Details of the Target

General Information of Target

Target ID LDTP18535
Target Name Zinc finger protein 107 (ZNF107)
Gene Name ZNF107
Gene ID 51427
Synonyms
ZFD25; ZNF588; Zinc finger protein 107; Zinc finger protein 588; Zinc finger protein ZFD25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTCTDQKSHSQRALGTQTPALQGPQLLNTDPSSEETRPPHVNPDRLCHMEPANHFWHAGD
LQAMISKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPP
SGIHLSASRTLAPTLLYSSPPSHSPFGLSSLI
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9UII5
Ensemble ID
ENST00000344930.7
HGNC ID
HGNC:12887

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C78(91.02)  LDD0209  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
HHS-465
 Probe Info  		K158(0.00); K161(0.00); Y160(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C54(1.01); C647(1.03)  LDD1513  [4]
 LDCM0281  AC21 HEK-293T C54(1.03)  LDD1520  [4]
 LDCM0283  AC23 HEK-293T C54(1.00); C647(1.09)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C54(0.94)  LDD1523  [4]
 LDCM0289  AC29 HEK-293T C54(1.10)  LDD1528  [4]
 LDCM0292  AC31 HEK-293T C54(0.97); C647(0.99)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C54(0.96)  LDD1532  [4]
 LDCM0298  AC37 HEK-293T C54(1.00)  LDD1537  [4]
 LDCM0300  AC39 HEK-293T C54(1.03); C647(0.95)  LDD1539  [4]
 LDCM0302  AC40 HEK-293T C54(0.92)  LDD1541  [4]
 LDCM0307  AC45 HEK-293T C54(1.06)  LDD1546  [4]
 LDCM0309  AC47 HEK-293T C54(0.96); C647(0.99)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C54(0.97)  LDD1549  [4]
 LDCM0312  AC5 HEK-293T C54(1.02)  LDD1551  [4]
 LDCM0316  AC53 HEK-293T C54(1.01)  LDD1555  [4]
 LDCM0318  AC55 HEK-293T C54(1.04); C647(0.92)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C54(0.95)  LDD1558  [4]
 LDCM0325  AC61 HEK-293T C54(1.02)  LDD1564  [4]
 LDCM0327  AC63 HEK-293T C54(1.05); C647(1.05)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C54(0.94)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C54(1.02); C647(0.91)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C54(0.97)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C54(1.02)  LDD1511  [4]
 LDCM0275  AKOS034007705 HEK-293T C54(1.00)  LDD1514  [4]
 LDCM0379  CL11 HEK-293T C54(0.98); C647(1.59)  LDD1583  [4]
 LDCM0390  CL12 HEK-293T C54(1.10)  LDD1594  [4]
 LDCM0409  CL21 HEK-293T C54(1.02)  LDD1613  [4]
 LDCM0411  CL23 HEK-293T C54(1.03); C647(1.48)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C54(0.98)  LDD1616  [4]
 LDCM0422  CL33 HEK-293T C54(0.95)  LDD1626  [4]
 LDCM0424  CL35 HEK-293T C54(1.05); C647(1.78)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C54(0.92)  LDD1629  [4]
 LDCM0435  CL45 HEK-293T C54(1.01)  LDD1639  [4]
 LDCM0437  CL47 HEK-293T C54(0.96); C647(1.80)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C54(1.02)  LDD1642  [4]
 LDCM0448  CL57 HEK-293T C54(1.20)  LDD1651  [4]
 LDCM0450  CL59 HEK-293T C54(1.05); C647(1.59)  LDD1653  [4]
 LDCM0452  CL60 HEK-293T C54(1.05)  LDD1655  [4]
 LDCM0461  CL69 HEK-293T C54(1.02)  LDD1664  [4]
 LDCM0464  CL71 HEK-293T C54(1.07); C647(1.60)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C54(1.10)  LDD1668  [4]
 LDCM0475  CL81 HEK-293T C54(1.04)  LDD1678  [4]
 LDCM0477  CL83 HEK-293T C54(1.01); C647(1.19)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C54(0.96)  LDD1681  [4]
 LDCM0484  CL9 HEK-293T C54(1.02)  LDD1687  [4]
 LDCM0488  CL93 HEK-293T C54(0.95)  LDD1691  [4]
 LDCM0490  CL95 HEK-293T C54(0.96); C647(1.29)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C54(0.99)  LDD1694  [4]
 LDCM0022  KB02 HEK-293T C647(0.96)  LDD1492  [4]
 LDCM0023  KB03 Jurkat C78(91.02)  LDD0209  [1]
 LDCM0024  KB05 SKMEL24 C54(0.96)  LDD3323  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840