Details of the Target

General Information of Target

Target ID LDTP19774
Target Name Tetratricopeptide repeat protein 13 (TTC13)
Gene Name TTC13
Gene ID 79573
Synonyms
Tetratricopeptide repeat protein 13; TPR repeat protein 13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALKGQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSN
YFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFL
SVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISL
EKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALG
LQRSCLLTENKIRSLIYNALNPMHKEISQRSTATMYIIGGYYWHPLSEVHIWDPLTNVWI
QGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARY
YHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYV
IGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTITEC
YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIV
GNLPSAMRSHGCVCVYNV
Target Bioclass
Other
Uniprot ID
Q8NBP0
Ensemble ID
ENST00000366661.9
HGNC ID
HGNC:26204

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.M360V .
HCT15 SNV: p.A129V .
HT SNV: p.Q501R .
JHH7 SNV: p.G689E .
MEWO Substitution: p.P446L .
MOLT4 SNV: p.L432I .
NB4 SNV: p.E434D .
NCIH2286 SNV: p.A4S .
RD SNV: p.T675P .
RKO Deletion: p.T448RfsTer25
SNV: p.I620K		 .
SW1573 SNV: p.D655N .
SW403 SNV: p.S766Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K525(0.90)  LDD0277  [1]
m-APA
 Probe Info  		13.43  LDD0403  [2]
DBIA
 Probe Info  		C110(2.85)  LDD3380  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
AOyne
 Probe Info  		13.70  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C110(1.09)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C110(1.07)  LDD1508  [9]
 LDCM0237  AC12 HEK-293T C110(1.01)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C110(0.82)  LDD1512  [9]
 LDCM0276  AC17 HEK-293T C110(1.02)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C110(1.08)  LDD1516  [9]
 LDCM0279  AC2 HEK-293T C110(1.08)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C110(0.96)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C110(0.89)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C110(1.09)  LDD1521  [9]
 LDCM0285  AC25 HEK-293T C110(1.05)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C110(0.96)  LDD1525  [9]
 LDCM0288  AC28 HEK-293T C110(1.01)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C110(0.90)  LDD1528  [9]
 LDCM0291  AC30 HEK-293T C110(0.89)  LDD1530  [9]
 LDCM0294  AC33 HEK-293T C110(1.02)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C110(1.08)  LDD1534  [9]
 LDCM0297  AC36 HEK-293T C110(1.04)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C110(0.95)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C110(0.96)  LDD1538  [9]
 LDCM0301  AC4 HEK-293T C110(1.00)  LDD1540  [9]
 LDCM0303  AC41 HEK-293T C110(1.10)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C110(1.11)  LDD1543  [9]
 LDCM0306  AC44 HEK-293T C110(1.12)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C110(0.95)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C110(1.07)  LDD1547  [9]
 LDCM0311  AC49 HEK-293T C110(1.04)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C110(0.84)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C110(1.06)  LDD1552  [9]
 LDCM0315  AC52 HEK-293T C110(1.13)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C110(0.93)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C110(0.92)  LDD1556  [9]
 LDCM0320  AC57 HEK-293T C110(1.04)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C110(1.08)  LDD1560  [9]
 LDCM0323  AC6 HEK-293T C110(0.82)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C110(1.03)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C110(0.99)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C110(0.96)  LDD1565  [9]
 LDCM0248  AKOS034007472 HEK-293T C110(0.97)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C110(1.08)  LDD1570  [9]
 LDCM0156  Aniline NCI-H1299 13.43  LDD0403  [2]
 LDCM0367  CL1 HEK-293T C110(1.03)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C110(1.32)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C110(0.95)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C110(0.99)  LDD1574  [9]
 LDCM0372  CL103 HEK-293T C110(1.05); C505(1.21)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C110(0.99)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C110(1.02)  LDD1578  [9]
 LDCM0376  CL107 HEK-293T C110(1.04); C505(1.20)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C110(1.07)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C110(1.01)  LDD1582  [9]
 LDCM0381  CL111 HEK-293T C110(1.13); C505(1.20)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C110(0.91)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C110(1.00)  LDD1587  [9]
 LDCM0385  CL115 HEK-293T C110(1.05); C505(1.28)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C110(1.05)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C110(1.02)  LDD1591  [9]
 LDCM0389  CL119 HEK-293T C110(1.00); C505(1.26)  LDD1593  [9]
 LDCM0391  CL120 HEK-293T C110(0.93)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C110(0.99)  LDD1596  [9]
 LDCM0394  CL123 HEK-293T C110(0.97); C505(1.11)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C110(0.96)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C110(1.00)  LDD1600  [9]
 LDCM0398  CL127 HEK-293T C110(1.09); C505(1.34)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C110(0.94)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C110(1.15)  LDD1604  [9]
 LDCM0402  CL15 HEK-293T C110(1.14); C505(1.20)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C110(1.08)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C110(1.22)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C110(1.05)  LDD1609  [9]
 LDCM0408  CL20 HEK-293T C110(1.05)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C110(1.11)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C110(1.07)  LDD1614  [9]
 LDCM0413  CL25 HEK-293T C110(0.96)  LDD1617  [9]
 LDCM0415  CL27 HEK-293T C110(0.92); C505(1.30)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C110(0.92)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C110(1.06)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C110(0.97); C505(1.30)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C110(1.03)  LDD1623  [9]
 LDCM0421  CL32 HEK-293T C110(1.05)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C110(1.20)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C110(1.03)  LDD1627  [9]
 LDCM0426  CL37 HEK-293T C110(0.89)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C110(0.86); C505(1.14)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C110(0.93)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C110(0.99)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C110(1.07)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C110(1.04)  LDD1636  [9]
 LDCM0434  CL44 HEK-293T C110(1.00)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C110(1.01)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C110(0.81)  LDD1640  [9]
 LDCM0439  CL49 HEK-293T C110(1.00)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C110(1.13)  LDD1644  [9]
 LDCM0443  CL52 HEK-293T C110(1.07)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C110(1.01)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C110(1.01)  LDD1648  [9]
 LDCM0447  CL56 HEK-293T C110(1.11)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C110(1.15)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C110(1.18)  LDD1652  [9]
 LDCM0451  CL6 HEK-293T C110(1.25)  LDD1654  [9]
 LDCM0453  CL61 HEK-293T C110(0.86)  LDD1656  [9]
 LDCM0455  CL63 HEK-293T C110(0.93); C505(1.44)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C110(1.09)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C110(1.12)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C110(0.94)  LDD1661  [9]
 LDCM0460  CL68 HEK-293T C110(0.97)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C110(1.16)  LDD1664  [9]
 LDCM0463  CL70 HEK-293T C110(0.95)  LDD1666  [9]
 LDCM0466  CL73 HEK-293T C110(1.00)  LDD1669  [9]
 LDCM0469  CL76 HEK-293T C110(1.14)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C110(1.08)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C110(1.09)  LDD1674  [9]
 LDCM0473  CL8 HEK-293T C110(1.07)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C110(1.04)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C110(1.07)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C110(1.01)  LDD1679  [9]
 LDCM0479  CL85 HEK-293T C110(0.89)  LDD1682  [9]
 LDCM0481  CL87 HEK-293T C110(0.94); C505(1.25)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C110(1.06)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C110(1.07)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C110(1.07)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C110(0.70)  LDD1688  [9]
 LDCM0487  CL92 HEK-293T C110(1.17)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C110(1.00)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C110(0.99)  LDD1692  [9]
 LDCM0492  CL97 HEK-293T C110(1.00)  LDD1695  [9]
 LDCM0494  CL99 HEK-293T C110(0.90); C505(1.17)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C110(0.97); C505(1.15)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C110(1.04); C505(1.25)  LDD1671  [9]
 LDCM0022  KB02 HEK-293T C110(0.96)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C110(1.00)  LDD1497  [9]
 LDCM0024  KB05 OV-90 C110(2.85)  LDD3380  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402