Details of the Target

General Information of Target

Target ID LDTP16605
Target Name Embryonic polyadenylate-binding protein 2 (PABPN1L)
Gene Name PABPN1L
Gene ID 390748
Synonyms
EPABP2; PABPNL1; Embryonic polyadenylate-binding protein 2; Embryonic poly(A)-binding protein 2; ePABP-2; ePABP2; Embryonic poly(A)-binding protein type II; Poly(A)-binding protein nuclear-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLMGHGKVEMLLYAVPLLKAPNCLSSSMQLPHGGGRHQELVRFRDVAVVFSPEEWDHLT
PEQRNLYKDVMLDNCKYLASLGNWTYKAHVMSSLKQGKEPWMMEREVTGDPCPACQPALA
TFRALNESGNAFRQSFHHGEYRTHRTFVQHYECDDCGMAFGHVSQLTGHQKIHKVGETHE
YGENTRGFRHRSSFTMLQRICTLYKHFECNQCGETFNRPSKVIQHQSMHSGLKPYKCDVC
QKAFRFLSSLSIHQRFHVGNRVNLTRHQKTHTQRKPFSCNFCGKTFHRFSEKTQHLLIHT
RKKYYTCNYCKKEFNPYSKFILHQRTHTGEKPHKCDVCEKSFKSISNLNKHQKTHTGEKP
FSCNECKKTFAQRTDLARHQQIHTGKKSFICSSCKKTFVRLSDLTQHKGTHTGERPYQCT
TCEKAFKYRSNFTKHQKTHSIGRPFACNECGKTYRLNWELNQHKKIHTGEKPYECGECGK
RFNNNSNLNKHKKIHTGEKHFVCNQCGKAFSLNSKLSRHQRTHNKKENSSKSVSNLNKHQ
KTHAGEKPFPCNECKKAFAQRMDLARHQQIHTGRKPFICSSCKKTFVRLSDLTQHKGTHT
GERPYQCTTCEKAFKYQSNFTKHQKTHSIGRPFTCNECGKTFRLNWKLNQHKKIHTGEKP
YECGECGKCFNNNSNLSKHKKIHTGEKHFVCNQCGKAFSLNSKLSRHQITHNKKKP
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Binds the poly(A) tail of mRNA.
Uniprot ID
A6NDY0
Ensemble ID
ENST00000411789.6
HGNC ID
HGNC:37237

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
RBE SNV: p.T20M .
REC1 Deletion: p.D233TfsTer53 .
TOV21G SNV: p.P249T .
YSCCC SNV: p.W33Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K182(10.00)  LDD0277  [1]
BTD
 Probe Info  		C180(1.70)  LDD1700  [2]
AHL-Pu-1
 Probe Info  		C180(2.16)  LDD0169  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
PF-06672131
 Probe Info  		N.A.  LDD0152  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C180(0.95)  LDD2152  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C180(2.16)  LDD0169  [3]
 LDCM0498  BS-3668 MDA-MB-231 C180(0.90)  LDD2091  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C180(1.01)  LDD1702  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C180(1.06)  LDD2089  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C180(1.03)  LDD2093  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C180(1.21)  LDD2098  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C180(1.14)  LDD2105  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C180(0.17)  LDD2118  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C180(2.19)  LDD2119  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C180(0.75)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C180(0.95)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C180(1.08)  LDD2129  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C180(1.02)  LDD2133  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C180(1.14)  LDD2135  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C180(1.70)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C180(0.73)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C180(2.11)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C180(0.80)  LDD2146  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C180(0.22)  LDD2149  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264