Details of the Target

General Information of Target

Target ID LDTP16185
Target Name THAP domain-containing protein 10 (THAP10)
Gene Name THAP10
Gene ID 56906
Synonyms
THAP domain-containing protein 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPD
TSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLA
AFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAH
LETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAG
VAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVH
QEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGA
LWARTGGGGEAAAYNNKLVARHVPQIPKPAVLATGPSVPSTKEELTLEHFQMDALGELSD
GRAGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVIVQPGK
TRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLINVVVISVAIVIA
LPLTLLVCCSALQKRCRKCFNKDSTEATVTYVNLERLGYSEDGLEELSRHSVSEADRLLS
ARSSVDFQAFGVKGGRRINEYFC
Target Bioclass
Transcription factor
Uniprot ID
Q9P2Z0
Ensemble ID
ENST00000249861.9
HGNC ID
HGNC:23193

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K199(4.05)  LDD0277  [1]
ONAyne
 Probe Info  		K199(10.00)  LDD0275  [1]
DBIA
 Probe Info  		C130(1.39)  LDD3323  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C130(1.28)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C130(1.28)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C130(0.99)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C130(2.66)  LDD1510  [4]
 LDCM0270  AC15 HEK-293T C130(1.11)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C130(1.02)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C130(1.07)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C130(1.33)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C130(0.96)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C130(3.13)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C130(1.03)  LDD1520  [4]
 LDCM0283  AC23 HEK-293T C130(0.97)  LDD1522  [4]
 LDCM0285  AC25 HEK-293T C130(1.15)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C130(1.12)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C130(1.06)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C130(2.88)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C130(0.86)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C130(1.30)  LDD1529  [4]
 LDCM0292  AC31 HEK-293T C130(0.99)  LDD1531  [4]
 LDCM0294  AC33 HEK-293T C130(1.19)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C130(1.18)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C130(1.20)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C130(2.86)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C130(0.82)  LDD1537  [4]
 LDCM0300  AC39 HEK-293T C130(1.08)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C130(2.90)  LDD1540  [4]
 LDCM0303  AC41 HEK-293T C130(1.03)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C130(1.18)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C130(1.05)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C130(3.25)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C130(1.08)  LDD1546  [4]
 LDCM0309  AC47 HEK-293T C130(1.30)  LDD1548  [4]
 LDCM0311  AC49 HEK-293T C130(1.20)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C130(1.32)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C130(1.06)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C130(1.18)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C130(2.79)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C130(0.79)  LDD1555  [4]
 LDCM0318  AC55 HEK-293T C130(0.91)  LDD1557  [4]
 LDCM0320  AC57 HEK-293T C130(1.30)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C130(1.11)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C130(1.00)  LDD1561  [4]
 LDCM0324  AC60 HEK-293T C130(3.46)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C130(0.85)  LDD1564  [4]
 LDCM0327  AC63 HEK-293T C130(1.13)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C130(1.12)  LDD1568  [4]
 LDCM0248  AKOS034007472 HEK-293T C130(0.94)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C130(1.17)  LDD1570  [4]
 LDCM0369  CL100 HEK-293T C130(0.99)  LDD1573  [4]
 LDCM0371  CL102 HEK-293T C130(1.12)  LDD1575  [4]
 LDCM0373  CL104 HEK-293T C130(0.99)  LDD1577  [4]
 LDCM0375  CL106 HEK-293T C130(1.13)  LDD1579  [4]
 LDCM0377  CL108 HEK-293T C130(1.14)  LDD1581  [4]
 LDCM0379  CL11 HEK-293T C130(0.84)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C130(1.42)  LDD1584  [4]
 LDCM0382  CL112 HEK-293T C130(0.88)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C130(1.19)  LDD1588  [4]
 LDCM0386  CL116 HEK-293T C130(1.01)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C130(1.16)  LDD1592  [4]
 LDCM0391  CL120 HEK-293T C130(0.96)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C130(1.07)  LDD1597  [4]
 LDCM0395  CL124 HEK-293T C130(1.67)  LDD1599  [4]
 LDCM0397  CL126 HEK-293T C130(0.93)  LDD1601  [4]
 LDCM0399  CL128 HEK-293T C130(1.16)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C130(0.97)  LDD1605  [4]
 LDCM0403  CL16 HEK-293T C130(0.85)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C130(1.20)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C130(1.13)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C130(0.86)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C130(1.22)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C130(2.89)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C130(0.71)  LDD1613  [4]
 LDCM0411  CL23 HEK-293T C130(1.10)  LDD1615  [4]
 LDCM0414  CL26 HEK-293T C130(1.27)  LDD1618  [4]
 LDCM0416  CL28 HEK-293T C130(0.87)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C130(0.98)  LDD1621  [4]
 LDCM0419  CL30 HEK-293T C130(1.01)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C130(0.78)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C130(2.96)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C130(0.79)  LDD1626  [4]
 LDCM0424  CL35 HEK-293T C130(0.73)  LDD1628  [4]
 LDCM0429  CL4 HEK-293T C130(0.74)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C130(0.72)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C130(1.03)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C130(0.82)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C130(0.73)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C130(2.55)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C130(0.86)  LDD1639  [4]
 LDCM0437  CL47 HEK-293T C130(0.74)  LDD1641  [4]
 LDCM0440  CL5 HEK-293T C130(1.13)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C130(1.18)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C130(1.04)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C130(1.29)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C130(1.11)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C130(0.82)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C130(2.42)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C130(0.88)  LDD1651  [4]
 LDCM0450  CL59 HEK-293T C130(0.82)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C130(0.82)  LDD1654  [4]
 LDCM0454  CL62 HEK-293T C130(1.49)  LDD1657  [4]
 LDCM0456  CL64 HEK-293T C130(0.87)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C130(1.26)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C130(1.31)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C130(1.23)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C130(2.28)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C130(0.71)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C130(0.91)  LDD1665  [4]
 LDCM0464  CL71 HEK-293T C130(0.89)  LDD1667  [4]
 LDCM0467  CL74 HEK-293T C130(1.25)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C130(1.03)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C130(1.19)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C130(1.04)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C130(0.83)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C130(2.29)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C130(2.68)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C130(0.67)  LDD1678  [4]
 LDCM0477  CL83 HEK-293T C130(0.89)  LDD1680  [4]
 LDCM0480  CL86 HEK-293T C130(0.97)  LDD1683  [4]
 LDCM0482  CL88 HEK-293T C130(0.80)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C130(1.14)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C130(0.77)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C130(1.25)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C130(0.87)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C130(2.74)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C130(0.71)  LDD1691  [4]
 LDCM0490  CL95 HEK-293T C130(1.05)  LDD1693  [4]
 LDCM0493  CL98 HEK-293T C130(0.97)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C130(1.06)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C130(1.07)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C130(1.38)  LDD1497  [4]
 LDCM0024  KB05 SKMEL24 C130(1.39)  LDD3323  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
6-pyruvoyl tetrahydrobiopterin synthase (PTS) PTPS family Q03393
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Dynein light chain 1, cytoplasmic (DYNLL1) Dynein light chain family P63167
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Proteasome activator complex subunit 3 (PSME3) PA28 family P61289
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402