Details of the Target

General Information of Target

Target ID LDTP19405
Target Name EEIG family member 2 (EEIG2)
Gene Name EEIG2
Gene ID 284611
Synonyms
FAM102B; EEIG family member 2; EEIG2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY
VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK
VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG
YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI
EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI
QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE
EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN
ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAADLNPIF
Target Bioclass
Other
Family
EEIG family
Uniprot ID
Q5T8I3
Ensemble ID
ENST00000370035.8
HGNC ID
HGNC:27637

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G26R .
HEC1 SNV: p.K179N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C222(1.56)  LDD3333  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
TFBX
 Probe Info  		C201(0.00); C222(0.00)  LDD0027  [6]
IPM
 Probe Info  		N.A.  LDD0147  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C233(1.34)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C201(1.16)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C233(1.00)  LDD1509  [7]
 LDCM0276  AC17 HEK-293T C233(1.17)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C201(0.93)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C233(1.21)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C201(0.84)  LDD1518  [7]
 LDCM0284  AC24 HEK-293T C233(1.10)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C233(1.16)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C201(0.86)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C233(1.01)  LDD1526  [7]
 LDCM0290  AC3 HEK-293T C233(0.96)  LDD1529  [7]
 LDCM0293  AC32 HEK-293T C233(1.09)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C233(1.20)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C201(0.84)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C233(1.09)  LDD1535  [7]
 LDCM0302  AC40 HEK-293T C233(0.91)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C233(1.28)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C201(1.17)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C233(1.09)  LDD1544  [7]
 LDCM0310  AC48 HEK-293T C233(0.98)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C233(1.06)  LDD1550  [7]
 LDCM0313  AC50 HEK-293T C201(1.25)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C233(1.09)  LDD1553  [7]
 LDCM0319  AC56 HEK-293T C233(0.98)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C233(1.13)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C201(0.95)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C233(0.88)  LDD1561  [7]
 LDCM0328  AC64 HEK-293T C233(1.09)  LDD1567  [7]
 LDCM0345  AC8 HEK-293T C233(1.16)  LDD1569  [7]
 LDCM0356  AKOS034007680 HEK-293T C233(0.95)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C233(1.02)  LDD1514  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0632  CL-Sc Hep-G2 C282(20.00); C201(20.00); C222(4.91); C282(0.87)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C233(0.95)  LDD1571  [7]
 LDCM0369  CL100 HEK-293T C233(1.01); C201(1.48)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C233(0.83)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C233(0.88)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C233(0.78); C148(1.09)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C233(0.87); C201(1.06)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C233(1.15)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C233(0.95)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C233(0.82); C148(0.93)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C233(0.89); C201(1.22)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C233(0.91)  LDD1582  [7]
 LDCM0380  CL110 HEK-293T C233(1.02)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C233(0.80); C148(0.92)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C233(0.95); C201(1.25)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C233(1.22)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C233(1.14)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C233(0.69); C148(0.97)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C233(0.90); C201(1.45)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C233(1.05)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C233(1.00)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C233(0.77); C148(1.04)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C233(1.21)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C233(0.82); C201(1.54)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C233(0.98)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C233(1.12)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C233(0.70); C148(1.04)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C233(0.75); C201(1.38)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C233(0.70)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C233(1.15)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C233(0.73); C148(1.15)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C233(0.85); C201(1.16)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C233(0.82)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C233(0.99)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C233(0.66); C148(0.99)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C233(0.80); C201(0.85)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C233(1.37)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C201(0.88)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C233(1.06)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C233(0.89)  LDD1611  [7]
 LDCM0412  CL24 HEK-293T C233(1.13)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C233(0.85)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C233(1.00)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C233(0.81); C148(1.01)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C233(0.82); C201(1.28)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C233(1.02)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C233(0.79); C148(1.01)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C201(0.74)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C233(0.89)  LDD1624  [7]
 LDCM0425  CL36 HEK-293T C233(1.20)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C233(0.90)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C233(0.67); C148(0.91)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C233(0.84); C201(0.96)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C233(0.86); C201(0.81)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C233(1.07)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C201(0.90)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C233(1.12)  LDD1637  [7]
 LDCM0438  CL48 HEK-293T C233(1.06)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C233(0.86)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C233(1.28)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C233(1.11)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C233(0.93); C201(0.85)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C233(1.19)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C201(0.72)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C233(1.06)  LDD1649  [7]
 LDCM0451  CL6 HEK-293T C201(0.80)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C233(1.21)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C233(1.08)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C233(0.87)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C233(0.85); C148(0.99)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C233(1.55); C201(1.05)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C233(1.13)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C201(0.81)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C233(1.41)  LDD1662  [7]
 LDCM0462  CL7 HEK-293T C233(0.95)  LDD1665  [7]
 LDCM0465  CL72 HEK-293T C233(1.13)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C233(1.16)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C233(0.91)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C233(0.91); C201(0.99)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C233(0.86)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C201(0.68)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C233(0.91)  LDD1675  [7]
 LDCM0478  CL84 HEK-293T C233(1.05)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C233(0.75)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C233(0.79)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C233(0.74); C148(1.01)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C233(0.72); C201(0.94)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C233(0.95)  LDD1686  [7]
 LDCM0485  CL90 HEK-293T C201(0.65)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C233(0.80)  LDD1689  [7]
 LDCM0491  CL96 HEK-293T C233(0.86)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C233(0.96)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C233(1.17)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C233(0.63); C148(0.93)  LDD1697  [7]
 LDCM0634  CY-0357 Hep-G2 C233(0.80)  LDD2228  [5]
 LDCM0495  E2913 HEK-293T C233(0.79); C148(1.20)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C233(0.80); C148(1.02)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C233(0.80)  LDD1631  [7]
 LDCM0022  KB02 A101D C120(1.89)  LDD2250  [1]
 LDCM0023  KB03 A101D C120(2.78)  LDD2667  [1]
 LDCM0024  KB05 MOLM-13 C222(1.56)  LDD3333  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402