEAEELVKGSPAWEPPANDTR
EEAGPPAAGEDEASWTAPGGELAGPEEVLQESAAVTGTAWLEADSPGLGGVTAEAGSGDA
QALPATLQAPHEVLGQSIMPPAIPEATEASGPPSPTPGDKLSPASELPKESPLEVWLNLG
GSTPDPQGPELTYPFQGTLEPQPASDIIDIDYFEGLDGEGRGADLGSFPGSPGTSENHPD
TEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLDEEEEEEEDDKDAVGGGDLEDENEL
LVPTGKPGLGPGTGQPTSRWHAVPPQHTLGSVPGSSIALRPRPGEPGRDLASSENGTECR
SGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQ
VMCVAVGSAALVLLLLFMMTVFFAKKLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIA
EGSHPNVRKLCNTPRTSSPHARALAHYDNVICQDDPSAPHKIQEVLKSCLKEEESFNIQN
SMSPKLEGGKGDQADLDVNCLQNNLT
Target Bioclass
Other
Subcellular location
Cell membrane
Function May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
Uniprot ID
O95196
Ensemble ID
ENST00000264723.9
HGNC ID
HGNC:2467

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C512(1.13)  LDD1492  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C399(1.08)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C399(1.20); C512(1.14)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C399(1.04)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C560(1.27); C399(1.07)  LDD1510  [1]
 LDCM0276  AC17 HEK-293T C399(1.16)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C399(1.07); C512(1.17)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C399(1.60)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C399(1.05); C512(0.99)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C560(1.17); C399(1.13)  LDD1519  [1]
 LDCM0284  AC24 HEK-293T C399(1.09)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C399(1.22)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C399(1.15); C512(1.00)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C399(1.03)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C560(0.99); C399(1.09)  LDD1527  [1]
 LDCM0290  AC3 HEK-293T C399(0.99)  LDD1529  [1]
 LDCM0293  AC32 HEK-293T C399(1.08)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C399(1.04)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C399(1.11); C512(1.15)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C399(1.05)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C560(1.25); C399(1.08)  LDD1536  [1]
 LDCM0301  AC4 HEK-293T C560(2.14); C399(1.04)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C399(1.05)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C399(1.18)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C399(1.13); C512(1.22)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C399(1.06)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C560(1.35); C399(1.10)  LDD1545  [1]
 LDCM0310  AC48 HEK-293T C399(1.00)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C399(1.22)  LDD1550  [1]
 LDCM0313  AC50 HEK-293T C399(1.19); C512(1.03)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C399(1.04)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C560(0.96); C399(1.06)  LDD1554  [1]
 LDCM0319  AC56 HEK-293T C399(1.08)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C399(1.07)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C399(1.18); C512(1.16)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C399(0.96)  LDD1561  [1]
 LDCM0324  AC60 HEK-293T C560(1.07); C399(1.05)  LDD1563  [1]
 LDCM0328  AC64 HEK-293T C399(1.04)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C399(0.95)  LDD1569  [1]
 LDCM0356  AKOS034007680 HEK-293T C399(1.21)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C399(1.07)  LDD1514  [1]
 LDCM0369  CL100 HEK-293T C399(1.02)  LDD1573  [1]
 LDCM0372  CL103 HEK-293T C560(1.33)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C399(1.08)  LDD1577  [1]
 LDCM0376  CL107 HEK-293T C560(1.11)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C399(1.19)  LDD1581  [1]
 LDCM0381  CL111 HEK-293T C560(0.79)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C399(1.13)  LDD1586  [1]
 LDCM0385  CL115 HEK-293T C560(1.14)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C399(1.03)  LDD1590  [1]
 LDCM0389  CL119 HEK-293T C560(0.93)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C399(1.23)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C399(1.06)  LDD1595  [1]
 LDCM0394  CL123 HEK-293T C560(1.00)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C399(1.27)  LDD1599  [1]
 LDCM0398  CL127 HEK-293T C560(0.96)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C399(0.96)  LDD1603  [1]
 LDCM0402  CL15 HEK-293T C560(0.72)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C399(1.02)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C399(1.50)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C399(1.21); C512(1.37)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C399(1.22)  LDD1610  [1]
 LDCM0408  CL20 HEK-293T C560(0.79); C399(1.15)  LDD1612  [1]
 LDCM0412  CL24 HEK-293T C399(1.14)  LDD1616  [1]
 LDCM0415  CL27 HEK-293T C560(0.92)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C399(1.11)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C399(1.12)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C560(0.98)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C399(1.10); C512(1.16)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C399(1.18)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C560(0.83); C399(1.18)  LDD1625  [1]
 LDCM0425  CL36 HEK-293T C399(1.29)  LDD1629  [1]
 LDCM0428  CL39 HEK-293T C560(1.39)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C399(1.02)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C399(1.01)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C399(1.21)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C399(1.05); C512(1.23)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C399(1.09)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C560(0.98); C399(1.18)  LDD1638  [1]
 LDCM0438  CL48 HEK-293T C399(1.11)  LDD1642  [1]
 LDCM0440  CL5 HEK-293T C399(1.02)  LDD1644  [1]
 LDCM0443  CL52 HEK-293T C399(1.02)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C399(1.33)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C399(1.69); C512(1.19)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C399(1.19)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C560(0.77); C399(1.24)  LDD1650  [1]
 LDCM0451  CL6 HEK-293T C399(1.64); C512(1.15)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C399(1.05)  LDD1655  [1]
 LDCM0455  CL63 HEK-293T C560(0.85)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C399(1.30)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C399(1.08)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C399(1.26); C512(1.18)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C399(1.08)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C560(1.00); C399(1.20)  LDD1663  [1]
 LDCM0462  CL7 HEK-293T C399(1.23)  LDD1665  [1]
 LDCM0465  CL72 HEK-293T C399(1.14)  LDD1668  [1]
 LDCM0469  CL76 HEK-293T C399(1.03)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C399(1.48)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C399(1.13); C512(1.18)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C399(1.17)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C560(0.84); C399(2.80)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C560(0.96); C399(1.05)  LDD1677  [1]
 LDCM0478  CL84 HEK-293T C399(1.22)  LDD1681  [1]
 LDCM0481  CL87 HEK-293T C560(1.81)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C399(1.00)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C399(1.09)  LDD1686  [1]
 LDCM0485  CL90 HEK-293T C399(2.14); C512(1.22)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C399(1.10)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C560(1.00); C399(1.36)  LDD1690  [1]
 LDCM0491  CL96 HEK-293T C399(1.13)  LDD1694  [1]
 LDCM0494  CL99 HEK-293T C560(1.25)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C560(1.03)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C560(0.95)  LDD1671  [1]
 LDCM0022  KB02 HEK-293T C512(1.13)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C512(1.09)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C512(0.94)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase GET3 (GET3) ArsA ATPase family O43681

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060