Details of the Target

General Information of Target

Target ID LDTP01500
Target Name Zinc finger protein 202 (ZNF202)
Gene Name ZNF202
Gene ID 7753
Synonyms
ZKSCAN10; Zinc finger protein 202; Zinc finger protein with KRAB and SCAN domains 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATAVEPEDQDLWEEEGILMVKLEDDFTCRPESVLQRDDPVLETSHQNFRRFRYQEAASP
REALIRLRELCHQWLRPERRTKEQILELLVLEQFLTVLPGELQSWVRGQRPESGEEAVTL
VEGLQKQPRRPRRWVTVHVHGQEVLSEETVHLGVEPESPNELQDPVQSSTPEQSPEETTQ
SPDLGAPAEQRPHQEEELQTLQESEVPVPEDPDLPAERSSGDSEMVALLTALSQGLVTFK
DVAVCFSQDQWSDLDPTQKEFYGEYVLEEDCGIVVSLSFPIPRPDEISQVREEEPWVPDI
QEPQETQEPEILSFTYTGDRSKDEEECLEQEDLSLEDIHRPVLGEPEIHQTPDWEIVFED
NPGRLNERRFGTNISQVNSFVNLRETTPVHPLLGRHHDCSVCGKSFTCNSHLVRHLRTHT
GEKPYKCMECGKSYTRSSHLARHQKVHKMNAPYKYPLNRKNLEETSPVTQAERTPSVEKP
YRCDDCGKHFRWTSDLVRHQRTHTGEKPFFCTICGKSFSQKSVLTTHQRIHLGGKPYLCG
ECGEDFSEHRRYLAHRKTHAAEELYLCSECGRCFTHSAAFAKHLRGHASVRPCRCNECGK
SFSRRDHLVRHQRTHTGEKPFTCPTCGKSFSRGYHLIRHQRTHSEKTS
Target Type
Literature-reported
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.
TTD ID
T15914
Uniprot ID
O95125
DrugMap ID
TTD9R62
Ensemble ID
ENST00000336139.8
HGNC ID
HGNC:12994

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.F239L DBIA    Probe Info 
DU145 SNV: p.G108C DBIA    Probe Info 
HCT15 SNV: p.P187S; p.T502A .
HEC1 SNV: p.A216V DBIA    Probe Info 
HEC1B SNV: p.A216V .
PF382 SNV: p.D398G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C573(1.52)  LDD3311  [1]
Acrolein
 Probe Info  		N.A.  LDD0226  [2]
HHS-465
 Probe Info  		K423(0.00); K426(0.00); Y425(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C573(0.98)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C573(1.11)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C573(1.01)  LDD1513  [4]
 LDCM0280  AC20 HEK-293T C573(0.96)  LDD1519  [4]
 LDCM0282  AC22 HEK-293T C573(0.97)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C573(1.14)  LDD1522  [4]
 LDCM0288  AC28 HEK-293T C573(0.99)  LDD1527  [4]
 LDCM0291  AC30 HEK-293T C573(1.05)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C573(1.03)  LDD1531  [4]
 LDCM0297  AC36 HEK-293T C573(0.93)  LDD1536  [4]
 LDCM0299  AC38 HEK-293T C573(1.21)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C573(1.10)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C573(0.97)  LDD1540  [4]
 LDCM0306  AC44 HEK-293T C573(1.03)  LDD1545  [4]
 LDCM0308  AC46 HEK-293T C573(1.16)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C573(1.21)  LDD1548  [4]
 LDCM0315  AC52 HEK-293T C573(1.04)  LDD1554  [4]
 LDCM0317  AC54 HEK-293T C573(1.12)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C573(1.11)  LDD1557  [4]
 LDCM0323  AC6 HEK-293T C573(0.99)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C573(0.86)  LDD1563  [4]
 LDCM0326  AC62 HEK-293T C573(1.09)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C573(1.05)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C573(1.34)  LDD1568  [4]
 LDCM0368  CL10 HEK-293T C573(1.17)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C573(0.85); C408(1.10)  LDD1573  [4]
 LDCM0372  CL103 HEK-293T C573(1.07)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C573(1.15); C408(1.02)  LDD1577  [4]
 LDCM0376  CL107 HEK-293T C573(1.06)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C573(0.99); C408(0.98)  LDD1581  [4]
 LDCM0379  CL11 HEK-293T C573(0.48)  LDD1583  [4]
 LDCM0381  CL111 HEK-293T C573(0.99)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C573(0.97); C408(1.07)  LDD1586  [4]
 LDCM0385  CL115 HEK-293T C573(1.09)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C573(1.15); C408(1.03)  LDD1590  [4]
 LDCM0389  CL119 HEK-293T C573(1.01)  LDD1593  [4]
 LDCM0391  CL120 HEK-293T C573(1.16); C408(1.07)  LDD1595  [4]
 LDCM0394  CL123 HEK-293T C573(1.06)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C573(1.06); C408(1.00)  LDD1599  [4]
 LDCM0398  CL127 HEK-293T C573(1.09)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C573(1.09); C408(1.14)  LDD1603  [4]
 LDCM0402  CL15 HEK-293T C573(1.01)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C573(1.09); C408(1.05)  LDD1607  [4]
 LDCM0408  CL20 HEK-293T C573(1.04)  LDD1612  [4]
 LDCM0410  CL22 HEK-293T C573(1.22)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C573(1.12)  LDD1615  [4]
 LDCM0415  CL27 HEK-293T C573(0.97)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C573(0.88); C408(0.96)  LDD1620  [4]
 LDCM0418  CL3 HEK-293T C573(1.09)  LDD1622  [4]
 LDCM0421  CL32 HEK-293T C573(1.07)  LDD1625  [4]
 LDCM0423  CL34 HEK-293T C573(1.11)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C573(1.18)  LDD1628  [4]
 LDCM0428  CL39 HEK-293T C573(0.99)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C573(1.03); C408(1.17)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C573(1.09); C408(1.02)  LDD1634  [4]
 LDCM0434  CL44 HEK-293T C573(0.99)  LDD1638  [4]
 LDCM0436  CL46 HEK-293T C573(1.05)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C573(1.09)  LDD1641  [4]
 LDCM0443  CL52 HEK-293T C573(1.14); C408(1.03)  LDD1646  [4]
 LDCM0447  CL56 HEK-293T C573(1.09)  LDD1650  [4]
 LDCM0449  CL58 HEK-293T C573(1.15)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C573(1.38)  LDD1653  [4]
 LDCM0455  CL63 HEK-293T C573(1.17)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C573(0.93); C408(1.10)  LDD1659  [4]
 LDCM0460  CL68 HEK-293T C573(0.88)  LDD1663  [4]
 LDCM0463  CL70 HEK-293T C573(1.16)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C573(1.23)  LDD1667  [4]
 LDCM0469  CL76 HEK-293T C573(1.03); C408(1.05)  LDD1672  [4]
 LDCM0473  CL8 HEK-293T C573(0.82)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C573(1.03)  LDD1677  [4]
 LDCM0476  CL82 HEK-293T C573(1.13)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C573(1.02)  LDD1680  [4]
 LDCM0481  CL87 HEK-293T C573(1.06)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C573(0.97); C408(1.06)  LDD1685  [4]
 LDCM0487  CL92 HEK-293T C573(0.99)  LDD1690  [4]
 LDCM0489  CL94 HEK-293T C573(1.14)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C573(1.07)  LDD1693  [4]
 LDCM0494  CL99 HEK-293T C573(0.91)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C573(0.98)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C573(0.92)  LDD1671  [4]
 LDCM0022  KB02 8305C C573(1.31)  LDD2248  [1]
 LDCM0023  KB03 8305C C573(1.76)  LDD2665  [1]
 LDCM0024  KB05 G361 C573(1.52)  LDD3311  [1]
 LDCM0109  NEM HeLa N.A.  LDD0226  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
N-alpha-acetyltransferase 11 (NAA11) Acetyltransferase family Q9BSU3
Selenide, water dikinase 1 (SEPHS1) Selenophosphate synthase 1 family P49903
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
ELL-associated factor 1 (EAF1) EAF family Q96JC9
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
MAD2L1-binding protein (MAD2L1BP) MAD2L1BP family Q15013
Colorectal mutant cancer protein (MCC) MCC family P23508
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
LIM domain transcription factor LMO4 (LMO4) . P61968

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402