Details of the Target

General Information of Target

Target ID LDTP01331
Target Name Trafficking protein particle complex subunit 6A (TRAPPC6A)
Gene Name TRAPPC6A
Gene ID 79090
Synonyms
Trafficking protein particle complex subunit 6A; TRAPP complex subunit 6A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADTVLFEFLHTEMVAELWAHDPDPGPGGQKMSLSVLEGMGFRVGQALGERLPRETLAFR
EELDVLKFLCKDLWVAVFQKQMDSLRTNHQGTYVLQDNSFPLLLPMASGLQYLEEAPKFL
AFTCGLLRGALYTLGIESVVTASVAALPVCKFQVVIPKS
Target Bioclass
Other
Family
TRAPP small subunits family, BET3 subfamily
Subcellular location
Golgi apparatus, cis-Golgi network
Function May play a role in vesicular transport during the biogenesis of melanosomes.
Uniprot ID
O75865
Ensemble ID
ENST00000006275.8
HGNC ID
HGNC:23069

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
SKMEL28 SNV: p.G129C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C138(5.12)  LDD3338  [1]
IA-alkyne
 Probe Info  		C124(0.58)  LDD2182  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C150(1.21)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C150(1.06)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C150(1.10)  LDD1510  [4]
 LDCM0277  AC18 HEK-293T C150(1.16)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C150(0.86)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C150(1.16)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C150(1.17)  LDD1519  [4]
 LDCM0284  AC24 HEK-293T C150(0.80)  LDD1523  [4]
 LDCM0286  AC26 HEK-293T C150(1.03)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C150(1.12)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C150(1.08)  LDD1527  [4]
 LDCM0290  AC3 HEK-293T C150(1.09)  LDD1529  [4]
 LDCM0293  AC32 HEK-293T C150(0.98)  LDD1532  [4]
 LDCM0295  AC34 HEK-293T C150(1.05)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C150(1.31)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C150(1.04)  LDD1536  [4]
 LDCM0301  AC4 HEK-293T C150(1.06)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C150(0.97)  LDD1541  [4]
 LDCM0304  AC42 HEK-293T C150(1.37)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C150(1.11)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C150(1.16)  LDD1545  [4]
 LDCM0310  AC48 HEK-293T C150(1.00)  LDD1549  [4]
 LDCM0313  AC50 HEK-293T C150(1.12)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C150(1.04)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C150(1.01)  LDD1554  [4]
 LDCM0319  AC56 HEK-293T C150(1.23)  LDD1558  [4]
 LDCM0321  AC58 HEK-293T C150(1.03)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C150(1.16)  LDD1561  [4]
 LDCM0324  AC60 HEK-293T C150(1.10)  LDD1563  [4]
 LDCM0328  AC64 HEK-293T C150(1.01)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C150(0.83)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C150(1.18)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C150(1.08)  LDD1571  [4]
 LDCM0370  CL101 HEK-293T C150(1.06)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C150(1.33)  LDD1575  [4]
 LDCM0374  CL105 HEK-293T C150(0.90)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C150(1.20)  LDD1579  [4]
 LDCM0378  CL109 HEK-293T C150(0.95)  LDD1582  [4]
 LDCM0380  CL110 HEK-293T C150(1.24)  LDD1584  [4]
 LDCM0383  CL113 HEK-293T C150(1.44)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C150(1.34)  LDD1588  [4]
 LDCM0387  CL117 HEK-293T C150(1.06)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C150(1.05)  LDD1592  [4]
 LDCM0390  CL12 HEK-293T C150(1.15)  LDD1594  [4]
 LDCM0392  CL121 HEK-293T C150(1.14)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C150(1.09)  LDD1597  [4]
 LDCM0396  CL125 HEK-293T C150(1.27)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C150(1.30)  LDD1601  [4]
 LDCM0400  CL13 HEK-293T C150(0.85)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C150(1.23)  LDD1605  [4]
 LDCM0405  CL18 HEK-293T C150(1.28)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C150(1.21)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C150(1.08)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C150(1.16)  LDD1612  [4]
 LDCM0412  CL24 HEK-293T C150(1.37)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C150(0.95)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C150(1.19)  LDD1618  [4]
 LDCM0419  CL30 HEK-293T C150(1.17)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C150(1.13)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C150(1.08)  LDD1625  [4]
 LDCM0425  CL36 HEK-293T C150(1.16)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C150(1.19)  LDD1630  [4]
 LDCM0432  CL42 HEK-293T C150(1.20)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C150(1.17)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C150(1.19)  LDD1638  [4]
 LDCM0438  CL48 HEK-293T C150(1.17)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C150(0.89)  LDD1643  [4]
 LDCM0441  CL50 HEK-293T C150(0.92)  LDD1645  [4]
 LDCM0445  CL54 HEK-293T C150(1.24)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C150(1.23)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C150(1.13)  LDD1650  [4]
 LDCM0451  CL6 HEK-293T C150(1.60)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C150(0.88)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C150(1.11)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C150(1.27)  LDD1657  [4]
 LDCM0458  CL66 HEK-293T C150(1.26)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C150(1.21)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C150(1.21)  LDD1663  [4]
 LDCM0462  CL7 HEK-293T C150(1.15)  LDD1665  [4]
 LDCM0465  CL72 HEK-293T C150(1.09)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C150(0.99)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C150(1.17)  LDD1670  [4]
 LDCM0471  CL78 HEK-293T C150(1.28)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C150(1.09)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C150(1.53)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C150(1.20)  LDD1677  [4]
 LDCM0478  CL84 HEK-293T C150(1.02)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C150(1.03)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C150(1.38)  LDD1683  [4]
 LDCM0485  CL90 HEK-293T C150(1.55)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C150(1.18)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C150(1.11)  LDD1690  [4]
 LDCM0491  CL96 HEK-293T C150(2.07)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C150(1.08)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C150(1.18)  LDD1696  [4]
 LDCM0625  F8 Ramos C124(0.45)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C124(0.48)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C124(0.34)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C124(0.83)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C124(0.69)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C124(0.87)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C124(0.66)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C124(0.81)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C124(1.19)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C124(0.81)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C124(2.43)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C124(0.55)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C124(0.79)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C124(0.45)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C124(0.61)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C124(0.65)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C124(1.07)  LDD2184  [2]
 LDCM0427  Fragment51 HEK-293T C150(1.26)  LDD1631  [4]
 LDCM0610  Fragment52 Ramos C124(0.49)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C124(0.42)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C124(0.78)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C124(0.85)  LDD2188  [2]
 LDCM0022  KB02 Ramos C124(0.58)  LDD2182  [2]
 LDCM0023  KB03 Ramos C124(0.85)  LDD2183  [2]
 LDCM0024  KB05 MV4-11 C138(5.12)  LDD3338  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) . Q9GZU7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 90 homolog (ZFP90) Krueppel C2H2-type zinc-finger protein family Q8TF47
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Forkhead box protein N1 (FOXN1) . O15353
LIM/homeobox protein Lhx4 (LHX4) . Q969G2
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolae-associated protein 2 (CAVIN2) CAVIN family O95810
DNA replication complex GINS protein PSF3 (GINS3) GINS3/PSF3 family Q9BRX5
Golgin subfamily A member 6A (GOLGA6A) GOLGA6 family Q9NYA3
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Protein INCA1 (INCA1) INCA family Q0VD86
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Rab-3A-interacting protein (RAB3IP) SEC2 family Q96QF0
Splicing factor 3B subunit 5 (SF3B5) SF3B5 family Q9BWJ5
Heat shock protein beta-8 (HSPB8) Small heat shock protein (HSP20) family Q9UJY1
Trafficking protein particle complex subunit 3 (TRAPPC3) TRAPP small subunits family O43617
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
BAG family molecular chaperone regulator 4 (BAG4) . O95429
CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) . O95400
KN motif and ankyrin repeat domain-containing protein 4 (KANK4) . Q5T7N3
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
S-palmitoyl-l-cysteine . DB08342

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402