Details of the Target

General Information of Target

Target ID LDTP16182
Target Name Protein NYNRIN (NYNRIN)
Gene Name NYNRIN
Gene ID 57523
Synonyms
CGIN1; KIAA1305; Protein NYNRIN; NYN domain and retroviral integrase catalytic domain-containing protein; Protein cousin of GIN1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSTVSYWILNSTRNSIATLQGGRRLYSRYVSNRNKLKWRLFSRVPPTLNSSPCGGFTLC
KAYRHTSTEEDDFHLQLSPEQINEVLRAGETTHKILDLESRVPNSVLRFESNQLAANSPV
EDRRGVASCLQTNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQTLEHMEGAMESM
KPLLPILHWLKHPGDSIYKDVTSVHLDHLRVYWQELLDLHMEMGLSIEEALMYSFQRLDS
DISLEIQAPLEDEVTRNLSLQVAFSGATACMAHVDGIHLHVANAGDCRAILGVQEDNGMW
SCLPLTRDHNAWNQAELSRLKREHPESEDRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQ
RSILERGFNTEALNIYQFTPPHYYTPPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSN
EDVVRLVVGHLAEADWHKTDLAQRPANLGLMQSLLLQRKASGLHEADQNAATRLIRHAIG
NNEYGEMEAERLAAMLTLPEDLARMYRDDITVTVVYFNSESIGAYYKGG
Target Bioclass
Enzyme
Subcellular location
Membrane
Uniprot ID
Q9P2P1
Ensemble ID
ENST00000382554.4
HGNC ID
HGNC:20165

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.V534I .
COLO320 SNV: p.Q1499E DBIA    Probe Info 
DU145 Insertion: p.R152PfsTer7 .
EFO27 SNV: p.L1193I .
IGR1 SNV: p.G1314S .
IM95 Deletion: p.P1338LfsTer102 .
IPC298 SNV: p.P151L; p.Q1084Ter .
JURKAT SNV: p.Q498Ter; p.R1237Q .
KMS12BM SNV: p.D689Y .
KYSE30 SNV: p.D1264Y .
LN229 SNV: p.G1402E .
MCAS SNV: p.Y1064H .
MCC13 SNV: p.P837S .
MDAMB453 SNV: p.D435N .
MFE296 Insertion: p.V1339CfsTer63 .
MFE319 SNV: p.H215Q; p.M1101T; p.V1794M .
NCIH1155 SNV: p.S1043N .
NCIH1793 SNV: p.A1144S .
NCIH661 SNV: p.G511V .
OVISE SNV: p.S1412F .
RKO Deletion: p.G1452VfsTer16 DBIA    Probe Info 
RVH421 SNV: p.Y1428Ter .
SKMEL28 SNV: p.A1137D .
SW480 SNV: p.P114L .
TOV21G Deletion: p.P115LfsTer4
SNV: p.G934C;p.L964I		 .
WM793 Substitution: p.G439K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C73(2.04)  LDD3310  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C1874(1.14)  LDD1512  [3]
 LDCM0282  AC22 HEK-293T C1874(1.15)  LDD1521  [3]
 LDCM0284  AC24 HEK-293T C1874(1.61)  LDD1523  [3]
 LDCM0291  AC30 HEK-293T C1874(1.28)  LDD1530  [3]
 LDCM0293  AC32 HEK-293T C1874(1.54)  LDD1532  [3]
 LDCM0299  AC38 HEK-293T C1874(1.18)  LDD1538  [3]
 LDCM0302  AC40 HEK-293T C1874(1.44)  LDD1541  [3]
 LDCM0308  AC46 HEK-293T C1874(0.98)  LDD1547  [3]
 LDCM0310  AC48 HEK-293T C1874(1.42)  LDD1549  [3]
 LDCM0317  AC54 HEK-293T C1874(1.16)  LDD1556  [3]
 LDCM0319  AC56 HEK-293T C1874(1.05)  LDD1558  [3]
 LDCM0323  AC6 HEK-293T C1874(0.98)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C1874(1.10)  LDD1565  [3]
 LDCM0328  AC64 HEK-293T C1874(1.00)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C1874(1.27)  LDD1569  [3]
 LDCM0275  AKOS034007705 HEK-293T C1874(1.33)  LDD1514  [3]
 LDCM0368  CL10 HEK-293T C1874(0.98)  LDD1572  [3]
 LDCM0390  CL12 HEK-293T C1874(1.20)  LDD1594  [3]
 LDCM0410  CL22 HEK-293T C1874(1.32)  LDD1614  [3]
 LDCM0412  CL24 HEK-293T C1874(1.49)  LDD1616  [3]
 LDCM0423  CL34 HEK-293T C1874(0.99)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C1874(1.30)  LDD1629  [3]
 LDCM0436  CL46 HEK-293T C1874(1.42)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C1874(1.16)  LDD1642  [3]
 LDCM0449  CL58 HEK-293T C1874(1.04)  LDD1652  [3]
 LDCM0452  CL60 HEK-293T C1874(1.30)  LDD1655  [3]
 LDCM0463  CL70 HEK-293T C1874(1.01)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C1874(1.64)  LDD1668  [3]
 LDCM0476  CL82 HEK-293T C1874(0.93)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C1874(1.46)  LDD1681  [3]
 LDCM0489  CL94 HEK-293T C1874(0.93)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C1874(1.08)  LDD1694  [3]
 LDCM0022  KB02 697 C73(1.81)  LDD2245  [1]
 LDCM0023  KB03 697 C73(2.35)  LDD2662  [1]
 LDCM0024  KB05 COLO792 C73(2.04)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402