Details of the Target

General Information of Target

Target ID LDTP19630
Target Name Leucine-rich repeat-containing protein 28 (LRRC28)
Gene Name LRRC28
Gene ID 123355
Synonyms
Leucine-rich repeat-containing protein 28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTRTQKGKTFLPHCFYQSLPPRLGWGMILNYSKLKGKEECASVSSVPMVFFSSQYRLHRK
SQYLKMAAANLTFSQEVVWQRGLPSIPYSQYSFDHLYNTNDIIHTPQIRKARPQKPVSFK
FLGSSSPLTGDTSLAVKTESSANPEKKLKKSKPASTVREAPRPLIHHPCMHPDMLGRPPS
LDVNLEEREAWLLPPEKEARAWEATVLEKLNERTARWIQSKRPRRPGASPNKWQSFLRQQ
YDWSHIRDELTSASDLELLKQLEAEETAEFEDQSVILPPQEKKKPELLLPVYYRLPSYFQ
QAETVEIMPGNKSTEDIHEKTSLSQPQTQSYFRQVTPRAGKFAYSTDNTFEQEIYFDEVQ
IIHQIGAKRDQIVLENLNRYNKQLSKVFPETPEKWSAQAIPEASYRPVQGALRWTALPTP
AKDMLLQVGEKDVPIKTRRLKKQAKSLQEDVTWELVVLRRMLKEWKTAWALIIEWHHETV
ENLLQSLGDLHDDVRIKAITTCATAALERPRIATSQRDSDKTIQDLPEVLLPALEAALCD
KNAHVRMAAAICQYAIQSHNPLARNIMQTALLKGNSVDSWAAAQCLALEGTATYPVIKRI
LHQLFTKKNEDTEEQSYILLSYLSEKTTLIHTMLAVELNSCQWKNRIVACQAFSRISGNV
CLDMKHKLIQLMWNDWNKEVRRAAAQALGQMSLGKEVHDIIRVKLGQGNSQERVEALYLI
GELKLMTAKLLPSFLHCFSDDFTAVRRAACLAAGALQIRDKMVLECLLNLMQRDPYWKIK
AFAIRALGQIGQVSPELTDLLLWAIHYEESPGVRLEACRSILALKLQGDRVRDTFLDVLL
LENHDAVLKEMYQTMKILNLGNEGNQEMLQEIKNRIKTLSQKDLLTHKILKLEMVMGKVR
EEAKRVYLKPKGEQGPLTLQTLLQETFQDEMVLPRRPSEVCDTEAVIKPVKPRAPNPWLQ
SSVPGLTTRSKVRSSLVKDLRTSPEKRIAVGPFRSDYPALYLGKFSERTFFSPIMSSPSG
KKGAHL
Target Bioclass
Other
Uniprot ID
Q86X40
Ensemble ID
ENST00000301981.8
HGNC ID
HGNC:28355

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU1 SNV: p.E204Ter .
HCT15 SNV: p.G340V .
HT1376 SNV: p.G280E .
SW1271 SNV: p.A235S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C92(14.92); C104(14.92)  LDD0209  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C156(0.70)  LDD1507  [2]
 LDCM0226  AC11 HEK-293T C156(0.67)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C6(1.07)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C6(1.14)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C156(1.02)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C156(0.88)  LDD1515  [2]
 LDCM0278  AC19 HEK-293T C156(0.99)  LDD1517  [2]
 LDCM0280  AC20 HEK-293T C6(1.02)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C156(0.92)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C6(0.99)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C156(1.05)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C156(0.76)  LDD1524  [2]
 LDCM0287  AC27 HEK-293T C156(1.04)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C6(0.98)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C156(1.45)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C156(1.30)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C6(0.94)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C156(0.84)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C156(1.11)  LDD1533  [2]
 LDCM0296  AC35 HEK-293T C156(0.66)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C6(0.93)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C156(1.16)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C6(1.08)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C156(0.91)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C6(0.87)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C156(0.63)  LDD1542  [2]
 LDCM0305  AC43 HEK-293T C156(0.84)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C6(0.98)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C156(1.03)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C6(1.00)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C156(0.90)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C156(0.72)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C156(1.04)  LDD1551  [2]
 LDCM0314  AC51 HEK-293T C156(0.77)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C6(1.02)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C156(1.00)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C6(1.01)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C156(0.91)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C156(0.93)  LDD1559  [2]
 LDCM0322  AC59 HEK-293T C156(0.64)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C6(0.90)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C6(1.05)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C156(1.16)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C6(1.03)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C156(0.86)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C156(0.78)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C156(1.71)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C156(1.25)  LDD1570  [2]
 LDCM0368  CL10 HEK-293T C6(6.78)  LDD1572  [2]
 LDCM0379  CL11 HEK-293T C156(0.69)  LDD1583  [2]
 LDCM0404  CL17 HEK-293T C156(0.48)  LDD1608  [2]
 LDCM0406  CL19 HEK-293T C156(0.84)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C6(3.39)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C156(0.96)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C6(4.85)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C156(0.90)  LDD1615  [2]
 LDCM0417  CL29 HEK-293T C156(0.76)  LDD1621  [2]
 LDCM0420  CL31 HEK-293T C156(0.80)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C6(2.26)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C156(0.91)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C6(4.97)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C156(1.06)  LDD1628  [2]
 LDCM0431  CL41 HEK-293T C156(0.62)  LDD1635  [2]
 LDCM0433  CL43 HEK-293T C156(0.85)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C6(2.07)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C156(0.97)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C6(4.27)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C156(0.78)  LDD1641  [2]
 LDCM0440  CL5 HEK-293T C156(0.82)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C156(0.87)  LDD1647  [2]
 LDCM0446  CL55 HEK-293T C156(1.19)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C6(2.80)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C156(1.21)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C6(4.61)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C156(0.87)  LDD1653  [2]
 LDCM0457  CL65 HEK-293T C156(0.75)  LDD1660  [2]
 LDCM0459  CL67 HEK-293T C156(1.03)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C6(2.53)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C156(0.83)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C156(0.95)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C6(3.36)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C156(0.85)  LDD1667  [2]
 LDCM0470  CL77 HEK-293T C156(0.74)  LDD1673  [2]
 LDCM0472  CL79 HEK-293T C156(0.74)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C6(5.16)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C6(1.77)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C156(1.05)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C6(2.52)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C156(0.85)  LDD1680  [2]
 LDCM0483  CL89 HEK-293T C156(0.75)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C156(1.06)  LDD1687  [2]
 LDCM0486  CL91 HEK-293T C156(0.68)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C6(1.71)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C156(0.87)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C6(2.17)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C156(0.90)  LDD1693  [2]
 LDCM0023  KB03 Jurkat C92(14.92); C104(14.92)  LDD0209  [1]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402