Details of the Target

General Information of Target

Target ID LDTP20311
Target Name Uncharacterized protein C9orf40 (C9orf40)
Gene Name C9orf40
Gene ID 55071
Synonyms
Uncharacterized protein C9orf40
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELSSMKICAAIPTSRALPEVVRRMPRKRISGLEWLLQQDPGFSLVNTVKAGMIISFPSN
NIYSSVCCCQSEIFKYEFSNSKKSSWIQEERHLGKNNVLYSAHDVSPEKVTSALKKTNKQ
TTTINNFPLQYLPGSKLLDRFLSLSRSLLCLNSWSSSLPLAPQVKKK
Target Bioclass
Other
Uniprot ID
Q8IXQ3
Ensemble ID
ENST00000376854.6
HGNC ID
HGNC:23433

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K17(7.69)  LDD0277  [1]
m-APA
 Probe Info  		14.40  LDD0403  [2]
IA-alkyne
 Probe Info  		C22(1.55)  LDD2183  [3]
DBIA
 Probe Info  		C22(0.98)  LDD1492  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C22(1.06)  LDD1510  [4]
 LDCM0280  AC20 HEK-293T C22(1.13)  LDD1519  [4]
 LDCM0284  AC24 HEK-293T C22(1.06)  LDD1523  [4]
 LDCM0288  AC28 HEK-293T C22(1.06)  LDD1527  [4]
 LDCM0293  AC32 HEK-293T C22(1.25)  LDD1532  [4]
 LDCM0297  AC36 HEK-293T C22(1.10)  LDD1536  [4]
 LDCM0301  AC4 HEK-293T C22(1.09)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C22(1.11)  LDD1541  [4]
 LDCM0306  AC44 HEK-293T C22(1.27)  LDD1545  [4]
 LDCM0310  AC48 HEK-293T C22(1.27)  LDD1549  [4]
 LDCM0315  AC52 HEK-293T C22(1.09)  LDD1554  [4]
 LDCM0319  AC56 HEK-293T C22(1.00)  LDD1558  [4]
 LDCM0324  AC60 HEK-293T C22(1.19)  LDD1563  [4]
 LDCM0328  AC64 HEK-293T C22(1.29)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C22(0.88)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C22(1.15)  LDD1514  [4]
 LDCM0156  Aniline NCI-H1299 14.40  LDD0403  [2]
 LDCM0390  CL12 HEK-293T C22(1.00)  LDD1594  [4]
 LDCM0408  CL20 HEK-293T C22(1.30)  LDD1612  [4]
 LDCM0412  CL24 HEK-293T C22(1.04)  LDD1616  [4]
 LDCM0421  CL32 HEK-293T C22(1.10)  LDD1625  [4]
 LDCM0425  CL36 HEK-293T C22(1.17)  LDD1629  [4]
 LDCM0434  CL44 HEK-293T C22(1.41)  LDD1638  [4]
 LDCM0438  CL48 HEK-293T C22(1.51)  LDD1642  [4]
 LDCM0447  CL56 HEK-293T C22(1.17)  LDD1650  [4]
 LDCM0452  CL60 HEK-293T C22(1.18)  LDD1655  [4]
 LDCM0460  CL68 HEK-293T C22(0.92)  LDD1663  [4]
 LDCM0465  CL72 HEK-293T C22(1.40)  LDD1668  [4]
 LDCM0473  CL8 HEK-293T C22(1.10)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C22(1.07)  LDD1677  [4]
 LDCM0478  CL84 HEK-293T C22(1.17)  LDD1681  [4]
 LDCM0487  CL92 HEK-293T C22(1.29)  LDD1690  [4]
 LDCM0491  CL96 HEK-293T C22(1.01)  LDD1694  [4]
 LDCM0573  Fragment11 Ramos C22(2.28)  LDD2190  [3]
 LDCM0576  Fragment14 Ramos C22(1.86)  LDD2193  [3]
 LDCM0569  Fragment7 Ramos C22(1.73)  LDD2186  [3]
 LDCM0022  KB02 HEK-293T C22(0.98)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C22(1.02)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C22(1.04)  LDD1502  [4]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.