Details of the Target

General Information of Target

Target ID LDTP17245
Target Name Microtubule cross-linking factor 3 (MTCL3)
Gene Name MTCL3
Synonyms
C6orf174; SOGA3; Microtubule cross-linking factor 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKQEDNQGVCAHQDSEDKGMGSDFEDSEDREGDPEEREMGSNPHDTNKREGHPEPEMGSN
PQDSRHREAVPDICTEGQLSEEEGVSVRGEEDDQSGVADMAMFPGLSESDSISRSLREDD
DESAGENRLEEEEEQPAPPVLPWRRHLSLGSRHRGDKPAHRRFHRLHHPMAVDLGELDSL
VASIMDAPTICPDCGESFSPGAAFLQHQRIHRLAEAAAAASLEPFGLAGECDAMVGMMGV
GVAGGFGAGPPLARPPREKPFRCGECGKGFSRNTYLTNHLRLHTGERPNLCADCGKSFSW
RADLLKHRRLHTGEKPYPCPECGEAFSLSSHLLSHRRAHAAASGAGAAALRPFACGECGK
GFVRRSHLANHQRIHTGEKPHGCGECGKRFSWRSDLVKHQRVHTGEKPYMCSECGETFSV
SSHLFTHKRTHSGERPYVCRECGKGFGRNSHLVNHLRVHTGEKPFRCGQCEKRFSDFSTL
TQHQRTHTGEKPYTCIECGKSFIQSSHLIRHRRIHTGNKPHKCAGCGKGFRYKTHLAQHQ
KLHLC
Target Bioclass
Other
Family
SOGA family
Subcellular location
Membrane
Uniprot ID
Q5TF21
Ensemble ID
ENST00000525778.6
HGNC ID
HGNC:21494

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0403  [1]
DBIA
 Probe Info  		C527(10.56); C254(2.61)  LDD3340  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C527(1.12)  LDD1509  [3]
 LDCM0270  AC15 HEK-293T C527(0.93)  LDD1513  [3]
 LDCM0278  AC19 HEK-293T C527(1.02)  LDD1517  [3]
 LDCM0283  AC23 HEK-293T C527(0.93)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C527(1.13)  LDD1523  [3]
 LDCM0287  AC27 HEK-293T C527(1.07)  LDD1526  [3]
 LDCM0290  AC3 HEK-293T C527(1.02)  LDD1529  [3]
 LDCM0292  AC31 HEK-293T C527(1.01)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C527(0.91)  LDD1532  [3]
 LDCM0296  AC35 HEK-293T C527(0.98)  LDD1535  [3]
 LDCM0300  AC39 HEK-293T C527(1.01)  LDD1539  [3]
 LDCM0302  AC40 HEK-293T C527(0.99)  LDD1541  [3]
 LDCM0305  AC43 HEK-293T C527(1.00)  LDD1544  [3]
 LDCM0309  AC47 HEK-293T C527(0.95)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C527(0.96)  LDD1549  [3]
 LDCM0314  AC51 HEK-293T C527(1.09)  LDD1553  [3]
 LDCM0318  AC55 HEK-293T C527(0.95)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C527(0.92)  LDD1558  [3]
 LDCM0322  AC59 HEK-293T C527(0.96)  LDD1561  [3]
 LDCM0327  AC63 HEK-293T C527(0.96)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C527(1.00)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C527(1.02)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C527(0.99)  LDD1569  [3]
 LDCM0275  AKOS034007705 HEK-293T C527(1.10)  LDD1514  [3]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0379  CL11 HEK-293T C527(0.87)  LDD1583  [3]
 LDCM0390  CL12 HEK-293T C527(0.94)  LDD1594  [3]
 LDCM0406  CL19 HEK-293T C527(1.03)  LDD1610  [3]
 LDCM0411  CL23 HEK-293T C527(0.90)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C527(0.92)  LDD1616  [3]
 LDCM0420  CL31 HEK-293T C527(0.97)  LDD1624  [3]
 LDCM0424  CL35 HEK-293T C527(0.88)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C527(0.90)  LDD1629  [3]
 LDCM0433  CL43 HEK-293T C527(0.99)  LDD1637  [3]
 LDCM0437  CL47 HEK-293T C527(0.92)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C527(0.95)  LDD1642  [3]
 LDCM0446  CL55 HEK-293T C527(1.00)  LDD1649  [3]
 LDCM0450  CL59 HEK-293T C527(0.95)  LDD1653  [3]
 LDCM0452  CL60 HEK-293T C527(0.90)  LDD1655  [3]
 LDCM0459  CL67 HEK-293T C527(1.03)  LDD1662  [3]
 LDCM0462  CL7 HEK-293T C527(0.96)  LDD1665  [3]
 LDCM0464  CL71 HEK-293T C527(0.98)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C527(0.91)  LDD1668  [3]
 LDCM0472  CL79 HEK-293T C527(1.01)  LDD1675  [3]
 LDCM0477  CL83 HEK-293T C527(0.93)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C527(0.86)  LDD1681  [3]
 LDCM0486  CL91 HEK-293T C527(0.93)  LDD1689  [3]
 LDCM0490  CL95 HEK-293T C527(0.92)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C527(0.86)  LDD1694  [3]
 LDCM0022  KB02 42-MG-BA C527(3.76)  LDD2244  [2]
 LDCM0023  KB03 42-MG-BA C527(2.04)  LDD2661  [2]
 LDCM0024  KB05 NB1 C527(10.56); C254(2.61)  LDD3340  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402