Details of the Target

General Information of Target

Target ID LDTP17010
Target Name Echinoderm microtubule-associated protein-like 5 (EML5)
Gene Name EML5
Gene ID 161436
Synonyms
Echinoderm microtubule-associated protein-like 5; EMAP-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPLEFRDVAIEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFLGIVVTKPDLITCLEQGK
KPFTVKRHEMIAKSPVMCFHFAQDLCPEQSLKDSFQKVIVTRYEKREYGNLELKKGCESV
DEGKVHKRGYNGLNQCLTATQSKVFQCDTYVKVSHIFSNSNRHKIRDTGKKPFKCIECGK
AFNQSSTLATHKKIHTGEITCKCEECGKAFNRSSHLTSHKRIHTGEKRYKCEDCGKELKY
SSTLTAHKRIHTGEKRYKCEDCGKELKYSSTLTAHKRIHTGEKPYKCDKCGRAFISSSIL
YVHKISHTEEKPYKCEECGKAFKLSSILSTHKRIHTGEKPYKCEECGKAFRRSLVLRTHK
RIHTGEKPYKCDKCGKAFISSSLLYKHKISHSEKKPYKCEECGKAFKRSSTLTIHKISHT
EEKPYKCQECDKVFKRSSALSTHKIIHSGEKPYKCEECGKAFKRSSNLTTHKISHTEEKL
YKCQECDKAFKYSSALSTHKIIHSGENPYKCEECGKAFKRSSVLSKHKIIHTGAKPYKCE
ECGKAFKRSSQLTSHKISHTGEKPYKCEECGKAFNLSSDLNTHKRIHIGQKAYIVKNMAN
L
Target Bioclass
Other
Family
WD repeat EMAP family
Subcellular location
Cytoplasm, cytoskeleton
Function May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
Uniprot ID
Q05BV3
Ensemble ID
ENST00000380664.9
HGNC ID
HGNC:18197

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C363(1.79); C1972(1.97)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C1920(0.99)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C1920(1.10)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C1920(0.98)  LDD1513  [2]
 LDCM0280  AC20 HEK-293T C1920(0.85)  LDD1519  [2]
 LDCM0282  AC22 HEK-293T C1920(0.97)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C1920(0.94)  LDD1522  [2]
 LDCM0288  AC28 HEK-293T C1920(1.04)  LDD1527  [2]
 LDCM0291  AC30 HEK-293T C1920(1.08)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C1920(0.92)  LDD1531  [2]
 LDCM0297  AC36 HEK-293T C1920(1.00)  LDD1536  [2]
 LDCM0299  AC38 HEK-293T C1920(1.12)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C1920(1.11)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C1920(0.91)  LDD1540  [2]
 LDCM0306  AC44 HEK-293T C1920(1.08)  LDD1545  [2]
 LDCM0308  AC46 HEK-293T C1920(1.14)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C1920(0.99)  LDD1548  [2]
 LDCM0315  AC52 HEK-293T C1920(0.98)  LDD1554  [2]
 LDCM0317  AC54 HEK-293T C1920(1.10)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C1920(1.01)  LDD1557  [2]
 LDCM0323  AC6 HEK-293T C1920(0.97)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C1920(1.04)  LDD1563  [2]
 LDCM0326  AC62 HEK-293T C1920(1.06)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C1920(0.99)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C1920(0.95)  LDD1568  [2]
 LDCM0367  CL1 HEK-293T C1920(1.01)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C1920(1.38)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C1920(0.99)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C1920(1.06)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C1920(0.98)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C1920(1.04)  LDD1583  [2]
 LDCM0383  CL113 HEK-293T C1920(1.10)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C1920(1.12)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C1920(1.00)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C1920(0.99)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C1920(1.01)  LDD1604  [2]
 LDCM0408  CL20 HEK-293T C1920(1.04)  LDD1612  [2]
 LDCM0410  CL22 HEK-293T C1920(1.11)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C1920(1.00)  LDD1615  [2]
 LDCM0413  CL25 HEK-293T C1920(1.01)  LDD1617  [2]
 LDCM0421  CL32 HEK-293T C1920(1.04)  LDD1625  [2]
 LDCM0423  CL34 HEK-293T C1920(0.99)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C1920(0.98)  LDD1628  [2]
 LDCM0426  CL37 HEK-293T C1920(0.96)  LDD1630  [2]
 LDCM0434  CL44 HEK-293T C1920(0.67)  LDD1638  [2]
 LDCM0436  CL46 HEK-293T C1920(1.02)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C1920(1.12)  LDD1641  [2]
 LDCM0439  CL49 HEK-293T C1920(1.00)  LDD1643  [2]
 LDCM0447  CL56 HEK-293T C1920(0.98)  LDD1650  [2]
 LDCM0449  CL58 HEK-293T C1920(1.12)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C1920(0.99)  LDD1653  [2]
 LDCM0453  CL61 HEK-293T C1920(1.07)  LDD1656  [2]
 LDCM0460  CL68 HEK-293T C1920(0.88)  LDD1663  [2]
 LDCM0463  CL70 HEK-293T C1920(1.15)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C1920(1.09)  LDD1667  [2]
 LDCM0466  CL73 HEK-293T C1920(0.83)  LDD1669  [2]
 LDCM0473  CL8 HEK-293T C1920(0.65)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C1920(0.96)  LDD1677  [2]
 LDCM0476  CL82 HEK-293T C1920(1.22)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C1920(1.07)  LDD1680  [2]
 LDCM0479  CL85 HEK-293T C1920(1.28)  LDD1682  [2]
 LDCM0487  CL92 HEK-293T C1920(1.25)  LDD1690  [2]
 LDCM0489  CL94 HEK-293T C1920(1.24)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C1920(0.78)  LDD1693  [2]
 LDCM0492  CL97 HEK-293T C1920(0.88)  LDD1695  [2]
 LDCM0022  KB02 HEK-293T C1920(1.00)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C1920(0.97)  LDD1497  [2]
 LDCM0024  KB05 NB1 C363(1.79); C1972(1.97)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402