Details of the Target

General Information of Target

Target ID LDTP00955
Target Name Mitogen-activated protein kinase-binding protein 1 (MAPKBP1)
Gene Name MAPKBP1
Gene ID 23005
Synonyms
JNKBP1; KIAA0596; Mitogen-activated protein kinase-binding protein 1; JNK-binding protein 1; JNKBP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR
SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
LLLRAVERRMERKL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. Involved in JNK signaling pathway.
Uniprot ID
O60336
Ensemble ID
ENST00000456763.6
HGNC ID
HGNC:29536

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C1346(11.92)  LDD1706  [1]
DBIA
 Probe Info  		C408(1.22); C417(1.22)  LDD1094  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C408(1.22); C417(1.22)  LDD1094  [2]
 LDCM0226  AC11 PaTu 8988t C408(1.05); C417(1.05)  LDD1105  [2]
 LDCM0237  AC12 PaTu 8988t C408(1.03); C417(1.03)  LDD1116  [2]
 LDCM0259  AC14 PaTu 8988t C408(1.04); C417(1.04)  LDD1138  [2]
 LDCM0263  AC143 PaTu 8988t C408(1.58); C417(1.58)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C408(1.34); C417(1.34)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C408(1.24); C417(1.24)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C408(0.75); C417(0.75)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C408(1.59); C417(1.59)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C408(1.57); C417(1.57)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C408(1.82); C417(1.82)  LDD1148  [2]
 LDCM0270  AC15 PaTu 8988t C408(1.15); C417(1.15)  LDD1149  [2]
 LDCM0271  AC150 PaTu 8988t C408(1.48); C417(1.48)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C408(1.31); C417(1.31)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C408(1.52); C417(1.52)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C408(1.21); C417(1.21)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C408(1.31); C417(1.31)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C408(1.37); C417(1.37)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C408(1.46); C417(1.46)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C408(1.52); C417(1.52)  LDD2169  [2]
 LDCM0276  AC17 PaTu 8988t C408(0.64); C417(0.64)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C408(0.72); C417(0.72)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C408(0.64); C417(0.64)  LDD1157  [2]
 LDCM0280  AC20 PaTu 8988t C408(0.90); C417(0.90)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C408(0.85); C417(0.85)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C408(0.81); C417(0.81)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C408(0.93); C417(0.93)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C408(1.17); C417(1.17)  LDD1163  [2]
 LDCM0308  AC46 PaTu 8988t C408(0.75); C417(0.75)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C408(0.70); C417(0.70)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C408(0.48); C417(0.48)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C408(0.56); C417(0.56)  LDD1190  [2]
 LDCM0313  AC50 PaTu 8988t C408(0.57); C417(0.57)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C408(0.19); C417(0.19)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C408(0.61); C417(0.61)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C408(0.73); C417(0.73)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C408(0.69); C417(0.69)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C408(0.93); C417(0.93)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C408(0.68); C417(0.68)  LDD1198  [2]
 LDCM0323  AC6 PaTu 8988t C408(0.83); C417(0.83)  LDD1202  [2]
 LDCM0334  AC7 PaTu 8988t C408(1.03); C417(1.03)  LDD1213  [2]
 LDCM0345  AC8 PaTu 8988t C408(1.29); C417(1.29)  LDD1224  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C408(1.19); C417(1.19)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C408(1.03); C417(1.03)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C408(1.03); C417(1.03)  LDD1154  [2]
 LDCM0020  ARS-1620 HCC44 C408(0.99); C417(0.99)  LDD2171  [2]
 LDCM0367  CL1 PaTu 8988t C408(0.90); C417(0.90)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C408(0.93); C417(0.93)  LDD1247  [2]
 LDCM0370  CL101 PaTu 8988t C408(0.95); C417(0.95)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C408(1.13); C417(1.13)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C408(1.33); C417(1.33)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C408(0.92); C417(0.92)  LDD1252  [2]
 LDCM0374  CL105 PaTu 8988t C408(0.87); C417(0.87)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C408(0.62); C417(0.62)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C408(1.16); C417(1.16)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C408(0.84); C417(0.84)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C408(0.80); C417(0.80)  LDD1257  [2]
 LDCM0379  CL11 PaTu 8988t C408(0.92); C417(0.92)  LDD1258  [2]
 LDCM0380  CL110 PaTu 8988t C408(0.87); C417(0.87)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C408(1.04); C417(1.04)  LDD1260  [2]
 LDCM0390  CL12 PaTu 8988t C408(1.06); C417(1.06)  LDD1269  [2]
 LDCM0392  CL121 PaTu 8988t C408(0.57); C417(0.57)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C408(0.60); C417(0.60)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C408(0.53); C417(0.53)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C408(0.55); C417(0.55)  LDD1274  [2]
 LDCM0400  CL13 PaTu 8988t C408(0.87); C417(0.87)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C408(0.94); C417(0.94)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C408(0.73); C417(0.73)  LDD1281  [2]
 LDCM0407  CL2 PaTu 8988t C408(0.94); C417(0.94)  LDD1286  [2]
 LDCM0418  CL3 PaTu 8988t C408(1.31); C417(1.31)  LDD1297  [2]
 LDCM0429  CL4 PaTu 8988t C408(1.89); C417(1.89)  LDD1308  [2]
 LDCM0436  CL46 PaTu 8988t C408(0.87); C417(0.87)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C408(0.78); C417(0.78)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C408(0.82); C417(0.82)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C408(0.78); C417(0.78)  LDD1318  [2]
 LDCM0440  CL5 PaTu 8988t C408(0.86); C417(0.86)  LDD1319  [2]
 LDCM0441  CL50 PaTu 8988t C408(0.83); C417(0.83)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C408(0.89); C417(0.89)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C408(0.86); C417(0.86)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C408(1.15); C417(1.15)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C408(0.79); C417(0.79)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C408(0.90); C417(0.90)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C408(0.72); C417(0.72)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C408(0.73); C417(0.73)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C408(0.88); C417(0.88)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C408(0.99); C417(0.99)  LDD1329  [2]
 LDCM0451  CL6 PaTu 8988t C408(0.92); C417(0.92)  LDD1330  [2]
 LDCM0452  CL60 PaTu 8988t C408(0.88); C417(0.88)  LDD1331  [2]
 LDCM0462  CL7 PaTu 8988t C408(1.18); C417(1.18)  LDD1341  [2]
 LDCM0473  CL8 PaTu 8988t C408(1.00); C417(1.00)  LDD1352  [2]
 LDCM0484  CL9 PaTu 8988t C408(0.89); C417(0.89)  LDD1363  [2]
 LDCM0024  KB05 T cell-activated C1346(11.92)  LDD1706  [1]
 LDCM0021  THZ1 HCT 116 C408(0.99); C417(0.99)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Group 10 secretory phospholipase A2 (PLA2G10) Phospholipase A2 family O15496
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) RBR family Q9BYM8
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Protein yippee-like 5 (YPEL5) Yippee family P62699
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) . Q9GZU7
Glutaredoxin-3 (GLRX3) . O76003
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Phospholipid scramblase 3 (PLSCR3) Phospholipid scramblase family Q9NRY6
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Forkhead box protein N1 (FOXN1) . O15353
Homeobox protein MOX-2 (MEOX2) . P50222
Myogenin (MYOG) . P15173
Transcription factor 12 (TCF12) . Q99081
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cuticular Hb6 (KRT86) Intermediate filament family O43790
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Keratin-associated protein 3-2 (KRTAP3-2) KRTAP type 3 family Q9BYR7
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Keratin-associated protein 5-6 (KRTAP5-6) KRTAP type 5 family Q6L8G9
Keratin-associated protein 5-7 (KRTAP5-7) KRTAP type 5 family Q6L8G8
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Keratin-associated protein 9-4 (KRTAP9-4) KRTAP type 9 family Q9BYQ2
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Testis-expressed protein 11 (TEX11) SPO22 family Q8IYF3
Protein sprouty homolog 2 (SPRY2) Sprouty family O43597
Protein sprouty homolog 3 (SPRY3) Sprouty family O43610
Tektin-5 (TEKT5) Tektin family Q96M29
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Keratinocyte proline-rich protein (KPRP) . Q5T749
Regulator of G-protein signaling 20 (RGS20) . O76081

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019