Details of the Target

General Information of Target

Target ID LDTP17536
Target Name Lysosomal cholesterol signaling protein (GPR155)
Gene Name GPR155
Gene ID 151556
Synonyms
PGR22; Lysosomal cholesterol signaling protein; LYCHOS; G-protein coupled receptor PGR22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSETDHIASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHN
NRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILV
ELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRV
PNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKR
TETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKK
CEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRL
HQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKL
TQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAK
IKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKV
KTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNA
QLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELA
CRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSM
GSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIE
FMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPA
DNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT
Target Bioclass
Transporter and channel
Subcellular location
Membrane
Function
Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway. Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disrupt interaction between the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition.
Uniprot ID
Q7Z3F1
Ensemble ID
ENST00000295500.8
HGNC ID
HGNC:22951

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C629(1.70)  LDD3377  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C629(1.09)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C629(1.06)  LDD1508  [2]
 LDCM0259  AC14 HEK-293T C629(0.92)  LDD1512  [2]
 LDCM0276  AC17 HEK-293T C629(1.12)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C629(0.90)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C629(0.98)  LDD1518  [2]
 LDCM0281  AC21 HEK-293T C629(0.99)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C629(0.97)  LDD1521  [2]
 LDCM0284  AC24 HEK-293T C629(1.01)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C629(1.16)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C629(0.89)  LDD1525  [2]
 LDCM0289  AC29 HEK-293T C629(1.08)  LDD1528  [2]
 LDCM0291  AC30 HEK-293T C629(1.03)  LDD1530  [2]
 LDCM0293  AC32 HEK-293T C629(1.07)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C629(1.09)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C629(1.09)  LDD1534  [2]
 LDCM0298  AC37 HEK-293T C629(0.99)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C629(0.95)  LDD1538  [2]
 LDCM0302  AC40 HEK-293T C629(1.07)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C629(1.22)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C629(1.01)  LDD1543  [2]
 LDCM0307  AC45 HEK-293T C629(1.01)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C629(0.95)  LDD1547  [2]
 LDCM0310  AC48 HEK-293T C629(1.21)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C629(1.18)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C629(1.00)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C629(1.04)  LDD1552  [2]
 LDCM0316  AC53 HEK-293T C629(1.01)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C629(1.12)  LDD1556  [2]
 LDCM0319  AC56 HEK-293T C629(1.02)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C629(1.12)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C629(0.86)  LDD1560  [2]
 LDCM0323  AC6 HEK-293T C629(0.94)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C629(1.06)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C629(0.99)  LDD1565  [2]
 LDCM0328  AC64 HEK-293T C629(1.01)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C629(1.08)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C629(1.03)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C629(1.05)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C629(1.16)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C629(0.93)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C629(1.19)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C629(0.95)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C629(1.16)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C629(1.06)  LDD1576  [2]
 LDCM0374  CL105 HEK-293T C629(0.98)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C629(1.04)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C629(1.11)  LDD1580  [2]
 LDCM0378  CL109 HEK-293T C629(0.98)  LDD1582  [2]
 LDCM0380  CL110 HEK-293T C629(1.01)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C629(1.09)  LDD1585  [2]
 LDCM0383  CL113 HEK-293T C629(0.97)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C629(1.25)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C629(1.08)  LDD1589  [2]
 LDCM0387  CL117 HEK-293T C629(1.08)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C629(1.16)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C629(1.10)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C629(1.06)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C629(0.90)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C629(1.12)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C629(1.02)  LDD1598  [2]
 LDCM0396  CL125 HEK-293T C629(0.95)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C629(1.03)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C629(0.99)  LDD1602  [2]
 LDCM0400  CL13 HEK-293T C629(0.88)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C629(1.03)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C629(1.09)  LDD1606  [2]
 LDCM0404  CL17 HEK-293T C629(1.09)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C629(1.04)  LDD1609  [2]
 LDCM0407  CL2 HEK-293T C629(0.98)  LDD1611  [2]
 LDCM0409  CL21 HEK-293T C629(1.02)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C629(0.98)  LDD1614  [2]
 LDCM0412  CL24 HEK-293T C629(0.99)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C629(0.92)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C629(1.07)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C629(1.03)  LDD1619  [2]
 LDCM0417  CL29 HEK-293T C629(1.17)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C629(0.95)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C629(0.92)  LDD1623  [2]
 LDCM0422  CL33 HEK-293T C629(1.02)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C629(0.92)  LDD1627  [2]
 LDCM0425  CL36 HEK-293T C629(1.00)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C629(0.74)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C629(0.94)  LDD1632  [2]
 LDCM0431  CL41 HEK-293T C629(1.11)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C629(0.87)  LDD1636  [2]
 LDCM0435  CL45 HEK-293T C629(1.05)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C629(0.97)  LDD1640  [2]
 LDCM0438  CL48 HEK-293T C629(1.01)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C629(0.86)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C629(1.02)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C629(1.02)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C629(1.15)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C629(1.23)  LDD1648  [2]
 LDCM0448  CL57 HEK-293T C629(1.15)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C629(1.01)  LDD1652  [2]
 LDCM0451  CL6 HEK-293T C629(0.90)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C629(1.20)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C629(0.88)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C629(1.04)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C629(1.05)  LDD1658  [2]
 LDCM0457  CL65 HEK-293T C629(1.02)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C629(0.97)  LDD1661  [2]
 LDCM0461  CL69 HEK-293T C629(0.97)  LDD1664  [2]
 LDCM0463  CL70 HEK-293T C629(0.96)  LDD1666  [2]
 LDCM0465  CL72 HEK-293T C629(1.08)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C629(0.86)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C629(1.08)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C629(1.21)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C629(0.83)  LDD1674  [2]
 LDCM0475  CL81 HEK-293T C629(1.11)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C629(0.95)  LDD1679  [2]
 LDCM0478  CL84 HEK-293T C629(0.98)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C629(0.92)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C629(0.91)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C629(0.99)  LDD1684  [2]
 LDCM0483  CL89 HEK-293T C629(1.08)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C629(0.96)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C629(0.97)  LDD1688  [2]
 LDCM0488  CL93 HEK-293T C629(0.98)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C629(1.08)  LDD1692  [2]
 LDCM0491  CL96 HEK-293T C629(1.09)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C629(0.96)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C629(0.94)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C629(0.97)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C629(1.04)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C629(1.03)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C629(0.97)  LDD1631  [2]
 LDCM0022  KB02 A101D C751(1.65); C629(2.13)  LDD2250  [1]
 LDCM0023  KB03 A101D C751(2.45); C629(3.56)  LDD2667  [1]
 LDCM0024  KB05 OPM-2 C629(1.70)  LDD3377  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402