Details of the Target

General Information of Target

Target ID LDTP00227
Target Name Bone morphogenetic protein receptor type-1B (BMPR1B)
Gene Name BMPR1B
Gene ID 658
Synonyms
Bone morphogenetic protein receptor type-1B; BMP type-1B receptor; BMPR-1B; EC 2.7.11.30; CD antigen CDw293
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED
DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD
GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS
RLTALRVKKTLAKMSESQDIKL
Target Bioclass
Enzyme
Family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Subcellular location
Cell membrane
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
Uniprot ID
O00238
Ensemble ID
ENST00000264568.8
HGNC ID
HGNC:1077
ChEMBL ID
CHEMBL5476

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU1 SNV: p.F242L .
DU145 SNV: p.A229D .
HT115 SNV: p.R214C .
IGROV1 SNV: p.G268R .
MEWO SNV: p.V207M; p.E442K .
NCIH1993 SNV: p.D297E .
NCIH23 SNV: p.W474C .
ONS76 SNV: p.S394F .
SKMEL30 SNV: p.S190L .
SW756 SNV: p.S416L .
TKKK SNV: p.T245R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C473(0.99)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C473(0.99)  LDD1509  [1]
 LDCM0259  AC14 HEK-293T C95(0.99)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C462(1.11)  LDD1513  [1]
 LDCM0278  AC19 HEK-293T C473(1.05)  LDD1517  [1]
 LDCM0282  AC22 HEK-293T C95(0.96)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C462(1.07)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C462(0.98); C96(0.96)  LDD1523  [1]
 LDCM0287  AC27 HEK-293T C473(0.91)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C473(0.83)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C95(0.97)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C462(1.06)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C462(1.06); C96(1.02)  LDD1532  [1]
 LDCM0296  AC35 HEK-293T C473(0.97)  LDD1535  [1]
 LDCM0299  AC38 HEK-293T C95(1.08)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C462(1.12)  LDD1539  [1]
 LDCM0302  AC40 HEK-293T C462(0.95); C96(0.89)  LDD1541  [1]
 LDCM0305  AC43 HEK-293T C473(1.09)  LDD1544  [1]
 LDCM0308  AC46 HEK-293T C95(1.06)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C462(1.06)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C462(0.96); C96(0.92)  LDD1549  [1]
 LDCM0314  AC51 HEK-293T C473(1.00)  LDD1553  [1]
 LDCM0317  AC54 HEK-293T C95(0.96)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C462(1.09)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C462(1.04); C96(0.93)  LDD1558  [1]
 LDCM0322  AC59 HEK-293T C473(0.90)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C95(0.98)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C95(0.95)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C462(1.11)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C462(1.01); C96(0.92)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C462(1.03)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C462(0.96); C96(0.93)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C462(1.03); C96(0.95)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C95(1.03)  LDD1572  [1]
 LDCM0371  CL102 HEK-293T C462(1.02)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C462(1.27)  LDD1576  [1]
 LDCM0375  CL106 HEK-293T C462(1.04)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C462(1.05)  LDD1580  [1]
 LDCM0379  CL11 HEK-293T C462(1.28)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C462(1.01)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C462(1.14)  LDD1585  [1]
 LDCM0384  CL114 HEK-293T C462(1.15)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C462(1.32)  LDD1589  [1]
 LDCM0388  CL118 HEK-293T C462(1.03)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C462(1.12)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C462(1.08); C96(0.96)  LDD1594  [1]
 LDCM0393  CL122 HEK-293T C462(1.09)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C462(1.25)  LDD1598  [1]
 LDCM0397  CL126 HEK-293T C462(1.04)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C462(1.06)  LDD1602  [1]
 LDCM0401  CL14 HEK-293T C462(1.04)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C462(1.34)  LDD1606  [1]
 LDCM0406  CL19 HEK-293T C473(0.94)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C462(1.03)  LDD1611  [1]
 LDCM0410  CL22 HEK-293T C95(1.05)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C462(1.23)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C462(1.02); C96(1.08)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C462(1.05)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C462(1.09)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C462(1.13)  LDD1622  [1]
 LDCM0420  CL31 HEK-293T C473(1.01)  LDD1624  [1]
 LDCM0423  CL34 HEK-293T C95(1.00)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C462(1.22)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C462(1.15); C96(1.00)  LDD1629  [1]
 LDCM0428  CL39 HEK-293T C462(1.19)  LDD1632  [1]
 LDCM0433  CL43 HEK-293T C473(0.95)  LDD1637  [1]
 LDCM0436  CL46 HEK-293T C95(1.08)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C462(1.21)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C462(1.19); C96(0.96)  LDD1642  [1]
 LDCM0441  CL50 HEK-293T C462(1.20)  LDD1645  [1]
 LDCM0446  CL55 HEK-293T C473(0.95)  LDD1649  [1]
 LDCM0449  CL58 HEK-293T C95(0.99)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C462(1.22)  LDD1653  [1]
 LDCM0452  CL60 HEK-293T C462(1.19); C96(1.03)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C462(1.00)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C462(1.12)  LDD1658  [1]
 LDCM0459  CL67 HEK-293T C473(0.84)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C473(0.88)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C95(0.98)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C462(1.18)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C462(1.06); C96(0.97)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C462(1.02)  LDD1670  [1]
 LDCM0472  CL79 HEK-293T C473(0.97)  LDD1675  [1]
 LDCM0476  CL82 HEK-293T C95(1.11)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C462(1.26)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C462(1.18); C96(1.04)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C462(1.09)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C462(1.27)  LDD1684  [1]
 LDCM0486  CL91 HEK-293T C473(0.95)  LDD1689  [1]
 LDCM0489  CL94 HEK-293T C95(1.05)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C462(1.45)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C462(1.21); C96(0.77)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C462(1.01)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C462(1.15)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C462(1.17)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C462(1.20)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C462(1.04)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C473(0.99)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C473(0.95)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C473(1.00)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402