Details of the Target

General Information of Target

Target ID LDTP00028
Target Name Solute carrier family 22 member 23 (SLC22A23)
Gene Name SLC22A23
Gene ID 63027
Synonyms
C6orf85; Solute carrier family 22 member 23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASAPLGGRAGPGGGAEIQPLPPLHPGG
GPHPSCCSAAAAPSLLLLDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFL
LDQPNFWCRGAGKGTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGG
DTPPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGL
IFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILT
LYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYW
SIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIPELEKELSRRPKKVCIVK
VVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSC
LAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAF
SIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLH
HIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPLLPHKKGEQPLLLTNAELKD
YSGLHDAAAAGDTLPEGATANGMKAM
Target Bioclass
Transporter and channel
Family
Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
Subcellular location
Membrane
Uniprot ID
A1A5C7
Ensemble ID
ENST00000380298.2
HGNC ID
HGNC:21106

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.E634K .
HCT116 SNV: p.D193G .
HT115 SNV: p.F283L .
HUPT3 SNV: p.G491W .
MOLT4 SNV: p.A605V .
RL952 SNV: p.A42T .
WM115 SNV: p.S662Ter .
WM2664 SNV: p.S662Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C223(0.96)  LDD1509  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C223(0.96)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C223(1.04)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C223(0.94)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C223(0.94)  LDD1513  [1]
 LDCM0278  AC19 HEK-293T C223(1.20)  LDD1517  [1]
 LDCM0280  AC20 HEK-293T C223(0.91)  LDD1519  [1]
 LDCM0282  AC22 HEK-293T C223(1.01)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C223(1.13)  LDD1522  [1]
 LDCM0287  AC27 HEK-293T C223(0.97)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C223(1.00)  LDD1527  [1]
 LDCM0290  AC3 HEK-293T C223(0.97)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C223(1.07)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C223(0.90)  LDD1531  [1]
 LDCM0296  AC35 HEK-293T C223(1.08)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C223(1.00)  LDD1536  [1]
 LDCM0299  AC38 HEK-293T C223(1.03)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C223(1.18)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C223(1.00)  LDD1540  [1]
 LDCM0305  AC43 HEK-293T C223(1.05)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C223(1.07)  LDD1545  [1]
 LDCM0308  AC46 HEK-293T C223(0.99)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C223(0.80)  LDD1548  [1]
 LDCM0314  AC51 HEK-293T C223(1.03)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C223(1.05)  LDD1554  [1]
 LDCM0317  AC54 HEK-293T C223(1.10)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C223(1.03)  LDD1557  [1]
 LDCM0322  AC59 HEK-293T C223(1.03)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C223(1.04)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C223(1.04)  LDD1563  [1]
 LDCM0326  AC62 HEK-293T C223(1.07)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C223(1.03)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C223(0.97)  LDD1568  [1]
 LDCM0368  CL10 HEK-293T C223(1.72)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C223(1.03)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C223(1.01)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C223(0.99)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C223(0.96)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C223(1.03)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C223(0.99)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C223(0.98)  LDD1581  [1]
 LDCM0379  CL11 HEK-293T C223(1.13)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C223(1.02)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C223(1.18)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C223(0.94)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C223(1.15)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C223(1.01)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C223(0.95)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C223(0.96)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C223(1.02)  LDD1593  [1]
 LDCM0391  CL120 HEK-293T C223(0.88)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C223(1.05)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C223(1.15)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C223(1.00)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C223(1.15)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C223(1.16)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C223(0.99)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C223(1.00)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C223(1.25)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C223(0.92)  LDD1607  [1]
 LDCM0406  CL19 HEK-293T C223(1.03)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C223(1.01)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C223(1.08)  LDD1612  [1]
 LDCM0410  CL22 HEK-293T C223(1.21)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C223(1.43)  LDD1615  [1]
 LDCM0414  CL26 HEK-293T C223(0.98)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C223(1.03)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C223(0.87)  LDD1620  [1]
 LDCM0418  CL3 HEK-293T C223(1.24)  LDD1622  [1]
 LDCM0420  CL31 HEK-293T C223(1.05)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C223(1.13)  LDD1625  [1]
 LDCM0423  CL34 HEK-293T C223(1.30)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C223(1.12)  LDD1628  [1]
 LDCM0428  CL39 HEK-293T C223(1.04)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C223(1.07)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C223(0.94)  LDD1634  [1]
 LDCM0433  CL43 HEK-293T C223(1.08)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C223(1.07)  LDD1638  [1]
 LDCM0436  CL46 HEK-293T C223(1.22)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C223(0.94)  LDD1641  [1]
 LDCM0441  CL50 HEK-293T C223(0.97)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C223(0.90)  LDD1646  [1]
 LDCM0446  CL55 HEK-293T C223(1.05)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C223(1.08)  LDD1650  [1]
 LDCM0449  CL58 HEK-293T C223(1.33)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C223(1.07)  LDD1653  [1]
 LDCM0454  CL62 HEK-293T C223(0.97)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C223(1.00)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C223(1.07)  LDD1659  [1]
 LDCM0459  CL67 HEK-293T C223(1.02)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C223(1.18)  LDD1663  [1]
 LDCM0462  CL7 HEK-293T C223(1.12)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C223(1.18)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C223(1.08)  LDD1667  [1]
 LDCM0467  CL74 HEK-293T C223(0.97)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C223(0.89)  LDD1672  [1]
 LDCM0472  CL79 HEK-293T C223(0.96)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C223(1.59)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C223(1.00)  LDD1677  [1]
 LDCM0476  CL82 HEK-293T C223(1.15)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C223(1.32)  LDD1680  [1]
 LDCM0480  CL86 HEK-293T C223(0.99)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C223(1.19)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C223(0.99)  LDD1685  [1]
 LDCM0486  CL91 HEK-293T C223(1.13)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C223(1.06)  LDD1690  [1]
 LDCM0489  CL94 HEK-293T C223(1.16)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C223(1.62)  LDD1693  [1]
 LDCM0493  CL98 HEK-293T C223(0.88)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C223(1.08)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C223(1.03)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C223(1.00)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C223(0.98)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402