Details of the Target

General Information of Target

Target ID LDTP17753
Target Name Magnesium transporter NIPA2 (NIPA2)
Gene Name NIPA2
Gene ID 81614
Synonyms
Magnesium transporter NIPA2; Non-imprinted in Prader-Willi/Angelman syndrome region protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLEASCGTATSEVPKPEKKTARDAEPSSETRPQEVEAEPRSGSGPEAEAEPLDFVVATE
REFEEVLAISGGIYGGLDYLPSRYHSWLRDPDRTVVLAKRNGGVIALESVNVIDAGETVL
VEGLRVAPWERGKGVAGLLQRFCSQLVKRQHPGVKVARLTRDDQLGPRELKKYRLITKQG
ILLVRFNASALLAGLGARLAALRTSGTFSPLPTEAVSEAGGDVARLLLSPSVQRDVLPGG
TIIQDWQPYRPSESNLRLLAAKGLEWRVDSRARPRVLTLCTRPFPIPHGGDGTWRYLNID
AFGSDGAQVQSQLLWHLQRQAPRLVGLNVMCQLFLEPQLWSQLADFCQVGLGLELVKGYT
EQYLLEADI
Target Bioclass
Transporter and channel
Family
NIPA family
Subcellular location
Cell membrane
Function Acts as a selective Mg(2+) transporter.
Uniprot ID
Q8N8Q9
Ensemble ID
ENST00000337451.8
HGNC ID
HGNC:17044

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER Deletion: p.G34AfsTer11 .
LNCaP clone FGC Deletion: p.G34AfsTer11 .
RKO Deletion: p.G34AfsTer11 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C340(3.60)  LDD0171  [1]
DBIA
 Probe Info  		C340(1.00)  LDD1512  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C340(3.60)  LDD0171  [1]
 LDCM0259  AC14 HEK-293T C340(1.00)  LDD1512  [2]
 LDCM0282  AC22 HEK-293T C340(0.99)  LDD1521  [2]
 LDCM0291  AC30 HEK-293T C340(1.03)  LDD1530  [2]
 LDCM0299  AC38 HEK-293T C340(0.94)  LDD1538  [2]
 LDCM0308  AC46 HEK-293T C340(1.09)  LDD1547  [2]
 LDCM0317  AC54 HEK-293T C340(1.14)  LDD1556  [2]
 LDCM0323  AC6 HEK-293T C340(0.99)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C340(0.93)  LDD1565  [2]
 LDCM0368  CL10 HEK-293T C340(0.98)  LDD1572  [2]
 LDCM0410  CL22 HEK-293T C340(1.15)  LDD1614  [2]
 LDCM0423  CL34 HEK-293T C340(1.03)  LDD1627  [2]
 LDCM0436  CL46 HEK-293T C340(1.02)  LDD1640  [2]
 LDCM0449  CL58 HEK-293T C340(1.18)  LDD1652  [2]
 LDCM0463  CL70 HEK-293T C340(0.97)  LDD1666  [2]
 LDCM0476  CL82 HEK-293T C340(1.09)  LDD1679  [2]
 LDCM0489  CL94 HEK-293T C340(1.10)  LDD1692  [2]
 LDCM0625  F8 Ramos C340(0.38)  LDD2187  [5]
 LDCM0572  Fragment10 Ramos C340(0.56)  LDD2189  [5]
 LDCM0573  Fragment11 Ramos C340(0.16)  LDD2190  [5]
 LDCM0574  Fragment12 Ramos C340(2.47)  LDD2191  [5]
 LDCM0580  Fragment21 Ramos C340(2.12)  LDD2195  [5]
 LDCM0582  Fragment23 Ramos C340(0.84)  LDD2196  [5]
 LDCM0578  Fragment27 Ramos C340(0.55)  LDD2197  [5]
 LDCM0586  Fragment28 Ramos C340(1.34)  LDD2198  [5]
 LDCM0588  Fragment30 Ramos C340(0.44)  LDD2199  [5]
 LDCM0589  Fragment31 Ramos C340(0.45)  LDD2200  [5]
 LDCM0590  Fragment32 Ramos C340(0.43)  LDD2201  [5]
 LDCM0468  Fragment33 Ramos C340(1.20)  LDD2202  [5]
 LDCM0596  Fragment38 Ramos C340(0.60)  LDD2203  [5]
 LDCM0566  Fragment4 Ramos C340(1.32)  LDD2184  [5]
 LDCM0614  Fragment56 Ramos C340(1.97)  LDD2205  [5]
 LDCM0569  Fragment7 Ramos C340(0.48)  LDD2186  [5]
 LDCM0571  Fragment9 Ramos C340(1.41)  LDD2188  [5]
 LDCM0023  KB03 Ramos C340(0.47)  LDD2183  [5]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578