Details of the Target

General Information of Target

Target ID LDTP18279
Target Name Stromal cell-derived factor 2 (SDF2)
Gene Name SDF2
Gene ID 6388
Synonyms
Stromal cell-derived factor 2; SDF-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVSLNHPASNTTSTKNNNSAFFYFESCQPPSPALLLLCIAYTVVLIVGLFGNLSLIIII
FKKQRKAQNFTSILIANLSLSDTLVCVMCIHFTIIYTLMDHWIFGDTMCRLTSYVQSVSI
SVSIFSLVFTAVERYQLIVNPRGWKPSVTHAYWGITLIWLFSLLLSIPFFLSYHLTDEPF
RNLSLPTDLYTHQVACVENWPSKKDRLLFTTSLFLLQYFVPLGFILICYLKIVICLRRRN
AKVDKKKENEGRLNENKRINTMLISIVVTFGACWLPRISSMSSLTGIMRC
Target Bioclass
Other
Subcellular location
Secreted
Uniprot ID
Q99470
Ensemble ID
ENST00000247020.9
HGNC ID
HGNC:10675

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y187(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K151(8.99); K197(3.99); K87(7.75)  LDD0277  [2]
DBIA
 Probe Info  		C88(4.32); C80(2.15)  LDD3311  [3]
BTD
 Probe Info  		C80(2.16); C26(1.48)  LDD1700  [4]
HHS-475
 Probe Info  		Y187(0.53)  LDD0264  [5]
Acrolein
 Probe Info  		C26(0.00); C80(0.00); H207(0.00)  LDD0222  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
NAIA_5
 Probe Info  		C88(0.00); C80(0.00); C137(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C88(0.51)  LDD2095  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C26(0.81); C80(0.86)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C26(1.13); C80(1.44)  LDD2152  [4]
 LDCM0215  AC10 PaTu 8988t C80(0.99)  LDD1094  [9]
 LDCM0216  AC100 PaTu 8988t C80(1.02)  LDD1095  [9]
 LDCM0217  AC101 PaTu 8988t C80(1.09)  LDD1096  [9]
 LDCM0218  AC102 PaTu 8988t C80(1.42)  LDD1097  [9]
 LDCM0219  AC103 PaTu 8988t C80(0.99)  LDD1098  [9]
 LDCM0220  AC104 PaTu 8988t C80(1.79)  LDD1099  [9]
 LDCM0221  AC105 PaTu 8988t C80(0.98)  LDD1100  [9]
 LDCM0222  AC106 PaTu 8988t C80(1.05)  LDD1101  [9]
 LDCM0223  AC107 PaTu 8988t C80(0.82)  LDD1102  [9]
 LDCM0224  AC108 PaTu 8988t C80(1.07)  LDD1103  [9]
 LDCM0225  AC109 PaTu 8988t C80(1.70)  LDD1104  [9]
 LDCM0226  AC11 PaTu 8988t C80(1.11)  LDD1105  [9]
 LDCM0227  AC110 PaTu 8988t C80(1.38)  LDD1106  [9]
 LDCM0228  AC111 PaTu 8988t C80(1.36)  LDD1107  [9]
 LDCM0229  AC112 PaTu 8988t C80(1.09)  LDD1108  [9]
 LDCM0237  AC12 PaTu 8988t C80(0.73)  LDD1116  [9]
 LDCM0259  AC14 PaTu 8988t C80(0.76)  LDD1138  [9]
 LDCM0270  AC15 PaTu 8988t C80(0.87)  LDD1149  [9]
 LDCM0308  AC46 PaTu 8988t C80(3.06)  LDD1187  [9]
 LDCM0309  AC47 PaTu 8988t C80(0.80)  LDD1188  [9]
 LDCM0310  AC48 PaTu 8988t C80(0.63)  LDD1189  [9]
 LDCM0311  AC49 PaTu 8988t C80(0.81)  LDD1190  [9]
 LDCM0313  AC50 PaTu 8988t C80(0.94)  LDD1192  [9]
 LDCM0314  AC51 PaTu 8988t C80(0.89)  LDD1193  [9]
 LDCM0315  AC52 PaTu 8988t C80(0.99)  LDD1194  [9]
 LDCM0316  AC53 PaTu 8988t C80(1.18)  LDD1195  [9]
 LDCM0317  AC54 PaTu 8988t C80(3.69)  LDD1196  [9]
 LDCM0318  AC55 PaTu 8988t C80(0.61)  LDD1197  [9]
 LDCM0319  AC56 PaTu 8988t C80(3.27)  LDD1198  [9]
 LDCM0323  AC6 PaTu 8988t C80(1.28)  LDD1202  [9]
 LDCM0334  AC7 PaTu 8988t C80(0.73)  LDD1213  [9]
 LDCM0345  AC8 PaTu 8988t C80(1.01)  LDD1224  [9]
 LDCM0365  AC98 PaTu 8988t C80(1.30)  LDD1244  [9]
 LDCM0366  AC99 PaTu 8988t C80(0.95)  LDD1245  [9]
 LDCM0545  Acetamide MDA-MB-231 C26(0.70)  LDD2138  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C80(1.20)  LDD1127  [9]
 LDCM0356  AKOS034007680 PaTu 8988t C80(0.75)  LDD1235  [9]
 LDCM0275  AKOS034007705 PaTu 8988t C80(1.13)  LDD1154  [9]
 LDCM0498  BS-3668 MDA-MB-231 C88(0.41)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C26(0.00); C80(0.00); H207(0.00)  LDD0222  [6]
 LDCM0367  CL1 PaTu 8988t C80(1.13)  LDD1246  [9]
 LDCM0368  CL10 PaTu 8988t C80(0.77)  LDD1247  [9]
 LDCM0370  CL101 PaTu 8988t C80(0.68)  LDD1249  [9]
 LDCM0371  CL102 PaTu 8988t C80(0.85)  LDD1250  [9]
 LDCM0372  CL103 PaTu 8988t C80(1.12)  LDD1251  [9]
 LDCM0373  CL104 PaTu 8988t C80(0.97)  LDD1252  [9]
 LDCM0379  CL11 PaTu 8988t C80(0.95)  LDD1258  [9]
 LDCM0390  CL12 PaTu 8988t C80(1.15)  LDD1269  [9]
 LDCM0392  CL121 PaTu 8988t C80(0.88)  LDD1271  [9]
 LDCM0393  CL122 PaTu 8988t C80(10.70)  LDD1272  [9]
 LDCM0394  CL123 PaTu 8988t C80(0.86)  LDD1273  [9]
 LDCM0395  CL124 PaTu 8988t C80(1.25)  LDD1274  [9]
 LDCM0400  CL13 PaTu 8988t C80(0.81)  LDD1279  [9]
 LDCM0401  CL14 PaTu 8988t C80(0.98)  LDD1280  [9]
 LDCM0402  CL15 PaTu 8988t C80(0.83)  LDD1281  [9]
 LDCM0403  CL16 PaTu 8988t C80(1.28)  LDD1282  [9]
 LDCM0404  CL17 PaTu 8988t C80(1.51)  LDD1283  [9]
 LDCM0405  CL18 PaTu 8988t C80(1.16)  LDD1284  [9]
 LDCM0406  CL19 PaTu 8988t C80(1.10)  LDD1285  [9]
 LDCM0407  CL2 PaTu 8988t C80(0.90)  LDD1286  [9]
 LDCM0408  CL20 PaTu 8988t C80(1.50)  LDD1287  [9]
 LDCM0409  CL21 PaTu 8988t C80(1.15)  LDD1288  [9]
 LDCM0410  CL22 PaTu 8988t C80(1.23)  LDD1289  [9]
 LDCM0411  CL23 PaTu 8988t C80(1.18)  LDD1290  [9]
 LDCM0412  CL24 PaTu 8988t C80(1.16)  LDD1291  [9]
 LDCM0413  CL25 PaTu 8988t C80(1.18)  LDD1292  [9]
 LDCM0414  CL26 PaTu 8988t C80(1.34)  LDD1293  [9]
 LDCM0415  CL27 PaTu 8988t C80(1.35)  LDD1294  [9]
 LDCM0416  CL28 PaTu 8988t C80(1.11)  LDD1295  [9]
 LDCM0417  CL29 PaTu 8988t C80(0.81)  LDD1296  [9]
 LDCM0418  CL3 PaTu 8988t C80(1.15)  LDD1297  [9]
 LDCM0419  CL30 PaTu 8988t C80(1.01)  LDD1298  [9]
 LDCM0429  CL4 PaTu 8988t C80(1.05)  LDD1308  [9]
 LDCM0440  CL5 PaTu 8988t C80(0.74)  LDD1319  [9]
 LDCM0451  CL6 PaTu 8988t C80(1.13)  LDD1330  [9]
 LDCM0462  CL7 PaTu 8988t C80(0.93)  LDD1341  [9]
 LDCM0473  CL8 PaTu 8988t C80(0.82)  LDD1352  [9]
 LDCM0484  CL9 PaTu 8988t C80(0.88)  LDD1363  [9]
 LDCM0116  HHS-0101 DM93 Y187(0.53)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y187(0.66)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y187(0.74)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y187(0.80)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y187(0.48)  LDD0268  [5]
 LDCM0022  KB02 A2058 C88(2.15)  LDD2253  [3]
 LDCM0023  KB03 A2780 C88(4.00); C80(2.64)  LDD2671  [3]
 LDCM0024  KB05 G361 C88(4.32); C80(2.15)  LDD3311  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C88(0.47)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C88(0.46); C80(0.85)  LDD2089  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C26(1.12); C80(0.81)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C88(0.71)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C88(0.56); C26(1.06); C80(0.96)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C88(0.53); C26(0.89); C80(0.67)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C26(1.04); C80(0.94)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C88(0.72); C26(0.84); C80(0.73)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C88(1.61); C26(0.59)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C88(2.74); C26(1.53); C80(2.21)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C88(0.62); C26(0.81)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C88(0.72); C26(0.72); C80(0.84)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C88(0.86); C26(0.74); C80(0.86)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C26(0.96); C80(0.91)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C26(0.55)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C26(1.60); C80(0.93)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C26(1.33); C80(1.16)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C26(0.84)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C80(2.16); C26(1.48)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C88(0.40); C26(0.67)  LDD2140  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C80(2.75)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C88(0.44)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C88(0.39); C80(1.12)  LDD2150  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Malonate Ion . DB02201

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.