Details of the Target

General Information of Target

Target ID LDTP15980
Target Name Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1)
Gene Name CRISPLD1
Gene ID 83690
Synonyms
CRISP10; LCRISP1; Cysteine-rich secretory protein LCCL domain-containing 1; CocoaCrisp; Cysteine-rich secretory protein 10; CRISP-10; LCCL domain-containing cysteine-rich secretory protein 1; Trypsin inhibitor Hl
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADGGGPKDAPSLRSSPGPAPRVPRAVGPSGGGGETPRTAALALRFDKPIKQAFYNTGAV
LFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLTRLGRHWLQRLHRAHTPIV
LAALLLPLCFVDYGVEALGEQALRRRRLLLLLGAGGPLLYGLYCLGSYLGVQVLLVHAAT
LICRGLDYFSSLWIWTLVVGYVLTVSFKWNASTERYLRAVSIPVWIILLFHLASLAGSWR
IPVFLVIVFLMSVGTLYEKQNGKESSGAELPGQVISMAASTLANLAISITGYESSSEDQP
STQPAEAVDRGESAPTLSTSPSPSSPSPTSPSPTLGRRRPEIGTFLRKKKTSDIYFVSLV
WAIVVMQIWLNLWIVQLLPVPIAVWILKKLVIHFGVVDFLEKRYHVWWGIIESFLKERQG
ALAPWPIVGLGKFLLKVDSKLWHWLNKKMIIWLEKMLDKIISIFIIFLLVIGTLLLALLL
TAKVHQESVHMIEVTSNLINETLANHPEWANWLPEAQVVQRALNSAANNVYQYGREWITH
KLHKILGDKVNNTAVIEKQVLELWDRLYHSWFVKNVTHSGRHKGQKLHVSRQNSWLGDIL
DWQDIVSFVHENIETFLSILESLWIVMSRNVSLLFTTVTTLLTILFYSGTALLNFVLSLI
IFLTTLFYLLSSSDEYYKPVKWVISLTPLSQPGPSSNIIGQSVEEAIRGVFDASLKMAGF
YGLYTWLTHTMFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLDLWLTQGLGCKAILLL
IFHLLPTYFVDTAIYSDISGGGHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIY
SAMLVSPTNSVPTPNQTPWPAQPQRTFRDISEDLKSSVG
Target Bioclass
Other
Family
CRISP family
Subcellular location
Secreted
Uniprot ID
Q9H336
Ensemble ID
ENST00000262207.9
HGNC ID
HGNC:18206

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.N211K .
HCT116 SNV: p.M40V .
HCT15 SNV: p.G490E .
HEC1 SNV: p.P229L .
HEC1B SNV: p.P229L .
MCC26 Substitution: p.G305K .
MDAMB231 SNV: p.S64R .
NCIH446 SNV: p.A122E .
PEO1 SNV: p.P488S .
SG231 SNV: p.G108R .
SNU1079 SNV: p.C235F .
SW756 SNV: p.A199T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		4.37  LDD0318  [1]
OPA-S-S-alkyne
 Probe Info  		K468(1.33); K304(2.33); K242(2.36)  LDD3494  [2]
DBIA
 Probe Info  		C413(1.00)  LDD1508  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C413(1.00)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C413(1.12); C313(0.93)  LDD1509  [3]
 LDCM0259  AC14 HEK-293T C313(0.98)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C413(1.01)  LDD1513  [3]
 LDCM0277  AC18 HEK-293T C413(1.02)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C413(1.52); C313(1.00)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C413(0.99)  LDD1518  [3]
 LDCM0281  AC21 HEK-293T C413(1.03)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C313(1.02)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C413(0.94)  LDD1522  [3]
 LDCM0286  AC26 HEK-293T C413(0.93)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C413(1.07); C313(0.96)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C413(1.13)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C413(1.19); C313(0.93)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C313(0.94)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C413(1.01)  LDD1531  [3]
 LDCM0295  AC34 HEK-293T C413(0.98)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C413(1.19); C313(1.02)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C413(1.03)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C313(1.00)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C413(1.02)  LDD1539  [3]
 LDCM0304  AC42 HEK-293T C413(1.20)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C413(1.11); C313(0.95)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C413(1.06)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C313(0.94)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C413(1.05)  LDD1548  [3]
 LDCM0312  AC5 HEK-293T C413(1.00)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C413(1.06)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C413(1.18); C313(0.94)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C413(1.07)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C313(1.03)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C413(1.02)  LDD1557  [3]
 LDCM0321  AC58 HEK-293T C413(0.97)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C413(1.01); C313(0.91)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C313(1.01)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C413(1.06)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C313(0.98)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C413(0.96)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C413(1.10)  LDD1568  [3]
 LDCM0248  AKOS034007472 HEK-293T C413(1.07)  LDD1511  [3]
 LDCM0367  CL1 HEK-293T C413(1.18)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C313(1.49)  LDD1572  [3]
 LDCM0370  CL101 HEK-293T C413(1.05)  LDD1574  [3]
 LDCM0374  CL105 HEK-293T C413(1.03)  LDD1578  [3]
 LDCM0378  CL109 HEK-293T C413(1.07)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C413(1.27)  LDD1583  [3]
 LDCM0383  CL113 HEK-293T C413(1.15)  LDD1587  [3]
 LDCM0387  CL117 HEK-293T C413(1.02)  LDD1591  [3]
 LDCM0392  CL121 HEK-293T C413(1.10)  LDD1596  [3]
 LDCM0396  CL125 HEK-293T C413(1.17)  LDD1600  [3]
 LDCM0400  CL13 HEK-293T C413(1.18)  LDD1604  [3]
 LDCM0405  CL18 HEK-293T C413(1.00)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C413(1.20); C313(1.00)  LDD1610  [3]
 LDCM0409  CL21 HEK-293T C413(1.31)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C313(1.58)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C413(1.33)  LDD1615  [3]
 LDCM0413  CL25 HEK-293T C413(0.91)  LDD1617  [3]
 LDCM0419  CL30 HEK-293T C413(1.01)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C413(1.14); C313(0.90)  LDD1624  [3]
 LDCM0422  CL33 HEK-293T C413(1.22)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C313(1.19)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C413(1.26)  LDD1628  [3]
 LDCM0426  CL37 HEK-293T C413(1.07)  LDD1630  [3]
 LDCM0432  CL42 HEK-293T C413(0.85)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C413(1.17); C313(1.01)  LDD1637  [3]
 LDCM0435  CL45 HEK-293T C413(1.24)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C313(1.40)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C413(1.27)  LDD1641  [3]
 LDCM0439  CL49 HEK-293T C413(0.99)  LDD1643  [3]
 LDCM0445  CL54 HEK-293T C413(1.02)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C413(1.12); C313(1.01)  LDD1649  [3]
 LDCM0448  CL57 HEK-293T C413(1.22)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C313(1.59)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C413(1.13)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C413(0.95)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C413(1.03)  LDD1656  [3]
 LDCM0458  CL66 HEK-293T C413(1.07)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C413(1.22); C313(0.98)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C413(0.93)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C413(1.19); C313(1.02)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C313(1.32)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C413(1.15)  LDD1667  [3]
 LDCM0466  CL73 HEK-293T C413(0.98)  LDD1669  [3]
 LDCM0471  CL78 HEK-293T C413(0.88)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C413(1.16); C313(1.00)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C413(1.16)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C313(1.29)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C413(1.13)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C413(1.24)  LDD1682  [3]
 LDCM0484  CL9 HEK-293T C413(1.05)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C413(0.93)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C413(1.21); C313(1.00)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C413(1.15)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C313(1.15)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C413(1.33)  LDD1693  [3]
 LDCM0492  CL97 HEK-293T C413(1.04)  LDD1695  [3]
 LDCM0022  KB02 MGG123 C422(2.28)  LDD2469  [4]
 LDCM0023  KB03 MGG123 C422(2.38)  LDD2886  [4]
 LDCM0024  KB05 MGG123 C422(2.19)  LDD3303  [4]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840