Details of the Target

General Information of Target

Target ID LDTP01501
Target Name Sphingosine 1-phosphate receptor 2 (S1PR2)
Gene Name S1PR2
Gene ID 9294
Synonyms
EDG5; Sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P2; Endothelial differentiation G-protein coupled receptor 5; Sphingosine 1-phosphate receptor Edg-5; S1P receptor Edg-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL
RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
Target Type
Clinical trial
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Receptor for the chemokine-like protein FAM19A5. Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration.
TTD ID
T47888
Uniprot ID
O95136
DrugMap ID
TTVSMOH
Ensemble ID
ENST00000646641.1
HGNC ID
HGNC:3169
ChEMBL ID
CHEMBL2955

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C305(1.95)  LDD3448  [1]
IA-alkyne
 Probe Info  		C305(1.98)  LDD2187  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C305(1.00)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C305(1.26)  LDD1509  [3]
 LDCM0259  AC14 HEK-293T C305(0.84)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C305(0.86)  LDD1513  [3]
 LDCM0277  AC18 HEK-293T C305(0.93)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C305(1.28)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C305(0.90)  LDD1518  [3]
 LDCM0282  AC22 HEK-293T C305(1.03)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C305(0.86)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C305(0.93)  LDD1523  [3]
 LDCM0286  AC26 HEK-293T C305(1.00)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C305(1.04)  LDD1526  [3]
 LDCM0290  AC3 HEK-293T C305(1.15)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C305(1.08)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C305(1.09)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C305(1.03)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C305(1.00)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C305(1.22)  LDD1535  [3]
 LDCM0299  AC38 HEK-293T C305(0.88)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C305(0.96)  LDD1539  [3]
 LDCM0302  AC40 HEK-293T C305(1.00)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C305(0.94)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C305(1.18)  LDD1544  [3]
 LDCM0308  AC46 HEK-293T C305(1.09)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C305(0.96)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C305(1.15)  LDD1549  [3]
 LDCM0313  AC50 HEK-293T C305(0.88)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C305(1.16)  LDD1553  [3]
 LDCM0317  AC54 HEK-293T C305(1.00)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C305(0.87)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C305(1.04)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C305(0.97)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C305(1.09)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C305(0.96)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C305(1.06)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C305(0.95)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C305(1.13)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C305(0.96)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C305(0.90)  LDD1569  [3]
 LDCM0275  AKOS034007705 HEK-293T C305(0.91)  LDD1514  [3]
 LDCM0368  CL10 HEK-293T C305(0.88)  LDD1572  [3]
 LDCM0379  CL11 HEK-293T C305(0.66)  LDD1583  [3]
 LDCM0390  CL12 HEK-293T C305(0.63)  LDD1594  [3]
 LDCM0405  CL18 HEK-293T C305(1.24)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C305(1.30)  LDD1610  [3]
 LDCM0410  CL22 HEK-293T C305(0.60)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C305(0.57)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C305(0.58)  LDD1616  [3]
 LDCM0419  CL30 HEK-293T C305(1.16)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C305(1.23)  LDD1624  [3]
 LDCM0423  CL34 HEK-293T C305(0.56)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C305(0.56)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C305(0.60)  LDD1629  [3]
 LDCM0432  CL42 HEK-293T C305(1.10)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C305(1.02)  LDD1637  [3]
 LDCM0436  CL46 HEK-293T C305(0.65)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C305(0.60)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C305(0.69)  LDD1642  [3]
 LDCM0445  CL54 HEK-293T C305(1.39)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C305(1.14)  LDD1649  [3]
 LDCM0449  CL58 HEK-293T C305(0.69)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C305(0.62)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C305(1.39)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C305(0.64)  LDD1655  [3]
 LDCM0458  CL66 HEK-293T C305(1.10)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C305(1.13)  LDD1662  [3]
 LDCM0462  CL7 HEK-293T C305(1.20)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C305(0.62)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C305(0.68)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C305(0.68)  LDD1668  [3]
 LDCM0471  CL78 HEK-293T C305(1.12)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C305(1.12)  LDD1675  [3]
 LDCM0476  CL82 HEK-293T C305(0.67)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C305(0.81)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C305(0.73)  LDD1681  [3]
 LDCM0485  CL90 HEK-293T C305(1.49)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C305(1.12)  LDD1689  [3]
 LDCM0489  CL94 HEK-293T C305(0.76)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C305(1.48)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C305(0.97)  LDD1694  [3]
 LDCM0625  F8 Ramos C305(1.98)  LDD2187  [2]
 LDCM0573  Fragment11 Ramos C305(1.06)  LDD2190  [2]
 LDCM0575  Fragment13 Ramos C305(1.10)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C305(5.83)  LDD2193  [2]
 LDCM0580  Fragment21 Ramos C305(0.31)  LDD2195  [2]
 LDCM0578  Fragment27 Ramos C305(0.26)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C305(1.29)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C305(0.46)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C305(0.35)  LDD2200  [2]
 LDCM0468  Fragment33 Ramos C305(0.46)  LDD2202  [2]
 LDCM0610  Fragment52 Ramos C305(0.72)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C305(0.35)  LDD2205  [2]
 LDCM0022  KB02 JVM-3 C305(1.39)  LDD2411  [1]
 LDCM0023  KB03 JeKo-1 C305(2.23)  LDD2820  [1]
 LDCM0024  KB05 SU-DHL-4 C305(1.95)  LDD3448  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402