Details of the Target

General Information of Target

Target ID LDTP18577
Target Name Jerky protein homolog-like (JRKL)
Gene Name JRKL
Gene ID 8690
Synonyms
Jerky protein homolog-like; Human homolog of mouse jerky gene protein; HHMJG
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNLHQVLTGAVNPGDHCFSVGSIGDQRFTAYASGCDIVILGSDFERLQIIPGAKHGNIQV
GCVDCSMQQGKIAASYGNVISIFEPVNLPKQKKNLELYSQWQKSGQFFLESIAHNITWDP
TGSRLLTGSSYLQLWSNTNLEKPTEDENLNKTDLNFGDWKCIWHCKTASQVHLMKFSPDG
EFFATAGKDDCLLKVWYNVENWRTAVTSPDGSSEKQSQGEIDFSFVYLAHPRAVNGFSWR
KTSKYMPRASVCNVLLTCCKDNVCRLWVETFLPNDCLLYGGDCSHWTESINLTNNFKRNA
SSKERVQNALEVNLRHFRRGRRRSLALVAHTGYLPHQQDPHHVHRNTPLHANALCHFHIA
ASINPATDIPLLPSITSLSLNENEEKTGPFVVHWLNNKELHFTLSMEVFLQQLRKSFEQP
SSEASVEDSNQADVKSDEETDDGVDDLKINPEKKELGCDKMVPNSSFTSLSSAAIDHQIE
VLLSEWSKNADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQVQVSFVSRIPVAFPTGDAN
SLCKSIMMYACTKNVDLAIQQGKQKPSGLTRSTSMLISSGHNKSSNSLKLSIFTPNVMMI
SKHADGSLNQWLVSFAEESAFSTVLSISHKSRYCGHRFHLNDLACHSVLPLLLTTSHHNA
LRTPDVDNPEQPFDALNIEECSLTQQNKSTVDVAFQDPSAVYSELILWRVDPVGPLSFSG
GVSELARINSLHVSAFSNVAWLPTLIPSYCLGAYCNSPSACFVASDGQYLRLYEAVIDAK
KLLSELSNPEISKYVGEVFNIVSQQSTARPGCIIALDPITKLHGRKTQLLHVFEEDFILN
NLEKKSLGKDSILSNAGSSPNGFSEKFYLIVIECTQDNRSLLHMWNLHLKSIPVSLDEKV
DTKLSEAVWQPEEHYSSSPEKILSPFSQKYQACRANLQSTSRLTLFSEMVYSQELHLPEG
VEIISIKPSAGHLSSSSIYPACSAPYLLATSCSDEKVRFWRCRVTDGESATSKNGKIDLA
YIWEEWPLLIEDGLQSNSSITVPGRPVEVSCAHTNRLAVAYKQPASNSRSSQDFVMHVSI
FECESTGGSCWVLEQTIHLDELSTVLDSGISVDSNLVAYNKQDMYLSSKENITSNTKHLV
HLDWMSREDGSHILTVGIGSKLFMYGPLAGKVQDQTGKETLAFPLWESTKVVPLSKFVLL
RSVDLVSSVDGSPPFPVSLSWVRDGILVVGMDCEMHVYCQWQPSSKQEPVITDSYSGSTP
SITSLIKQSNSSSGLHPPKKTLTRSMTSLAQKICGKKTAFDPSVDMEDSGLFEAAHVLSP
TLPQYHPLQLLELMDLGKVRRAKAILSHLVKCIAGEVVALNEAESNHERRLRSLTISASG
STTRDPQAFNKAENTDYTEIDSVPPLPLYALLAADDDSCYSSLEKSSNESTLSKSNQLSK
ESYDELFQTQLLMTDTHMLETDEENTKPRVIDLSQYSPTYFGPEHAQVLSGHLLHSSLPG
LSRMEQMSLMALADTIATTSTDIGESRDRSQGGETLDECGLKFLLAVRLHTFLTTSLPAY
RAQLLHQGLSTSHFAWAFHSVAEEELLNMLPAMQKDDPTWSELRAMGVGWWVRNTRILRK
CIEKVAKAAFYRKNDPLDAAIFYLAMKKKAVIWGLYRAEKNTRMTQFFGHNFEDERWRKA
ALKNAFSLLGKQRFEHSAAFFLLAGCLRDAIEVCLEKLNDIQLALVIARLYESEFDTSAA
YKSILRKKVLGIDSPVSELCSLNINMHHDPFLRSMAYWILEDYSGALETLIKQPIRENDD
QVLSASNPTVFNFYNYLRTHPLLLRRHFGSSDTFSTHMSLTGKSGLAGTINLSERRLFFT
TASAHLKAGCPMLALEVLSKMPKVIKKTRPFYRASSFLDTSKDCSPSSPLKLDAREDKSS
AVDWSQSLINGFGSSSEGSSEKQSNSTLSFDWSQPSVVFQDDSLELKWDSDNDEENEDVP
ISMKELKPLQRKTDKKLDDISSNYTESFSTLDENDLLNPSEDIIAVQLKFRACLKILTVE
LRTLSTGYEIDGGKLRYQLYHWLEKEVIALQRTCDFCSDAEELQSAFGRNEDEFGLNEDA
EDLPHQTKVKQLRENFQEKRQWLLKYQSLLRMFLSYCILHGSHGGGLASVRMELILLLQE
SQQETSEPLFSSPLSEQTSVPLLFACTANAKTVVANPLLHLSNLTHDILHAIINFDSPPH
PDIQSNKVYVMHTLAASLSACIYQCLCGSHNYSSFQTNQFTGMVYQTVLLPHRPSLKTGS
LDEALTPNTSPAQWPGITCLIRLLNSSGEEAQSGLTVLLCEILTAVYLSLFIHGLATHSS
NELFRIVAHPLNEKMWSAVFGGGAHVPSKEQTHSKTLPVSSLVEEGEKQNKRFRPSKMSC
RESAPLTPSSAPVSQESLAVKEKFIPPELSIWDYFIAKPFLPSSQSRAEYDSEESLGSDD
DDNDDDDDVLASDFHLQEHSNSNSYSWSLMRLAMVQLVLNNLKTFYPFAGHDLAELPVSS
PLCHAVLKTLQCWEQVLLRRLEIHGGPPQNYIASHTAEESLSAGPAILRHKALLEPTNTP
FKSKHHLALSVKRLWQYLVKQEEIQETFIKNIFTKKRCLNEIEADLGYPGGKARIIHKES
DIITAFAVNKANRNCIAIASSHDVQELDVSGILATQVYTWVDDDIEVETKGSEDFLVIHA
RDDLTAVQGTTPYTHSNPGTPINMPWLGSTQTGRGASVMIKKAINNVRRMTSHPTLPYYL
TGAQDGSVRMFEWGHSQQITCFRSGGNSRVTRMRFNYQGNKFGIVDADGYLSLYQTNWKC
CPVTGSMPKPYLTWQCHNKTANDFVFVSSSSLIATAGLSTDNRNVCLWDTLVAPANSLVH
AFTCHDSGATVLAYAPKHQLLISGGRKGFTYVFDLCQRQQRQLFQSHDSPVKAVAVDPTE
EYFVTGSAEGNIKIWSLSTFGLLHTFVSEHARQSIFRNIGTGVMQIETGPANHIFSCGAD
GTMKMRILPDQFSPLNEVLKNDVKFML
Target Bioclass
Other
Family
Tigger transposable element derived protein family
Subcellular location
Nucleus
Uniprot ID
Q9Y4A0
Ensemble ID
ENST00000332349.5
HGNC ID
HGNC:6200

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C102(3.28)  LDD3369  [1]
IPM
 Probe Info  		C197(1.01)  LDD1702  [2]
Compound 10
 Probe Info  		N.A.  LDD2216  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C102(1.07)  LDD1509  [5]
 LDCM0259  AC14 HEK-293T C102(0.90)  LDD1512  [5]
 LDCM0278  AC19 HEK-293T C102(0.89)  LDD1517  [5]
 LDCM0282  AC22 HEK-293T C102(0.99)  LDD1521  [5]
 LDCM0284  AC24 HEK-293T C102(0.91)  LDD1523  [5]
 LDCM0287  AC27 HEK-293T C102(1.14)  LDD1526  [5]
 LDCM0290  AC3 HEK-293T C102(0.94)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C102(0.97)  LDD1530  [5]
 LDCM0293  AC32 HEK-293T C102(0.89)  LDD1532  [5]
 LDCM0296  AC35 HEK-293T C102(1.10)  LDD1535  [5]
 LDCM0299  AC38 HEK-293T C102(1.06)  LDD1538  [5]
 LDCM0302  AC40 HEK-293T C102(0.80)  LDD1541  [5]
 LDCM0305  AC43 HEK-293T C102(1.03)  LDD1544  [5]
 LDCM0308  AC46 HEK-293T C102(0.99)  LDD1547  [5]
 LDCM0310  AC48 HEK-293T C102(0.78)  LDD1549  [5]
 LDCM0314  AC51 HEK-293T C102(1.02)  LDD1553  [5]
 LDCM0317  AC54 HEK-293T C102(0.92)  LDD1556  [5]
 LDCM0319  AC56 HEK-293T C102(0.95)  LDD1558  [5]
 LDCM0322  AC59 HEK-293T C102(1.13)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C102(0.84)  LDD1562  [5]
 LDCM0326  AC62 HEK-293T C102(1.01)  LDD1565  [5]
 LDCM0328  AC64 HEK-293T C102(1.16)  LDD1567  [5]
 LDCM0345  AC8 HEK-293T C102(1.13)  LDD1569  [5]
 LDCM0275  AKOS034007705 HEK-293T C102(0.91)  LDD1514  [5]
 LDCM0368  CL10 HEK-293T C102(1.49)  LDD1572  [5]
 LDCM0390  CL12 HEK-293T C102(0.82)  LDD1594  [5]
 LDCM0406  CL19 HEK-293T C102(1.38)  LDD1610  [5]
 LDCM0410  CL22 HEK-293T C102(1.29)  LDD1614  [5]
 LDCM0412  CL24 HEK-293T C102(0.92)  LDD1616  [5]
 LDCM0420  CL31 HEK-293T C102(1.19)  LDD1624  [5]
 LDCM0423  CL34 HEK-293T C102(1.18)  LDD1627  [5]
 LDCM0425  CL36 HEK-293T C102(1.18)  LDD1629  [5]
 LDCM0433  CL43 HEK-293T C102(1.25)  LDD1637  [5]
 LDCM0436  CL46 HEK-293T C102(1.01)  LDD1640  [5]
 LDCM0438  CL48 HEK-293T C102(1.02)  LDD1642  [5]
 LDCM0446  CL55 HEK-293T C102(1.26)  LDD1649  [5]
 LDCM0449  CL58 HEK-293T C102(1.27)  LDD1652  [5]
 LDCM0452  CL60 HEK-293T C102(1.68)  LDD1655  [5]
 LDCM0459  CL67 HEK-293T C102(1.29)  LDD1662  [5]
 LDCM0462  CL7 HEK-293T C102(1.29)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C102(1.16)  LDD1666  [5]
 LDCM0465  CL72 HEK-293T C102(0.92)  LDD1668  [5]
 LDCM0472  CL79 HEK-293T C102(1.02)  LDD1675  [5]
 LDCM0476  CL82 HEK-293T C102(1.11)  LDD1679  [5]
 LDCM0478  CL84 HEK-293T C102(1.02)  LDD1681  [5]
 LDCM0486  CL91 HEK-293T C102(1.11)  LDD1689  [5]
 LDCM0489  CL94 HEK-293T C102(1.36)  LDD1692  [5]
 LDCM0491  CL96 HEK-293T C102(0.81)  LDD1694  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C197(1.01)  LDD1702  [2]
 LDCM0022  KB02 HEK-293T C102(0.92)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C102(0.92)  LDD1497  [5]
 LDCM0024  KB05 OAW-42 C102(3.28)  LDD3369  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402