Details of the Target

General Information of Target

Target ID LDTP00265
Target Name Forkhead box protein N3 (FOXN3)
Gene Name FOXN3
Gene ID 1112
Synonyms
C14orf116; CHES1; Forkhead box protein N3; Checkpoint suppressor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEEL
TNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFS
CLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS
QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFF
KRNGALLQDPDIDAASAMMLLNTPPEIQAGFPPGVIQNGARVLSRGLFPGVRPLPITPIG
VTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSS
SADDHYEFATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKK
RQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKG
QKEQKETTKN
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
Uniprot ID
O00409
Ensemble ID
ENST00000261302.9
HGNC ID
HGNC:1928

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C469(0.82)  LDD1508  [1]
TFBX
 Probe Info  		N.A.  LDD0027  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0151  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C469(0.82)  LDD1508  [1]
 LDCM0259  AC14 HEK-293T C469(1.08)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C469(1.14); C25(1.16)  LDD1513  [1]
 LDCM0277  AC18 HEK-293T C469(1.00)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C469(1.02)  LDD1518  [1]
 LDCM0281  AC21 HEK-293T C469(1.04)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C469(0.98)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C469(1.05); C25(0.93)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C469(0.99)  LDD1523  [1]
 LDCM0286  AC26 HEK-293T C469(0.99)  LDD1525  [1]
 LDCM0289  AC29 HEK-293T C469(1.11)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C469(1.04)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C469(0.96); C25(1.02)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C469(1.18)  LDD1532  [1]
 LDCM0295  AC34 HEK-293T C469(0.99)  LDD1534  [1]
 LDCM0298  AC37 HEK-293T C469(0.98)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C469(1.08)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C469(0.93); C25(1.16)  LDD1539  [1]
 LDCM0302  AC40 HEK-293T C469(1.04)  LDD1541  [1]
 LDCM0304  AC42 HEK-293T C469(0.97)  LDD1543  [1]
 LDCM0307  AC45 HEK-293T C469(1.18)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C469(1.01)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C469(0.95); C25(1.06)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C469(1.07)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C469(1.07)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C469(1.09)  LDD1552  [1]
 LDCM0316  AC53 HEK-293T C469(1.15)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C469(0.97)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C469(0.88); C25(1.05)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C469(1.05)  LDD1558  [1]
 LDCM0321  AC58 HEK-293T C469(0.90)  LDD1560  [1]
 LDCM0323  AC6 HEK-293T C469(0.91)  LDD1562  [1]
 LDCM0325  AC61 HEK-293T C469(1.06)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C469(1.04)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C469(1.01); C25(1.13)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C469(1.14)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C469(1.03); C25(1.10)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C469(1.05)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C469(1.06)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C469(1.14)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C469(1.07)  LDD1572  [1]
 LDCM0372  CL103 HEK-293T C469(0.91)  LDD1576  [1]
 LDCM0376  CL107 HEK-293T C469(0.63)  LDD1580  [1]
 LDCM0379  CL11 HEK-293T C469(0.99); C25(0.91)  LDD1583  [1]
 LDCM0381  CL111 HEK-293T C469(0.92)  LDD1585  [1]
 LDCM0385  CL115 HEK-293T C469(0.92)  LDD1589  [1]
 LDCM0389  CL119 HEK-293T C469(1.05)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C469(1.05)  LDD1594  [1]
 LDCM0394  CL123 HEK-293T C469(0.64)  LDD1598  [1]
 LDCM0398  CL127 HEK-293T C469(0.58)  LDD1602  [1]
 LDCM0402  CL15 HEK-293T C469(0.80)  LDD1606  [1]
 LDCM0405  CL18 HEK-293T C469(1.11)  LDD1609  [1]
 LDCM0409  CL21 HEK-293T C469(1.03)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C469(0.99)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C469(1.06); C25(1.27)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C469(1.10)  LDD1616  [1]
 LDCM0415  CL27 HEK-293T C469(0.80)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C469(1.02)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C469(1.13)  LDD1623  [1]
 LDCM0422  CL33 HEK-293T C469(1.12)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C469(0.99)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C469(1.20); C25(1.20)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C469(1.04)  LDD1629  [1]
 LDCM0428  CL39 HEK-293T C469(0.65)  LDD1632  [1]
 LDCM0432  CL42 HEK-293T C469(0.96)  LDD1636  [1]
 LDCM0435  CL45 HEK-293T C469(1.18)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C469(1.05)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C469(1.42); C25(1.02)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C469(1.15)  LDD1642  [1]
 LDCM0445  CL54 HEK-293T C469(1.00)  LDD1648  [1]
 LDCM0448  CL57 HEK-293T C469(1.22)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C469(1.00)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C469(0.96); C25(1.22)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C469(1.04)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C469(1.14)  LDD1655  [1]
 LDCM0455  CL63 HEK-293T C469(0.69)  LDD1658  [1]
 LDCM0458  CL66 HEK-293T C469(1.22)  LDD1661  [1]
 LDCM0461  CL69 HEK-293T C469(1.19)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C469(1.07)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C469(0.92); C25(1.20)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C469(1.24)  LDD1668  [1]
 LDCM0471  CL78 HEK-293T C469(0.94)  LDD1674  [1]
 LDCM0475  CL81 HEK-293T C469(1.15)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C469(1.02)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C469(1.01); C25(1.16)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C469(1.19)  LDD1681  [1]
 LDCM0481  CL87 HEK-293T C469(0.80)  LDD1684  [1]
 LDCM0484  CL9 HEK-293T C469(1.15)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C469(1.09)  LDD1688  [1]
 LDCM0488  CL93 HEK-293T C469(1.01)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C469(1.10)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C469(0.99); C25(1.22)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C469(0.95)  LDD1694  [1]
 LDCM0494  CL99 HEK-293T C469(1.20)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C469(0.98)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C469(0.99)  LDD1671  [1]
 LDCM0024  KB05 T cell-activated C469(6.34)  LDD1706  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SNW domain-containing protein 1 (SNW1) SNW family Q13573

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.