Details of the Target

General Information of Target

Target ID LDTP17691
Target Name ELMO domain-containing protein 1 (ELMOD1)
Gene Name ELMOD1
Gene ID 55531
Synonyms
ELMO domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRTLSLHEITDLLETDDSIEASAIVIQPPENATAPVSDEESGDEEGGTINNLPGSLLHT
AAYLIQDGSDAESDSDDPSYAPKDDSPDEVPSTFTVQQPPPSRRRKMTKILCKWKKADLT
VQPVAGRVTAPPNDFFTVMRTPTEILELFLDDEVIELIVKYSNLYACSKGVHLGLTSSEF
KCFLGIIFLSGYVSVPRRRMFWEQRTDVHNVLVSAAMRRDRFETIFSNLHVADNANLDPV
DKFSKLRPLISKLNERCMKFVPNETYFSFDEFMVPYFGRHGCKQFIRGKPIRFGYKFWCG
ATCLGYICWFQPYQGKNPNTKHEEYGVGASLVLQFSEALTEAHPGQYHFVFNNFFTSIAL
LDKLSSMGHQATGTVRKDHIDRVPLESDVALKKKERGTFDYRIDGKGNIVCRWNDNSVVT
VASSGAGIHPLCLVSRYSQKLKKKIQVQQPNMIKVYNQFMGGVDRADENIDKYRASIRGK
KWYSSPLLFCFELVLQNAWQLHKTYDEKPVDFLEFRRRVVCHYLETHGHPPEPGQKGRPQ
KRNIDSRYDGINHVIVKQGKQTRCAECHKNTTFRCEKCDVALHVKCSVEYHTE
Target Bioclass
Other
Function Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.
Uniprot ID
Q8N336
Ensemble ID
ENST00000265840.12
HGNC ID
HGNC:25334

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH1703 SNV: p.E266Ter .
NCIH2170 SNV: p.P74H .
RL952 Insertion: p.T80NfsTer12 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C322(2.02)  LDD3404  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C322(0.79)  LDD1509  [2]
 LDCM0259  AC14 HEK-293T C322(0.92)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C322(0.97)  LDD1513  [2]
 LDCM0278  AC19 HEK-293T C322(0.73)  LDD1517  [2]
 LDCM0281  AC21 HEK-293T C322(1.04)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C322(1.05)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C322(1.36)  LDD1522  [2]
 LDCM0287  AC27 HEK-293T C322(0.91)  LDD1526  [2]
 LDCM0289  AC29 HEK-293T C322(1.05)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C322(0.79)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C322(1.56)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C322(1.05)  LDD1531  [2]
 LDCM0296  AC35 HEK-293T C322(1.00)  LDD1535  [2]
 LDCM0298  AC37 HEK-293T C322(0.98)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C322(0.92)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C322(0.86)  LDD1539  [2]
 LDCM0305  AC43 HEK-293T C322(0.85)  LDD1544  [2]
 LDCM0307  AC45 HEK-293T C322(1.21)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C322(1.27)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C322(0.94)  LDD1548  [2]
 LDCM0312  AC5 HEK-293T C322(1.21)  LDD1551  [2]
 LDCM0314  AC51 HEK-293T C322(0.94)  LDD1553  [2]
 LDCM0316  AC53 HEK-293T C322(0.94)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C322(0.80)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C322(1.42)  LDD1557  [2]
 LDCM0322  AC59 HEK-293T C322(0.87)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C322(1.04)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C322(0.93)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C322(1.22)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C322(0.97)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C322(0.96)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C322(0.95)  LDD1511  [2]
 LDCM0368  CL10 HEK-293T C322(1.25)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C322(1.59)  LDD1573  [2]
 LDCM0372  CL103 HEK-293T C322(0.78)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C322(1.23)  LDD1577  [2]
 LDCM0376  CL107 HEK-293T C322(0.89)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C322(1.08)  LDD1581  [2]
 LDCM0379  CL11 HEK-293T C322(0.96)  LDD1583  [2]
 LDCM0381  CL111 HEK-293T C322(0.86)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C322(1.17)  LDD1586  [2]
 LDCM0385  CL115 HEK-293T C322(0.90)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C322(0.85)  LDD1590  [2]
 LDCM0389  CL119 HEK-293T C322(1.29)  LDD1593  [2]
 LDCM0391  CL120 HEK-293T C322(1.09)  LDD1595  [2]
 LDCM0394  CL123 HEK-293T C322(1.10)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C322(1.07)  LDD1599  [2]
 LDCM0398  CL127 HEK-293T C322(0.91)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C322(0.98)  LDD1603  [2]
 LDCM0402  CL15 HEK-293T C322(0.97)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C322(0.92)  LDD1607  [2]
 LDCM0406  CL19 HEK-293T C322(0.89)  LDD1610  [2]
 LDCM0409  CL21 HEK-293T C322(2.05)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C322(1.01)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C322(0.97)  LDD1615  [2]
 LDCM0415  CL27 HEK-293T C322(0.71)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C322(0.98)  LDD1620  [2]
 LDCM0418  CL3 HEK-293T C322(0.83)  LDD1622  [2]
 LDCM0420  CL31 HEK-293T C322(1.05)  LDD1624  [2]
 LDCM0422  CL33 HEK-293T C322(1.95)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C322(1.00)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C322(0.82)  LDD1628  [2]
 LDCM0428  CL39 HEK-293T C322(1.38)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C322(1.58)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C322(0.85)  LDD1634  [2]
 LDCM0433  CL43 HEK-293T C322(0.91)  LDD1637  [2]
 LDCM0435  CL45 HEK-293T C322(1.03)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C322(1.54)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C322(1.19)  LDD1641  [2]
 LDCM0443  CL52 HEK-293T C322(1.13)  LDD1646  [2]
 LDCM0446  CL55 HEK-293T C322(0.82)  LDD1649  [2]
 LDCM0448  CL57 HEK-293T C322(0.81)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C322(0.88)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C322(0.94)  LDD1653  [2]
 LDCM0455  CL63 HEK-293T C322(0.66)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C322(1.65)  LDD1659  [2]
 LDCM0459  CL67 HEK-293T C322(0.94)  LDD1662  [2]
 LDCM0461  CL69 HEK-293T C322(0.91)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C322(0.83)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C322(0.86)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C322(1.15)  LDD1667  [2]
 LDCM0469  CL76 HEK-293T C322(1.00)  LDD1672  [2]
 LDCM0472  CL79 HEK-293T C322(0.87)  LDD1675  [2]
 LDCM0475  CL81 HEK-293T C322(0.88)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C322(0.74)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C322(0.96)  LDD1680  [2]
 LDCM0481  CL87 HEK-293T C322(0.90)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C322(1.11)  LDD1685  [2]
 LDCM0484  CL9 HEK-293T C322(0.94)  LDD1687  [2]
 LDCM0486  CL91 HEK-293T C322(0.85)  LDD1689  [2]
 LDCM0488  CL93 HEK-293T C322(1.55)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C322(1.36)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C322(1.67)  LDD1693  [2]
 LDCM0494  CL99 HEK-293T C322(0.97)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C322(1.44)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C322(1.47)  LDD1671  [2]
 LDCM0022  KB02 KNS-42 C322(2.93)  LDD2425  [1]
 LDCM0023  KB03 KNS-42 C322(2.88)  LDD2842  [1]
 LDCM0024  KB05 SJRH30 C322(2.02)  LDD3404  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402