Details of the Target

General Information of Target

Target ID LDTP15805
Target Name Rho guanine nucleotide exchange factor 17 (ARHGEF17)
Gene Name ARHGEF17
Gene ID 9828
Synonyms
KIAA0337; TEM4; Rho guanine nucleotide exchange factor 17; 164 kDa Rho-specific guanine-nucleotide exchange factor; p164-RhoGEF; p164RhoGEF; Tumor endothelial marker 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNLVDLWLTRSLSMCLLLQSFVLMILCFHSASMCPKGCLCSSSGGLNVTCSNANLKEIPR
DLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDL
SDNRIQSVHKNAFNNLKARARIANNPWHCDCTLQQVLRSMASNHETAHNVICKTSVLDEH
AGRPFLNAANDADLCNLPKKTTDYAMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLK
SLPSRQKKADEPDDISTVV
Target Bioclass
Other
Function Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases.
Uniprot ID
Q96PE2
Ensemble ID
ENST00000263674.4
HGNC ID
HGNC:21726

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1134(3.08); C1479(6.17)  LDD3310  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
NAIA_5
 Probe Info  		C231(0.00); C1563(0.00)  LDD2224  [2]
IPM
 Probe Info  		C176(0.00); C549(0.00); C1563(0.00)  LDD0147  [3]
TFBX
 Probe Info  		C176(0.00); C1479(0.00)  LDD0148  [3]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C1479(0.89)  LDD1523  [5]
 LDCM0293  AC32 HEK-293T C1479(0.97)  LDD1532  [5]
 LDCM0302  AC40 HEK-293T C1479(0.95)  LDD1541  [5]
 LDCM0310  AC48 HEK-293T C1479(0.98)  LDD1549  [5]
 LDCM0319  AC56 HEK-293T C1479(0.96)  LDD1558  [5]
 LDCM0328  AC64 HEK-293T C1479(0.92)  LDD1567  [5]
 LDCM0345  AC8 HEK-293T C1479(1.00)  LDD1569  [5]
 LDCM0275  AKOS034007705 HEK-293T C1479(0.98)  LDD1514  [5]
 LDCM0369  CL100 HEK-293T C1479(1.02)  LDD1573  [5]
 LDCM0373  CL104 HEK-293T C1479(1.04)  LDD1577  [5]
 LDCM0377  CL108 HEK-293T C1479(1.03)  LDD1581  [5]
 LDCM0382  CL112 HEK-293T C1479(1.05)  LDD1586  [5]
 LDCM0386  CL116 HEK-293T C1479(1.06)  LDD1590  [5]
 LDCM0390  CL12 HEK-293T C1479(0.88)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C1479(1.04)  LDD1595  [5]
 LDCM0395  CL124 HEK-293T C1479(1.08)  LDD1599  [5]
 LDCM0399  CL128 HEK-293T C1479(1.03)  LDD1603  [5]
 LDCM0403  CL16 HEK-293T C1479(1.07)  LDD1607  [5]
 LDCM0412  CL24 HEK-293T C1479(0.93)  LDD1616  [5]
 LDCM0416  CL28 HEK-293T C1479(0.94)  LDD1620  [5]
 LDCM0425  CL36 HEK-293T C1479(0.93)  LDD1629  [5]
 LDCM0429  CL4 HEK-293T C1479(0.94)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C1479(1.11)  LDD1634  [5]
 LDCM0438  CL48 HEK-293T C1479(1.01)  LDD1642  [5]
 LDCM0443  CL52 HEK-293T C1479(1.10)  LDD1646  [5]
 LDCM0452  CL60 HEK-293T C1479(1.09)  LDD1655  [5]
 LDCM0456  CL64 HEK-293T C1479(1.06)  LDD1659  [5]
 LDCM0465  CL72 HEK-293T C1479(1.08)  LDD1668  [5]
 LDCM0469  CL76 HEK-293T C1479(1.10)  LDD1672  [5]
 LDCM0478  CL84 HEK-293T C1479(0.89)  LDD1681  [5]
 LDCM0482  CL88 HEK-293T C1479(1.12)  LDD1685  [5]
 LDCM0491  CL96 HEK-293T C1479(0.84)  LDD1694  [5]
 LDCM0022  KB02 769-P C231(1.49); C1479(2.24)  LDD2246  [1]
 LDCM0023  KB03 769-P C231(1.74); C1479(3.12)  LDD2663  [1]
 LDCM0024  KB05 COLO792 C1134(3.08); C1479(6.17)  LDD3310  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402