Details of the Target

General Information of Target

Target ID LDTP01403
Target Name Protein JTB (JTB)
Gene Name JTB
Gene ID 10899
Synonyms
Protein JTB; Jumping translocation breakpoint protein; Prostate androgen-regulated protein; PAR protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWLVEEFVVAEEC
SPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALMEQRLFWKFEGAVVCVALIF
ACLVIIRQRQLDRKALEKVRKQIESI
Target Bioclass
Other
Family
JTB family
Subcellular location
Membrane
Function
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.
Uniprot ID
O76095
Ensemble ID
ENST00000271843.9
HGNC ID
HGNC:6201

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.G78Ter .
KYSE510 SNV: p.E137Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K94(5.20)  LDD3494  [1]
BTD
 Probe Info  		C85(0.96)  LDD2117  [2]
DBIA
 Probe Info  		C85(0.93)  LDD1492  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_5
 Probe Info  		C74(0.00); C85(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C85(0.96)  LDD2117  [2]
 LDCM0214  AC1 HEK-293T C85(1.01)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C74(1.05)  LDD1508  [3]
 LDCM0259  AC14 HEK-293T C85(1.02)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C85(0.96)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C74(0.89)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C74(1.02)  LDD1518  [3]
 LDCM0281  AC21 HEK-293T C74(0.92); C85(1.01)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C85(1.03)  LDD1521  [3]
 LDCM0284  AC24 HEK-293T C85(0.98)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C85(1.01)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C74(1.08)  LDD1525  [3]
 LDCM0289  AC29 HEK-293T C74(1.27); C85(1.04)  LDD1528  [3]
 LDCM0291  AC30 HEK-293T C85(1.04)  LDD1530  [3]
 LDCM0293  AC32 HEK-293T C85(0.96)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C85(0.99)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C74(1.03)  LDD1534  [3]
 LDCM0298  AC37 HEK-293T C74(1.12); C85(1.05)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C85(1.03)  LDD1538  [3]
 LDCM0302  AC40 HEK-293T C85(1.03)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C85(0.98)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C74(0.84)  LDD1543  [3]
 LDCM0307  AC45 HEK-293T C74(1.53); C85(1.12)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C85(1.10)  LDD1547  [3]
 LDCM0310  AC48 HEK-293T C85(1.03)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C85(1.02)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C74(1.07); C85(0.97)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C74(0.94)  LDD1552  [3]
 LDCM0316  AC53 HEK-293T C74(0.98); C85(1.06)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C85(1.05)  LDD1556  [3]
 LDCM0319  AC56 HEK-293T C85(1.00)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C85(1.08)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C74(1.10)  LDD1560  [3]
 LDCM0323  AC6 HEK-293T C85(1.09)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C74(1.27); C85(1.08)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C85(1.05)  LDD1565  [3]
 LDCM0328  AC64 HEK-293T C85(0.96)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C85(1.00)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C74(1.16); C85(1.05)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C85(0.96)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C85(1.01)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C85(1.01)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C85(1.35)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C85(1.15)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C85(1.09)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C74(1.13); C85(1.15)  LDD1575  [3]
 LDCM0373  CL104 HEK-293T C85(1.06)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C85(1.06)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C74(1.16); C85(1.01)  LDD1579  [3]
 LDCM0377  CL108 HEK-293T C85(1.04)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C85(1.05)  LDD1582  [3]
 LDCM0380  CL110 HEK-293T C74(0.92); C85(1.11)  LDD1584  [3]
 LDCM0382  CL112 HEK-293T C85(1.12)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C85(1.01)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C74(1.22); C85(1.19)  LDD1588  [3]
 LDCM0386  CL116 HEK-293T C85(1.09)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C85(1.03)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C74(1.04); C85(1.15)  LDD1592  [3]
 LDCM0390  CL12 HEK-293T C85(1.11)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C85(1.08)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C85(1.02)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C74(1.29); C85(1.10)  LDD1597  [3]
 LDCM0395  CL124 HEK-293T C85(1.11)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C85(1.03)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C74(1.17); C85(1.14)  LDD1601  [3]
 LDCM0399  CL128 HEK-293T C85(1.06)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C85(0.99)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C74(0.94); C85(0.80)  LDD1605  [3]
 LDCM0403  CL16 HEK-293T C85(1.08)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C85(1.15)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C74(0.96)  LDD1609  [3]
 LDCM0407  CL2 HEK-293T C74(1.19); C85(1.08)  LDD1611  [3]
 LDCM0409  CL21 HEK-293T C74(1.39); C85(1.29)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C85(1.20)  LDD1614  [3]
 LDCM0412  CL24 HEK-293T C85(1.10)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C85(1.00)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C74(0.89); C85(1.03)  LDD1618  [3]
 LDCM0416  CL28 HEK-293T C85(1.09)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C85(1.01)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C74(1.11)  LDD1623  [3]
 LDCM0422  CL33 HEK-293T C74(1.84); C85(1.29)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C85(1.18)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C85(1.09)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C85(0.91)  LDD1630  [3]
 LDCM0429  CL4 HEK-293T C85(1.08)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C85(1.06)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C85(0.94)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C74(1.07)  LDD1636  [3]
 LDCM0435  CL45 HEK-293T C74(1.32); C85(1.23)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C85(1.13)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C85(1.08)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C85(0.86)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C85(0.95)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C74(1.01); C85(1.20)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C85(1.14)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C85(0.99)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C74(1.07)  LDD1648  [3]
 LDCM0448  CL57 HEK-293T C74(1.03); C85(1.26)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C85(1.31)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C74(1.05)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C85(1.11)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C85(0.96)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C74(1.12); C85(1.04)  LDD1657  [3]
 LDCM0456  CL64 HEK-293T C85(1.16)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C85(1.00)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C74(0.97)  LDD1661  [3]
 LDCM0461  CL69 HEK-293T C74(1.37); C85(1.15)  LDD1664  [3]
 LDCM0463  CL70 HEK-293T C85(1.19)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C85(1.08)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C85(0.99)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C74(1.01); C85(1.02)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C85(1.03)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C85(1.12)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C74(0.87)  LDD1674  [3]
 LDCM0475  CL81 HEK-293T C74(1.52); C85(1.09)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C85(1.10)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C85(1.09)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C85(0.92)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C74(1.15); C85(1.14)  LDD1683  [3]
 LDCM0482  CL88 HEK-293T C85(1.07)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C85(0.96)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C74(1.19); C85(1.22)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C74(0.98)  LDD1688  [3]
 LDCM0488  CL93 HEK-293T C74(1.01); C85(1.13)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C85(1.08)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C85(1.05)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C85(1.12)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C74(1.27); C85(1.17)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C74(1.14); C85(0.99)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C85(0.93)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C85(1.01)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C85(0.92)  LDD1502  [3]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264