Details of the Target

General Information of Target

Target ID LDTP16842
Target Name Neurexophilin-4 (NXPH4)
Gene Name NXPH4
Gene ID 11247
Synonyms
NPH4; Neurexophilin-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQLTRCCFVFLVQGSLYLVICGQDDGPPGSEDPERDDHEGQPRPRVPRKRGHISPKSRPM
ANSTLLGLLAPPGEAWGILGQPPNRPNHSPPPSAKVKKIFGWGDFYSNIKTVALNLLVTG
KIVDHGNGTFSVHFQHNATGQGNISISLVPPSKAVEFHQEQQIFIEAKASKIFNCRMEWE
KVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKVVCVYIAFYSTDYRLVQKVCPDY
NYHSDTPYYPSG
Target Bioclass
Other
Family
Neurexophilin family
Subcellular location
Secreted
Function May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
Uniprot ID
O95158
Ensemble ID
ENST00000349394.6
HGNC ID
HGNC:8078

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C233(6.07)  LDD3342  [1]
IA-alkyne
 Probe Info  		C56(0.00); C744(0.00)  LDD0161  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C233(1.12)  LDD1507  [4]
 LDCM0226  AC11 HEK-293T C233(1.08)  LDD1509  [4]
 LDCM0259  AC14 HEK-293T C233(1.13)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C233(1.26)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C233(1.05)  LDD1515  [4]
 LDCM0278  AC19 HEK-293T C233(1.10)  LDD1517  [4]
 LDCM0282  AC22 HEK-293T C233(1.08)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C233(1.06)  LDD1522  [4]
 LDCM0285  AC25 HEK-293T C233(1.06)  LDD1524  [4]
 LDCM0287  AC27 HEK-293T C233(1.19)  LDD1526  [4]
 LDCM0290  AC3 HEK-293T C233(1.14)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C233(1.17)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C233(0.99)  LDD1531  [4]
 LDCM0294  AC33 HEK-293T C233(0.99)  LDD1533  [4]
 LDCM0296  AC35 HEK-293T C233(1.18)  LDD1535  [4]
 LDCM0299  AC38 HEK-293T C233(1.11)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C233(1.03)  LDD1539  [4]
 LDCM0303  AC41 HEK-293T C233(1.04)  LDD1542  [4]
 LDCM0305  AC43 HEK-293T C233(1.00)  LDD1544  [4]
 LDCM0308  AC46 HEK-293T C233(1.11)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C233(1.32)  LDD1548  [4]
 LDCM0311  AC49 HEK-293T C233(1.01)  LDD1550  [4]
 LDCM0314  AC51 HEK-293T C233(1.08)  LDD1553  [4]
 LDCM0317  AC54 HEK-293T C233(1.18)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C233(1.09)  LDD1557  [4]
 LDCM0320  AC57 HEK-293T C233(1.05)  LDD1559  [4]
 LDCM0322  AC59 HEK-293T C233(1.12)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C233(1.17)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C233(1.18)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C233(1.10)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C233(1.06)  LDD1568  [4]
 LDCM0356  AKOS034007680 HEK-293T C233(0.95)  LDD1570  [4]
 LDCM0367  CL1 HEK-293T C233(0.93)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C233(1.12)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C233(0.94)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C233(0.97)  LDD1574  [4]
 LDCM0372  CL103 HEK-293T C233(1.06)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C233(0.95)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C233(0.91)  LDD1578  [4]
 LDCM0376  CL107 HEK-293T C233(1.09)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C233(0.99)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C233(0.92)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C233(1.05)  LDD1583  [4]
 LDCM0381  CL111 HEK-293T C233(1.10)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C233(1.01)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C233(1.00)  LDD1587  [4]
 LDCM0385  CL115 HEK-293T C233(1.10)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C233(0.98)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C233(0.89)  LDD1591  [4]
 LDCM0389  CL119 HEK-293T C233(1.06)  LDD1593  [4]
 LDCM0391  CL120 HEK-293T C233(1.05)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C233(0.92)  LDD1596  [4]
 LDCM0394  CL123 HEK-293T C233(1.05)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C233(1.06)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C233(1.04)  LDD1600  [4]
 LDCM0398  CL127 HEK-293T C233(1.03)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C233(0.93)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C233(1.07)  LDD1604  [4]
 LDCM0402  CL15 HEK-293T C233(1.10)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C233(0.90)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C233(1.00)  LDD1608  [4]
 LDCM0406  CL19 HEK-293T C233(1.00)  LDD1610  [4]
 LDCM0410  CL22 HEK-293T C233(1.03)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C233(1.11)  LDD1615  [4]
 LDCM0413  CL25 HEK-293T C233(0.98)  LDD1617  [4]
 LDCM0415  CL27 HEK-293T C233(1.05)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C233(1.00)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C233(0.96)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C233(0.98)  LDD1622  [4]
 LDCM0420  CL31 HEK-293T C233(1.04)  LDD1624  [4]
 LDCM0423  CL34 HEK-293T C233(0.98)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C233(1.01)  LDD1628  [4]
 LDCM0426  CL37 HEK-293T C233(0.95)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C233(1.03)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C233(0.89)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C233(0.93)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C233(0.96)  LDD1635  [4]
 LDCM0433  CL43 HEK-293T C233(0.99)  LDD1637  [4]
 LDCM0436  CL46 HEK-293T C233(1.01)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C233(1.06)  LDD1641  [4]
 LDCM0439  CL49 HEK-293T C233(1.10)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C233(1.00)  LDD1644  [4]
 LDCM0443  CL52 HEK-293T C233(1.02)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C233(1.02)  LDD1647  [4]
 LDCM0446  CL55 HEK-293T C233(1.07)  LDD1649  [4]
 LDCM0449  CL58 HEK-293T C233(1.11)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C233(1.10)  LDD1653  [4]
 LDCM0453  CL61 HEK-293T C233(1.15)  LDD1656  [4]
 LDCM0455  CL63 HEK-293T C233(1.05)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C233(0.96)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C233(1.02)  LDD1660  [4]
 LDCM0459  CL67 HEK-293T C233(1.05)  LDD1662  [4]
 LDCM0462  CL7 HEK-293T C233(1.17)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C233(1.00)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C233(1.19)  LDD1667  [4]
 LDCM0466  CL73 HEK-293T C233(0.92)  LDD1669  [4]
 LDCM0469  CL76 HEK-293T C233(1.02)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C233(1.08)  LDD1673  [4]
 LDCM0472  CL79 HEK-293T C233(1.01)  LDD1675  [4]
 LDCM0476  CL82 HEK-293T C233(1.01)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C233(1.12)  LDD1680  [4]
 LDCM0479  CL85 HEK-293T C233(0.99)  LDD1682  [4]
 LDCM0481  CL87 HEK-293T C233(1.08)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C233(0.97)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C233(1.02)  LDD1686  [4]
 LDCM0486  CL91 HEK-293T C233(1.02)  LDD1689  [4]
 LDCM0489  CL94 HEK-293T C233(1.09)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C233(1.22)  LDD1693  [4]
 LDCM0492  CL97 HEK-293T C233(1.12)  LDD1695  [4]
 LDCM0494  CL99 HEK-293T C233(1.01)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C233(1.10)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C233(1.01)  LDD1671  [4]
 LDCM0022  KB02 22RV1 C233(2.84)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C233(4.68)  LDD2660  [1]
 LDCM0024  KB05 NCI-H1155 C233(6.07)  LDD3342  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402