Details of the Target

General Information of Target

Target ID LDTP15810
Target Name Kelch-like protein 5 (KLHL5)
Gene Name KLHL5
Gene ID 51088
Synonyms
Kelch-like protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVTKAFVLLAIFAEASAKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCY
NGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFS
CTYHSTYLVNQAAFDQRVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFVLEASEI
GSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGRDH
RATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQTGGVLVVELS
LRSRGFSSLYSFSDVLHHLIMMLGICAVL
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton
Uniprot ID
Q96PQ7
Ensemble ID
ENST00000261425.7
HGNC ID
HGNC:6356

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C677(2.74)  LDD3314  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C677(1.07); C434(1.21)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C677(0.93)  LDD1513  [2]
 LDCM0282  AC22 HEK-293T C677(0.86); C434(0.95)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C677(1.11)  LDD1522  [2]
 LDCM0291  AC30 HEK-293T C677(1.04); C434(1.11)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C677(1.07)  LDD1531  [2]
 LDCM0299  AC38 HEK-293T C677(0.92); C434(0.95)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C677(1.06)  LDD1539  [2]
 LDCM0308  AC46 HEK-293T C677(0.91); C434(0.99)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C677(1.02)  LDD1548  [2]
 LDCM0317  AC54 HEK-293T C677(0.93); C434(1.14)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C677(0.99)  LDD1557  [2]
 LDCM0323  AC6 HEK-293T C677(1.10); C434(1.31)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C677(1.05); C434(1.24)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C677(1.15)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C677(1.13)  LDD1568  [2]
 LDCM0368  CL10 HEK-293T C677(0.84); C434(1.10)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C677(1.11)  LDD1573  [2]
 LDCM0372  CL103 HEK-293T C677(0.96)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C677(0.98)  LDD1577  [2]
 LDCM0376  CL107 HEK-293T C677(0.82)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C677(0.87)  LDD1581  [2]
 LDCM0379  CL11 HEK-293T C677(0.89)  LDD1583  [2]
 LDCM0381  CL111 HEK-293T C677(0.86)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C677(0.82)  LDD1586  [2]
 LDCM0385  CL115 HEK-293T C677(0.91)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C677(0.85)  LDD1590  [2]
 LDCM0389  CL119 HEK-293T C677(0.93)  LDD1593  [2]
 LDCM0391  CL120 HEK-293T C677(0.92)  LDD1595  [2]
 LDCM0394  CL123 HEK-293T C677(0.69)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C677(0.92)  LDD1599  [2]
 LDCM0398  CL127 HEK-293T C677(0.83)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C677(1.12)  LDD1603  [2]
 LDCM0402  CL15 HEK-293T C677(0.82)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C677(0.89)  LDD1607  [2]
 LDCM0410  CL22 HEK-293T C677(1.25); C434(0.82)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C677(1.01)  LDD1615  [2]
 LDCM0415  CL27 HEK-293T C677(0.87)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C677(0.75)  LDD1620  [2]
 LDCM0418  CL3 HEK-293T C677(0.85)  LDD1622  [2]
 LDCM0423  CL34 HEK-293T C677(1.20); C434(0.94)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C677(1.04)  LDD1628  [2]
 LDCM0428  CL39 HEK-293T C677(0.75)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C677(0.80)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C677(0.89)  LDD1634  [2]
 LDCM0436  CL46 HEK-293T C677(0.95); C434(1.19)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C677(0.88)  LDD1641  [2]
 LDCM0443  CL52 HEK-293T C677(0.84)  LDD1646  [2]
 LDCM0449  CL58 HEK-293T C677(0.99); C434(0.87)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C677(1.17)  LDD1653  [2]
 LDCM0455  CL63 HEK-293T C677(0.94)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C677(0.83)  LDD1659  [2]
 LDCM0463  CL70 HEK-293T C677(1.15); C434(1.09)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C677(1.04)  LDD1667  [2]
 LDCM0469  CL76 HEK-293T C677(0.94)  LDD1672  [2]
 LDCM0476  CL82 HEK-293T C677(1.05); C434(0.79)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C677(1.03)  LDD1680  [2]
 LDCM0481  CL87 HEK-293T C677(1.11)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C677(1.07)  LDD1685  [2]
 LDCM0489  CL94 HEK-293T C677(0.99); C434(1.21)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C677(1.02)  LDD1693  [2]
 LDCM0494  CL99 HEK-293T C677(0.84)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C677(0.86)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C677(0.93)  LDD1671  [2]
 LDCM0022  KB02 769-P C677(1.58)  LDD2246  [1]
 LDCM0023  KB03 42-MG-BA C677(2.32)  LDD2661  [1]
 LDCM0024  KB05 IGR37 C677(2.74)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402