Details of the Target

General Information of Target

Target ID LDTP18213
Target Name Zinc finger protein 778 (ZNF778)
Gene Name ZNF778
Gene ID 197320
Synonyms
Zinc finger protein 778
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLLFLAVLRPHTGNAVTAQRVRAHLEAAGHVCVLKDAFDFESRSEIANLILAENCEAAL
ALHLYRGGRLLQGHRIPFGVIFGGTDVNEDANQAEKNTVMGRVLEEARFAVAFTESMKEM
AQAQWPHAKGKVYVQSQGIATTPNAAFNWNTFLQRSEINQSADNLHIFLLICGLRQVKDP
LYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVK
NCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAK
RLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIRKLEGSTED
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q96MU6
Ensemble ID
ENST00000306502.6
HGNC ID
HGNC:26479

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C451(2.31)  LDD0170  [1]
DBIA
 Probe Info  		C281(0.85); C286(0.85)  LDD0078  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C451(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C451(2.25)  LDD0171  [1]
 LDCM0284  AC24 HEK-293T C379(1.05)  LDD1523  [3]
 LDCM0293  AC32 HEK-293T C379(0.81)  LDD1532  [3]
 LDCM0302  AC40 HEK-293T C379(0.95)  LDD1541  [3]
 LDCM0310  AC48 HEK-293T C379(1.30)  LDD1549  [3]
 LDCM0319  AC56 HEK-293T C379(1.04)  LDD1558  [3]
 LDCM0328  AC64 HEK-293T C379(0.94)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C379(1.06)  LDD1569  [3]
 LDCM0275  AKOS034007705 HEK-293T C379(0.93)  LDD1514  [3]
 LDCM0020  ARS-1620 HCC44 C281(0.85); C286(0.85)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C431(0.94)  LDD1571  [3]
 LDCM0370  CL101 HEK-293T C431(0.81)  LDD1574  [3]
 LDCM0374  CL105 HEK-293T C431(1.00)  LDD1578  [3]
 LDCM0378  CL109 HEK-293T C431(1.01)  LDD1582  [3]
 LDCM0383  CL113 HEK-293T C431(0.92)  LDD1587  [3]
 LDCM0387  CL117 HEK-293T C431(1.03)  LDD1591  [3]
 LDCM0390  CL12 HEK-293T C379(1.14)  LDD1594  [3]
 LDCM0392  CL121 HEK-293T C431(1.00)  LDD1596  [3]
 LDCM0396  CL125 HEK-293T C431(0.67)  LDD1600  [3]
 LDCM0400  CL13 HEK-293T C431(1.10)  LDD1604  [3]
 LDCM0412  CL24 HEK-293T C379(1.03)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C431(0.98)  LDD1617  [3]
 LDCM0425  CL36 HEK-293T C379(1.12)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C431(1.34)  LDD1630  [3]
 LDCM0438  CL48 HEK-293T C379(0.82)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C431(1.00)  LDD1643  [3]
 LDCM0452  CL60 HEK-293T C379(1.20)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C431(0.78)  LDD1656  [3]
 LDCM0465  CL72 HEK-293T C379(1.12)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C431(1.35)  LDD1669  [3]
 LDCM0478  CL84 HEK-293T C379(0.91)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C431(0.81)  LDD1682  [3]
 LDCM0491  CL96 HEK-293T C379(0.77)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C431(0.99)  LDD1695  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402