Details of the Target

General Information of Target

Target ID LDTP00062
Target Name GTP-binding protein 10 (GTPBP10)
Gene Name GTPBP10
Gene ID 85865
Synonyms
OBGH2; GTP-binding protein 10; Protein obg homolog 2; ObgH2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVHCSCVLFRKYGNFIDKLRLFTRGGSGGMGYPRLGGEGGKGGDVWVVAQNRMTLKQLKD
RYPRKRFVAGVGANSKISALKGSKGKDCEIPVPVGISVTDENGKIIGELNKENDRILVAQ
GGLGGKLLTNFLPLKGQKRIIHLDLKLIADVGLVGFPNAGKSSLLSCVSHAKPAIADYAF
TTLKPELGKIMYSDFKQISVADLPGLIEGAHMNKGMGHKFLKHIERTRQLLFVVDISGFQ
LSSHTQYRTAFETIILLTKELELYKEELQTKPALLAVNKMDLPDAQDKFHELMSQLQNPK
DFLHLFEKNMIPERTVEFQHIIPISAVTGEGIEELKNCIRKSLDEQANQENDALHKKQLL
NLWISDTMSSTEPPSKHAVTTSKMDII
Target Bioclass
Enzyme
Family
TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family
Subcellular location
Nucleus, nucleolus
Function
May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed.
Uniprot ID
A4D1E9
Ensemble ID
ENST00000222511.11
HGNC ID
HGNC:25106

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.09  LDD0402  [1]
STPyne
 Probe Info  		K18(0.46)  LDD0277  [2]
BTD
 Probe Info  		C167(0.64)  LDD2123  [3]
DBIA
 Probe Info  		C88(0.97)  LDD1492  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
NAIA_5
 Probe Info  		C167(0.00); C338(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C338(2.02)  LDD0372  [11]
 LDCM0284  AC24 HEK-293T C88(0.97)  LDD1523  [4]
 LDCM0293  AC32 HEK-293T C88(0.96)  LDD1532  [4]
 LDCM0302  AC40 HEK-293T C88(0.99)  LDD1541  [4]
 LDCM0310  AC48 HEK-293T C88(1.04)  LDD1549  [4]
 LDCM0319  AC56 HEK-293T C88(0.95)  LDD1558  [4]
 LDCM0328  AC64 HEK-293T C88(1.17)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C88(0.91)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C88(1.05)  LDD1514  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0390  CL12 HEK-293T C88(0.93)  LDD1594  [4]
 LDCM0412  CL24 HEK-293T C88(0.88)  LDD1616  [4]
 LDCM0425  CL36 HEK-293T C88(0.94)  LDD1629  [4]
 LDCM0438  CL48 HEK-293T C88(0.93)  LDD1642  [4]
 LDCM0452  CL60 HEK-293T C88(0.86)  LDD1655  [4]
 LDCM0465  CL72 HEK-293T C88(0.83)  LDD1668  [4]
 LDCM0478  CL84 HEK-293T C88(0.97)  LDD1681  [4]
 LDCM0491  CL96 HEK-293T C88(0.94)  LDD1694  [4]
 LDCM0625  F8 Ramos C338(0.51)  LDD2187  [12]
 LDCM0573  Fragment11 Ramos C338(0.59); C167(1.06)  LDD2190  [12]
 LDCM0576  Fragment14 Ramos C338(0.97); C167(0.21)  LDD2193  [12]
 LDCM0586  Fragment28 Ramos C338(0.89); C167(2.78)  LDD2198  [12]
 LDCM0566  Fragment4 Ramos C338(0.71); C167(1.07)  LDD2184  [12]
 LDCM0569  Fragment7 Ramos C338(0.56); C167(0.61)  LDD2186  [12]
 LDCM0022  KB02 HEK-293T C88(0.97)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C88(0.94)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C88(0.95)  LDD1502  [4]
 LDCM0109  NEM HeLa N.A.  LDD0225  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C167(0.64)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C167(0.80)  LDD2125  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C167(0.86)  LDD2140  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C167(1.37)  LDD2146  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578