Details of the Target

General Information of Target

Target ID LDTP16171
Target Name Leucine-rich repeat and fibronectin type III domain-containing protein 1 (LRFN1)
Gene Name LRFN1
Gene ID 57622
Synonyms
KIAA1484; SALM2; Leucine-rich repeat and fibronectin type III domain-containing protein 1; Synaptic adhesion-like molecule 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MISSKMMSSNPEEDPLDTFLQYIEDMGMKAYDGLVIQNASDIARENDRLRNETNLAYLKE
KNEKRRRQEEAIKRIGGEVGRGHEGSYVGKHFRMGFMTMPAPQDRLPHPCSSGFSVRSQS
LHSVGGTDDDSSCGSRRQPPPKPKRDPSTKLSTSSETVSSTAASKSGKTPERTEASAKPR
PHSDEYSKKIPPPKPKRNPNTQLSTSFDETYIKKHGPRRTSLPRDSSLSQMGSPAGDPEE
EEPVYIEMVGNILRDFRKEDDDQSEAVYEEMKYPIFDDLGQDAKCDFDHHSCSSQCATPT
VPDLDFAKASVPCPPKGLLCDIPPPFPNLLSHRPPLLVFPPAPVHCSPNSDESPLTPLEV
TKLPVLENVSYMKQPAGASPSTLPSHVPGHAKLEKEQAAALGPASATPALSSSPPPPSTL
YRTQSPHGYPKSHSTSPSPVSMGRSLTPLSLKRPPPYDAVHSGSLSRSSPSVPHSTPRPV
SQDGAKMVNAAVNTYGAAPGGSRSRTPTSPLEELTSLFSSGRSLLRKSSSGRRSKEPAEK
STEELKVRSHSTEPLPKLDNKERGHHGASSSREPVKAQEWDGTPGTPVVTSRLGRCSVSP
TLLAGNHSSEPKVSCKLGRSASTSGVPPPSVTPLRQSSDLQQSQVPSSLANRD
Target Bioclass
Immunoglobulin
Family
LRFN family
Subcellular location
Membrane
Function
Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1.
Uniprot ID
Q9P244
Ensemble ID
ENST00000248668.5
HGNC ID
HGNC:29290

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C583(0.91)  LDD1511  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C651(1.16)  LDD1513  [1]
 LDCM0281  AC21 HEK-293T C583(0.87)  LDD1520  [1]
 LDCM0283  AC23 HEK-293T C651(0.97)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C651(0.99)  LDD1523  [1]
 LDCM0289  AC29 HEK-293T C583(0.91)  LDD1528  [1]
 LDCM0292  AC31 HEK-293T C651(1.12)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C651(0.96)  LDD1532  [1]
 LDCM0298  AC37 HEK-293T C583(0.94)  LDD1537  [1]
 LDCM0300  AC39 HEK-293T C651(1.19)  LDD1539  [1]
 LDCM0302  AC40 HEK-293T C651(0.96)  LDD1541  [1]
 LDCM0307  AC45 HEK-293T C583(0.96)  LDD1546  [1]
 LDCM0309  AC47 HEK-293T C651(1.16)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C651(1.08)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C583(0.80)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C583(0.93)  LDD1555  [1]
 LDCM0318  AC55 HEK-293T C651(1.18)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C651(0.93)  LDD1558  [1]
 LDCM0325  AC61 HEK-293T C583(1.01)  LDD1564  [1]
 LDCM0327  AC63 HEK-293T C651(1.11)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C651(1.14)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C651(1.02)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C651(0.98)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C583(0.91)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C651(1.01)  LDD1514  [1]
 LDCM0379  CL11 HEK-293T C651(0.93)  LDD1583  [1]
 LDCM0390  CL12 HEK-293T C651(1.22)  LDD1594  [1]
 LDCM0409  CL21 HEK-293T C583(0.94)  LDD1613  [1]
 LDCM0411  CL23 HEK-293T C651(1.30)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C651(1.48)  LDD1616  [1]
 LDCM0422  CL33 HEK-293T C583(0.86)  LDD1626  [1]
 LDCM0424  CL35 HEK-293T C651(1.21)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C651(1.02)  LDD1629  [1]
 LDCM0435  CL45 HEK-293T C583(0.86)  LDD1639  [1]
 LDCM0437  CL47 HEK-293T C651(1.38)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C651(1.22)  LDD1642  [1]
 LDCM0448  CL57 HEK-293T C583(1.05)  LDD1651  [1]
 LDCM0450  CL59 HEK-293T C651(1.27)  LDD1653  [1]
 LDCM0452  CL60 HEK-293T C651(1.35)  LDD1655  [1]
 LDCM0461  CL69 HEK-293T C583(0.91)  LDD1664  [1]
 LDCM0464  CL71 HEK-293T C651(1.24)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C651(1.15)  LDD1668  [1]
 LDCM0475  CL81 HEK-293T C583(0.89)  LDD1678  [1]
 LDCM0477  CL83 HEK-293T C651(1.20)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C651(1.17)  LDD1681  [1]
 LDCM0484  CL9 HEK-293T C583(1.07)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C583(0.82)  LDD1691  [1]
 LDCM0490  CL95 HEK-293T C651(1.39)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C651(1.17)  LDD1694  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402