Details of the Target

General Information of Target

Target ID LDTP15907
Target Name Hemogen (HEMGN)
Gene Name HEMGN
Gene ID 55363
Synonyms
EDAG; NDR; Hemogen; Erythroid differentiation-associated gene protein; EDAG-1; Hemopoietic gene protein; Negative differentiation regulator protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAAVACVDYFAADVLMAISSGAVVHRGRPGPEGAGPAAGLDVRAARREAASPGTPGPPP
PPPAASGPGPGAAAAPHLLAASILADLRGGPGAAPGGASPASSSSAASSPSSGRAPGAAP
SAAAKSHRCPFPDCAKAYYKSSHLKSHLRTHTGERPFACDWQGCDKKFARSDELARHHRT
HTGEKRFSCPLCSKRFTRSDHLAKHARRHPGFHPDLLRRPGARSTSPSDSLPCSLAGSPA
PSPAPSPAPAGL
Target Bioclass
Other
Subcellular location
Nucleus
Function
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
Uniprot ID
Q9BXL5
Ensemble ID
ENST00000259456.7
HGNC ID
HGNC:17509

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		4.94  LDD0215  [1]
IA-alkyne
 Probe Info  		C244(1.27); C256(1.27)  LDD0304  [2]
DBIA
 Probe Info  		C233(2.54)  LDD3408  [3]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		11.52  LDD0476  [4]
FFF probe3
 Probe Info  		20.00  LDD0465  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 EoL-1 C422(1.22); C205(1.34); C329(0.96)  LDD2324  [3]
 LDCM0023  KB03 A3-KAW C233(1.40)  LDD2674  [3]
 LDCM0024  KB05 RL C233(2.54)  LDD3408  [3]
 LDCM0131  RA190 MM1.R C244(1.27); C256(1.27)  LDD0304  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-terminal-binding protein 1 (CTBP1) D-isomer specific 2-hydroxyacid dehydrogenase family Q13363
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleophosmin (NPM1) Nucleoplasmin family P06748

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.