Details of the Target

General Information of Target

Target ID LDTP17616
Target Name Cartilage intermediate layer protein 2 (CILP2)
Gene Name CILP2
Gene ID 148113
Synonyms
Cartilage intermediate layer protein 2; CILP-2) [Cleaved into: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAPGRGPLGLRLMMPGRRGALREPGGCGSCLGVALALLLLLLPACCPVRAQNDTEPIVL
EGKCLVVCDSSPSADGAVTSSLGISVRSGSAKVAFSATRSTNHEPSEMSNRTMTIYFDQV
LVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQVSLMQNGYPVISAFAGDQDVT
REAASNGVLLLMEREDKVHLKLERGNLMGGWKYSTFSGFLVFPL
Target Bioclass
Immunoglobulin
Subcellular location
Secreted, extracellular space, extracellular matrix
Function May play a role in cartilage scaffolding.
Uniprot ID
Q8IUL8
Ensemble ID
ENST00000291495.5
HGNC ID
HGNC:24213

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C415(0.77)  LDD2140  [1]
DBIA
 Probe Info  		C430(0.73)  LDD1509  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C430(0.73)  LDD1509  [2]
 LDCM0278  AC19 HEK-293T C430(0.74)  LDD1517  [2]
 LDCM0284  AC24 HEK-293T C430(0.87)  LDD1523  [2]
 LDCM0287  AC27 HEK-293T C430(0.89)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C430(1.30)  LDD1529  [2]
 LDCM0293  AC32 HEK-293T C430(0.89)  LDD1532  [2]
 LDCM0296  AC35 HEK-293T C430(0.95)  LDD1535  [2]
 LDCM0302  AC40 HEK-293T C430(1.02)  LDD1541  [2]
 LDCM0305  AC43 HEK-293T C430(0.82)  LDD1544  [2]
 LDCM0310  AC48 HEK-293T C430(0.69)  LDD1549  [2]
 LDCM0314  AC51 HEK-293T C430(0.84)  LDD1553  [2]
 LDCM0319  AC56 HEK-293T C430(0.73)  LDD1558  [2]
 LDCM0322  AC59 HEK-293T C430(0.82)  LDD1561  [2]
 LDCM0328  AC64 HEK-293T C430(0.92)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C430(1.18)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C430(0.83)  LDD1514  [2]
 LDCM0020  ARS-1620 HCC44 C270(1.06)  LDD2171  [3]
 LDCM0369  CL100 HEK-293T C252(1.10)  LDD1573  [2]
 LDCM0373  CL104 HEK-293T C252(1.09)  LDD1577  [2]
 LDCM0377  CL108 HEK-293T C252(1.24)  LDD1581  [2]
 LDCM0382  CL112 HEK-293T C252(1.00)  LDD1586  [2]
 LDCM0386  CL116 HEK-293T C252(0.94)  LDD1590  [2]
 LDCM0390  CL12 HEK-293T C430(1.46)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C252(1.24)  LDD1595  [2]
 LDCM0395  CL124 HEK-293T C252(1.07)  LDD1599  [2]
 LDCM0399  CL128 HEK-293T C252(0.96)  LDD1603  [2]
 LDCM0403  CL16 HEK-293T C252(1.05)  LDD1607  [2]
 LDCM0406  CL19 HEK-293T C430(0.87)  LDD1610  [2]
 LDCM0412  CL24 HEK-293T C430(1.09)  LDD1616  [2]
 LDCM0416  CL28 HEK-293T C252(1.11)  LDD1620  [2]
 LDCM0420  CL31 HEK-293T C430(0.80)  LDD1624  [2]
 LDCM0425  CL36 HEK-293T C430(0.95)  LDD1629  [2]
 LDCM0429  CL4 HEK-293T C252(1.05)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C252(0.98)  LDD1634  [2]
 LDCM0433  CL43 HEK-293T C430(0.98)  LDD1637  [2]
 LDCM0438  CL48 HEK-293T C430(1.11)  LDD1642  [2]
 LDCM0443  CL52 HEK-293T C252(1.04)  LDD1646  [2]
 LDCM0446  CL55 HEK-293T C430(0.99)  LDD1649  [2]
 LDCM0452  CL60 HEK-293T C430(1.02)  LDD1655  [2]
 LDCM0456  CL64 HEK-293T C252(1.04)  LDD1659  [2]
 LDCM0459  CL67 HEK-293T C430(1.08)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C430(1.38)  LDD1665  [2]
 LDCM0465  CL72 HEK-293T C430(1.05)  LDD1668  [2]
 LDCM0469  CL76 HEK-293T C252(1.07)  LDD1672  [2]
 LDCM0472  CL79 HEK-293T C430(0.82)  LDD1675  [2]
 LDCM0478  CL84 HEK-293T C430(0.90)  LDD1681  [2]
 LDCM0482  CL88 HEK-293T C252(1.00)  LDD1685  [2]
 LDCM0486  CL91 HEK-293T C430(0.88)  LDD1689  [2]
 LDCM0491  CL96 HEK-293T C430(1.02)  LDD1694  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C415(0.77)  LDD2140  [1]
 LDCM0021  THZ1 HCT 116 C270(1.06)  LDD2173  [3]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.