Details of the Target

General Information of Target

Target ID LDTP16106
Target Name Zinc finger protein 701 (ZNF701)
Gene Name ZNF701
Gene ID 55762
Synonyms
Zinc finger protein 701
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPSADTWDLFSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGKNLQEKSVPKAAQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS
LKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVHELVDLIPEYEIACEHEHSNCLLIAHRKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH
QRKNKSKAISGC
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9NV72
Ensemble ID
ENST00000301093.6
HGNC ID
HGNC:25597

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C427(0.83)  LDD0602  [1]
IPM
 Probe Info  		N.A.  LDD0005  [2]
HHS-465
 Probe Info  		K362(0.00); K365(0.00); K502(0.00); K505(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0285  AC25 HCT 116 C427(0.83)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C427(1.20)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C427(1.17)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C427(0.95)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C427(1.75)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C427(1.47)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C427(0.92)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C427(1.27)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C427(0.84)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C427(0.88)  LDD0612  [1]
 LDCM0367  CL1 HCT 116 C427(1.16)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C427(0.79)  LDD0685  [1]
 LDCM0379  CL11 HCT 116 C427(0.75)  LDD0696  [1]
 LDCM0382  CL112 HCT 116 C427(1.11)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C427(1.02)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C427(1.23)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C427(0.96)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C427(0.88)  LDD0703  [1]
 LDCM0390  CL12 HCT 116 C427(0.79)  LDD0707  [1]
 LDCM0400  CL13 HCT 116 C427(0.97)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C427(0.97)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C427(0.76)  LDD0719  [1]
 LDCM0407  CL2 HCT 116 C427(0.75)  LDD0724  [1]
 LDCM0418  CL3 HCT 116 C427(0.87)  LDD0735  [1]
 LDCM0429  CL4 HCT 116 C427(0.90)  LDD0746  [1]
 LDCM0436  CL46 HCT 116 C427(0.98)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C427(0.98)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C427(0.90)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C427(0.77)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C427(0.90)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C427(0.73)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C427(1.01)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C427(1.13)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C427(1.28)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C427(0.84)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C427(0.87)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C427(0.86)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C427(0.88)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C427(0.93)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C427(0.92)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C427(0.96)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C427(0.94)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C427(0.92)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C427(0.89)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C427(0.94)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C427(1.00)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C427(1.02)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C427(0.90)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C427(0.96)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C427(1.10)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C427(0.96)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C427(0.79)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C427(0.81)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C427(1.07)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C427(1.05)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C427(1.02)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C427(1.04)  LDD0784  [1]
 LDCM0473  CL8 HCT 116 C427(0.81)  LDD0790  [1]
 LDCM0484  CL9 HCT 116 C427(1.04)  LDD0801  [1]
 LDCM0468  Fragment33 HCT 116 C427(1.06)  LDD0785  [1]
 LDCM0022  KB02 A375.S2 C493(1.28)  LDD2256  [4]
 LDCM0023  KB03 A2780 C493(1.53)  LDD2671  [4]
 LDCM0024  KB05 NCI-H3122 C493(3.48)  LDD3360  [4]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840