Details of the Target

General Information of Target

Target ID LDTP00022
Target Name Transmembrane protein 120B (TMEM120B)
Gene Name TMEM120B
Gene ID 144404
Synonyms
Transmembrane protein 120B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDLKLT
LQRCKRHASREEAELVQQMAANIKERQDVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQ
AKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDEVFNFLLVWYYCTLTIRESILIS
NGSRIKGWWVSHHYVSTFLSGVMLTWPNGPIYQKFRNQFLAFSIFQSCVQFLQYYYQRGC
LYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECRE
WQVFVLAFTFLILFLGNFLTTLKVVHAKLQKNRGKTKQP
Target Bioclass
Other
Family
TMEM120 family
Subcellular location
Nucleus inner membrane
Function Necessary for efficient adipogenesis. Does not show ion channel activity.
Uniprot ID
A0PK00
Ensemble ID
ENST00000342607.10
HGNC ID
HGNC:32008

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C43(0.71)  LDD3339  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [4]
OEA-DA
 Probe Info  		20.00  LDD0046  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C43(1.19)  LDD1507  [6]
 LDCM0226  AC11 HEK-293T C43(0.95)  LDD1509  [6]
 LDCM0259  AC14 HEK-293T C43(1.00)  LDD1512  [6]
 LDCM0276  AC17 HEK-293T C43(0.99)  LDD1515  [6]
 LDCM0278  AC19 HEK-293T C43(0.85)  LDD1517  [6]
 LDCM0282  AC22 HEK-293T C43(0.94)  LDD1521  [6]
 LDCM0284  AC24 HEK-293T C43(1.03)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C43(1.00)  LDD1524  [6]
 LDCM0287  AC27 HEK-293T C43(0.97)  LDD1526  [6]
 LDCM0290  AC3 HEK-293T C43(0.97)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C43(1.03)  LDD1530  [6]
 LDCM0293  AC32 HEK-293T C43(0.85)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C43(1.09)  LDD1533  [6]
 LDCM0296  AC35 HEK-293T C43(1.00)  LDD1535  [6]
 LDCM0299  AC38 HEK-293T C43(0.98)  LDD1538  [6]
 LDCM0302  AC40 HEK-293T C43(0.86)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C43(1.10)  LDD1542  [6]
 LDCM0305  AC43 HEK-293T C43(1.03)  LDD1544  [6]
 LDCM0308  AC46 HEK-293T C43(1.18)  LDD1547  [6]
 LDCM0310  AC48 HEK-293T C43(0.93)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C43(1.06)  LDD1550  [6]
 LDCM0314  AC51 HEK-293T C43(1.03)  LDD1553  [6]
 LDCM0317  AC54 HEK-293T C43(1.09)  LDD1556  [6]
 LDCM0319  AC56 HEK-293T C43(1.00)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C43(0.93)  LDD1559  [6]
 LDCM0322  AC59 HEK-293T C43(1.00)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C43(1.21)  LDD1562  [6]
 LDCM0326  AC62 HEK-293T C43(1.01)  LDD1565  [6]
 LDCM0328  AC64 HEK-293T C43(0.83)  LDD1567  [6]
 LDCM0345  AC8 HEK-293T C43(0.88)  LDD1569  [6]
 LDCM0356  AKOS034007680 HEK-293T C43(1.03)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C43(1.00)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C43(1.05)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C43(1.54)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C43(0.87)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C43(0.92)  LDD1574  [6]
 LDCM0372  CL103 HEK-293T C43(0.94)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C43(0.98)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C43(0.85)  LDD1578  [6]
 LDCM0376  CL107 HEK-293T C43(0.96)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C43(0.82)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C43(0.84)  LDD1582  [6]
 LDCM0381  CL111 HEK-293T C43(0.90)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C43(0.78)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C43(0.97)  LDD1587  [6]
 LDCM0385  CL115 HEK-293T C43(0.97)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C43(0.91)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C43(0.95)  LDD1591  [6]
 LDCM0389  CL119 HEK-293T C43(0.98)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C43(1.25)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C43(0.90)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C43(0.87)  LDD1596  [6]
 LDCM0394  CL123 HEK-293T C43(0.96)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C43(0.93)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C43(0.83)  LDD1600  [6]
 LDCM0398  CL127 HEK-293T C43(0.96)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C43(0.98)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C43(0.97)  LDD1604  [6]
 LDCM0402  CL15 HEK-293T C43(1.02)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C43(1.06)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C43(1.03)  LDD1608  [6]
 LDCM0406  CL19 HEK-293T C43(1.08)  LDD1610  [6]
 LDCM0410  CL22 HEK-293T C43(1.24)  LDD1614  [6]
 LDCM0412  CL24 HEK-293T C43(1.26)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C43(0.97)  LDD1617  [6]
 LDCM0415  CL27 HEK-293T C43(0.98)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C43(0.93)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C43(1.05)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C43(1.00)  LDD1622  [6]
 LDCM0420  CL31 HEK-293T C43(1.07)  LDD1624  [6]
 LDCM0423  CL34 HEK-293T C43(1.42)  LDD1627  [6]
 LDCM0425  CL36 HEK-293T C43(1.32)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C43(1.00)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C43(0.92)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C43(0.95)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C43(0.95)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C43(0.98)  LDD1635  [6]
 LDCM0433  CL43 HEK-293T C43(1.07)  LDD1637  [6]
 LDCM0436  CL46 HEK-293T C43(1.84)  LDD1640  [6]
 LDCM0438  CL48 HEK-293T C43(1.37)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C43(0.98)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C43(1.13)  LDD1644  [6]
 LDCM0443  CL52 HEK-293T C43(0.93)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C43(1.19)  LDD1647  [6]
 LDCM0446  CL55 HEK-293T C43(1.13)  LDD1649  [6]
 LDCM0449  CL58 HEK-293T C43(0.96)  LDD1652  [6]
 LDCM0452  CL60 HEK-293T C43(1.38)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C43(1.06)  LDD1656  [6]
 LDCM0455  CL63 HEK-293T C43(1.00)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C43(0.97)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C43(1.05)  LDD1660  [6]
 LDCM0459  CL67 HEK-293T C43(1.12)  LDD1662  [6]
 LDCM0462  CL7 HEK-293T C43(1.17)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C43(1.59)  LDD1666  [6]
 LDCM0465  CL72 HEK-293T C43(1.10)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C43(0.93)  LDD1669  [6]
 LDCM0469  CL76 HEK-293T C43(0.97)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C43(1.09)  LDD1673  [6]
 LDCM0472  CL79 HEK-293T C43(1.08)  LDD1675  [6]
 LDCM0476  CL82 HEK-293T C43(1.42)  LDD1679  [6]
 LDCM0478  CL84 HEK-293T C43(1.14)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C43(0.91)  LDD1682  [6]
 LDCM0481  CL87 HEK-293T C43(0.92)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C43(0.84)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C43(1.17)  LDD1686  [6]
 LDCM0486  CL91 HEK-293T C43(1.07)  LDD1689  [6]
 LDCM0489  CL94 HEK-293T C43(1.26)  LDD1692  [6]
 LDCM0491  CL96 HEK-293T C43(1.01)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C43(0.97)  LDD1695  [6]
 LDCM0494  CL99 HEK-293T C43(0.91)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C43(1.01)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C43(0.87)  LDD1671  [6]
 LDCM0022  KB02 8305C C43(1.39)  LDD2248  [1]
 LDCM0023  KB03 697 C43(1.43)  LDD2662  [1]
 LDCM0024  KB05 NALM-6 C43(0.71)  LDD3339  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
Palmitoyltransferase ZDHHC15 (ZDHHC15) DHHC palmitoyltransferase family Q96MV8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Glutamate decarboxylase 2 (GAD2) Group II decarboxylase family Q05329
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) MAPEG family P20292
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
E3 ubiquitin-protein ligase RNF19B (RNF19B) RBR family Q6ZMZ0
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin (STOM) Band 7/mec-2 family P27105
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Gap junction beta-1 protein (GJB1) Connexin family P08034
Excitatory amino acid transporter 1 (SLC1A3) Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family P43003
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Junctophilin-1 (JPH1) Junctophilin family Q9HDC5
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Aquaporin-8 (AQP8) MIP/aquaporin (TC 1.A.8) family O94778
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) NIP3 family O60238
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 139 (TMEM139) . Q8IV31
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
G-protein coupled receptor family C group 5 member D (GPRC5D) G-protein coupled receptor 3 family Q9NZD1
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-7 receptor subunit alpha (IL7R) Type I cytokine receptor family P16871
Interferon gamma receptor 2 (IFNGR2) Type II cytokine receptor family P38484
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein A-V (APOA5) Apolipoprotein A1/A4/E family Q6Q788
Small ribosomal subunit protein mS40 (MRPS18B) Bacterial ribosomal protein bS18 family Q9Y676
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Receptor expression-enhancing protein 2 (REEP2) DP1 family Q9BRK0
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Leucine-rich repeat transmembrane neuronal protein 2 (LRRTM2) LRRTM family O43300
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Ankyrin repeat and SAM domain-containing protein 6 (ANKS6) . Q68DC2
Transmembrane protein 143 (TMEM143) . Q96AN5
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
5 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402