Details of the Target

General Information of Target

Target ID LDTP18198
Target Name Zinc finger protein 354B (ZNF354B)
Gene Name ZNF354B
Gene ID 117608
Synonyms
Zinc finger protein 354B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDVVGENEALQQFFEAQGANGTLENPALDTSLLEEFLGNDFDLGALQRQLPDTPPYSASD
SCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSCQIHGGFHSC
HSNASHLATPLDQSVSSHLGIGCSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWA
CHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVPWHSLLNSHYEKLPDVG
YRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIEMFYLKVFGT
KVEATNQIIAIEQSQADRSKKIFNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPN
PDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFENDSDALWQRGQVPESIVC
HGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRIAQMRIVEYD
YKPEFASAMGINTAHQTGMIAQEVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFME
NVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASEASTISKSSRAVSASSP
RRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFCALTIVALYILSLKDQDRRVPN
LPPSNITSSQEPALLPTASSSAPNTSLVTTPASLQVPEITFCEILPCQETYCCPIRGMKE
VSSSPVQRQSEEKEFHQRRWSEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQII
DHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKR
GTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTD
YFFYFYRRCA
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Transcriptional repressor that binds DNA upon activation by RAS proteins signal transduction to initiate transcriptional silencing through the recruitment of additional DNA-binding proteins, multisubunit complexes and chromatin-modifying activities to establish a platform for DNMT1 recruitment.
Uniprot ID
Q96LW1
Ensemble ID
ENST00000322434.8
HGNC ID
HGNC:17197

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C505(1.52)  LDD3383  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C286(0.89)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C286(1.27)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C286(1.02)  LDD1510  [3]
 LDCM0277  AC18 HEK-293T C286(0.97)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C286(1.41)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C286(0.89)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C286(0.94)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C87(0.94)  LDD1520  [3]
 LDCM0284  AC24 HEK-293T C87(0.89)  LDD1523  [3]
 LDCM0286  AC26 HEK-293T C286(0.98)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C286(1.26)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C286(1.08)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C87(0.99)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C286(1.21)  LDD1529  [3]
 LDCM0293  AC32 HEK-293T C87(0.88)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C286(1.06)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C286(1.07)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C286(1.13)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C87(1.20)  LDD1537  [3]
 LDCM0301  AC4 HEK-293T C286(1.00)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C87(1.14)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C286(1.01)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C286(1.14)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C286(1.09)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C87(0.98)  LDD1546  [3]
 LDCM0310  AC48 HEK-293T C87(1.10)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C87(1.06)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C286(0.97)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C286(1.13)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C286(1.05)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C87(1.04)  LDD1555  [3]
 LDCM0319  AC56 HEK-293T C87(1.11)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C286(0.99)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C286(1.07)  LDD1561  [3]
 LDCM0324  AC60 HEK-293T C286(1.02)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C87(0.94)  LDD1564  [3]
 LDCM0328  AC64 HEK-293T C87(0.93)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C87(0.96)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C87(0.99)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C87(1.12)  LDD1514  [3]
 LDCM0372  CL103 HEK-293T C87(0.86)  LDD1576  [3]
 LDCM0376  CL107 HEK-293T C87(0.94)  LDD1580  [3]
 LDCM0381  CL111 HEK-293T C87(1.16)  LDD1585  [3]
 LDCM0385  CL115 HEK-293T C87(0.97)  LDD1589  [3]
 LDCM0389  CL119 HEK-293T C87(1.00)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C87(0.93)  LDD1594  [3]
 LDCM0394  CL123 HEK-293T C87(0.98)  LDD1598  [3]
 LDCM0398  CL127 HEK-293T C87(1.13)  LDD1602  [3]
 LDCM0402  CL15 HEK-293T C87(0.97)  LDD1606  [3]
 LDCM0405  CL18 HEK-293T C286(1.01)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C286(1.44)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C286(1.22)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C87(1.10)  LDD1613  [3]
 LDCM0412  CL24 HEK-293T C87(1.03)  LDD1616  [3]
 LDCM0415  CL27 HEK-293T C87(1.09)  LDD1619  [3]
 LDCM0418  CL3 HEK-293T C87(1.22)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C286(0.99)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C286(1.14)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C286(0.96)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C87(1.15)  LDD1626  [3]
 LDCM0425  CL36 HEK-293T C87(0.96)  LDD1629  [3]
 LDCM0428  CL39 HEK-293T C87(1.36)  LDD1632  [3]
 LDCM0432  CL42 HEK-293T C286(1.04)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C286(1.33)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C286(1.30)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C87(1.36)  LDD1639  [3]
 LDCM0438  CL48 HEK-293T C87(0.79)  LDD1642  [3]
 LDCM0445  CL54 HEK-293T C286(1.04)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C286(1.39)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C286(1.34)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C87(1.16)  LDD1651  [3]
 LDCM0451  CL6 HEK-293T C286(1.04)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C87(1.08)  LDD1655  [3]
 LDCM0455  CL63 HEK-293T C87(1.32)  LDD1658  [3]
 LDCM0458  CL66 HEK-293T C286(1.00)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C286(1.35)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C286(1.14)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C87(1.16)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C286(1.35)  LDD1665  [3]
 LDCM0465  CL72 HEK-293T C87(1.07)  LDD1668  [3]
 LDCM0471  CL78 HEK-293T C286(1.04)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C286(1.38)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C286(1.07)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C286(1.05)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C87(1.08)  LDD1678  [3]
 LDCM0478  CL84 HEK-293T C87(1.10)  LDD1681  [3]
 LDCM0481  CL87 HEK-293T C87(1.16)  LDD1684  [3]
 LDCM0484  CL9 HEK-293T C87(1.09)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C286(0.99)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C286(1.18)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C286(1.11)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C87(1.22)  LDD1691  [3]
 LDCM0491  CL96 HEK-293T C87(1.07)  LDD1694  [3]
 LDCM0494  CL99 HEK-293T C87(1.12)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C87(1.26)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C87(1.08)  LDD1671  [3]
 LDCM0022  KB02 HEK-293T C87(0.96)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C87(1.03)  LDD1497  [3]
 LDCM0024  KB05 OVCAR-5 C505(1.52)  LDD3383  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402